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Alexander C. Wright, Ph.D.

Alexander C. Wright, Ph.D.

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Adjunct Associate Professor of Radiology
Department: Radiology

Contact information
Radiology, 1 Silverstein
3400 Spruce Street
Philadelphia, PA 19104
Education:
B.S. (Physics)
Georgia Institute of Technology, 1986.
Ph.D. (Physics)
Georgia Institute of Technology, 1991.
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Description of Research Expertise

Dr. Wright’s research involves the development of micro-MRI and micro-CT hardware, acquisition strategies and quantitative methods for the purpose of imaging the microstructure of biological tissues at cellular resolution. This includes the design and construction of novel and optimized radio-frequency and gradient coils for micro-MRI, and the development of quantitative image acquisition and analysis techniques for the characterization of tissue micro-architecture using both micro-MRI and micro-CT. Current focus is on developing micro-MRI methods for imaging the intervertebral disc ex vivo in order to measure collagen fiber architecture in the annulus fibrosus of the disc. In addition, micro-CT techniques are being developed for imaging and characterizing structural phenotypes in both soft-tissue and calcified specimens at extremely high resolution (1-10 µm isotropic). Another research effort involves the design, construction and implementation of transmit-receive RF coils for in vivo MRI of bone in the human tibia, using a whole-body 7 Tesla MRI scanner.

Selected Publications

J. F. DeLucca, J. M. Peloquin, L. J. Smith, A. C. Wright, E. J. Vresilovic, D. M. Elliott: MRI quantification of human spine cartilage endplate geometry: Comparison with age, degeneration, level, and disc geometry. Journal of Orthopaedic Research May 2016 Notes: May 27. doi: 10.1002/jor.23315. [Epub ahead of print]

Z. Zhou, A. T. Tang, W. Y. Wong, S. Bamezai, L. M. Goddard, R. Shenkar, S. Zhou, J. Yang, A. C. Wright, M. Foley, J. S. Arthur, K. J. Whitehead, I. A. Awad, D. Y. Li, X. Zheng, M. L. Kahn: Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling. Nature 532(7597): 122-126, April 2016 Notes: Mar 30. doi: 10.1038/nature17178. [Epub ahead of print]

A. C. Wright, J. H. Yoder, E. J. Vresilovic, D. M. Elliott: Theory of MRI contrast in the annulus fibrosus of the intervertebral disc. Magnetic Resonance Materials in Physics, Biology, and Medicine January 2016 Notes: MAGMA. 2016 Jan 11. [Epub ahead of print]

B. L. Showalter, J. F. DeLucca, J. M. Peloquin, D. H. Cortes, J. H. Yoder, N. T. Jacobs, A. C. Wright, J. C. Gee, E. J. Vresilovic, D. M. Elliott: A novel human intervertebral disc strain template to quantify regional three-dimensional strains in a population and compare to internal strains predicted by a finite element model. Journal of Orthopaedic Research December 2015 Notes: doi: 10.1002/jor.23137. [Epub ahead of print]

C. S. Rajapakse, M. Bashoor-Zadeh, C. Li, W. Sun, A. C. Wright, F. W. Wehrli: Volumetric cortical bone porosity assessment with MR imaging: validation and clinical feasibility. Radiology 276(2): 526-535, August 2015.

J. E. McDonough, L. Knudsen, A. C. Wright, W. M. Elliott, M. Ochs, J. C. Hogg: Regional differences in alveolar density in the human lung are related to lung height. Journal of Applied Physiology (1985) 118(11): 1429-1434, June 2015.

J. Huang, T. Wang, A. C. Wright, J. Yang, S. Zhou, L. Li, J. Yang, A. Small, M. S. Parmacek: Myocardin is required for maintenance of vascular and visceral smooth muscle homeostasis during postnatal development. Proceedings of the National Academy of Sciences, USA 112(14): 4447-4452, April 2015.

J. H. Yoder, J. M. Peloquin, G. Song, N. J. Tustison, S. M. Moon, A. C. Wright, E. J. Vresilovic, J. C. Gee, D. M. Elliott: Internal three-dimensional strains in human intervertebral discs under axial compression quantified noninvasively by magnetic resonance imaging and image registration. Journal of Biomechanical Engineering 136(11): 111008 (9 pages), November 2014.

D. H. Cortes, J. F. Magland, A. C. Wright, D. M. Elliott: The shear modulus of the nucleus pulposus measured using magnetic resonance elastography: A potential biomarker for intervertebral disc degeneration. Magnetic Resonance in Medicine 72(1): 211-219, July 2014.

A. C. Seifert, C. Li, C. S. Rajapakse, M. Bashoor-Zadeh, Y. A. Bhagat, A. C. Wright, B. S. Zemel, A. Zavaliangos, F. W. Wehrli: Bone mineral (31)P and matrix-bound water densities measured by solid-state (31)P and (1)H MRI. NMR in Biomedicine 27(7): 739-748, July 2014.

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Last updated: 06/15/2016
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