Theodoros Tsetsenis, Ph.D.
Research Assistant Professor of Neuroscience
Senior Research Investigator, University of Pennsylvania
Department: Neuroscience
Contact information
Department of Neuroscience
415 Curie Blvd,
Clinical Research Building, Room 202A
Philadelphia, PA
415 Curie Blvd,
Clinical Research Building, Room 202A
Philadelphia, PA
Email:
theot@pennmedicine.upenn.edu
theot@pennmedicine.upenn.edu
Education:
B.Sc. (Biology)
University of Patras, 1999.
M.Sc. (Industrial Pharmacy)
University of Patras, 2001.
Ph.D. (Molecular Biology/Neuroscience)
EMBL/University of Heidelberg, 2007.
Permanent linkB.Sc. (Biology)
University of Patras, 1999.
M.Sc. (Industrial Pharmacy)
University of Patras, 2001.
Ph.D. (Molecular Biology/Neuroscience)
EMBL/University of Heidelberg, 2007.
Description of Research Expertise
Behavioral NeuroscienceFluorescence Microscopy
Confocal Microscopy
Immunohistochemistry
Optogenetics
In vivo Pharmacology
Stereotactic Surgery
Viral Tracing
Fear Conditioning
Cell Culture
Genetics
Molecular Cloning
Western Blotting
Selected Publications
Tsetsenis T, Badyna JK, Li R, Dani JA.: Activation of a Locus Coeruleus to Dorsal Hippocampus Noradrenergic Circuit Facilitates Associative Learning. Front Cell Neurosci 16: 887679, Apr 2022.Tsetsenis T, Badyna JK, Wilson JA, Zhang X, Krizman EN, Subramaniyan M, Yang K, Thomas SA, Dani JA.: Midbrain dopaminergic innervation of the hippocampus is sufficient to modulate formation of aversive memories. Proc Natl Acad Sci U S A 118: e2111069118, Oct 2021.
Subramaniyan M, Manivannan S, Chelur V, Tsetsenis T, Jiang E, Dani JA.: Fear conditioning potentiates the hippocampal CA1 commissural pathway in vivo and increases awake phase sleep. Hippocampus 2021.
Trotter JH, Hao J, Maxeiner S, Tsetsenis T, Liu Z, Zhuang X, Südhof TC.: Synaptic neurexin-1 assembles into dynamically regulated active zone nanoclusters. J Cell Biol 218: 2677-2698, Aug 2019.
Anderson GR, Maxeiner S, Sando R, Tsetsenis T, Malenka RC, Südhof TC.: Postsynaptic adhesion GPCR latrophilin-2 mediates target recognition in entorhinal-hippocampal synapse assembly. J Cell Biol 216: 3831-3846, Nov 2017.
Tsetsenis T.: Monitoring Synapses Via Trans-Synaptic GFP Complementation. Methods Mol Biol 2017.
Madroñal N, Delgado-García JM, Fernández-Guizán A, Chatterjee J, Köhn M, Mattucci C, Jain A, Tsetsenis T, Illarionova A, Grinevich V, Gross CT, Gruart A.: Rapid erasure of hippocampal memory following inhibition of dentate gyrus granule cells. Nat Commun 7: 10923, Mar 2016.
Broussard JI, Yang K, Levine AT, Tsetsenis T, Jenson D, Cao F, Garcia I, Arenkiel BR, Zhou FM, De Biasi M, Dani JA.: Dopamine Regulates Aversive Contextual Learning and Associated In Vivo Synaptic Plasticity in the Hippocampus. Cell Rep 14: 1930-9, Mar 2016.
Samuels BA, Anacker C, Hu A, Levinstein MR, Pickenhagen A, Tsetsenis T, Madroñal N, Donaldson ZR, Drew LJ, Dranovsky A, Gross CT, Tanaka KF, Hen R.: 5-HT1A receptors on mature dentate gyrus granule cells are critical for the antidepressant response. Nat Neurosci 2015.
Tsetsenis T, Boucard AA, Araç D, Brunger AT, Südhof TC.: Direct visualization of trans-synaptic neurexin-neuroligin interactions during synapse formation. J Neurosci 34: 15083-96, Nov 2014.