Jason N. Rosenbaum, MD

faculty photo
Assistant Professor of Clinical Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine

Contact information
3020 Market Street, Suite 220
Philadelphia, PA 19128
Office: 267-586-2525
Fax: 215-898-9817
Lab: 215-349-8456
BA (Molecular and Cell Biology/Integrative Biology)
University of California at Berkley, 1998.
MD (Medicine)
Northwestern University Feinberg School of Medicine, 2011.
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Description of Clinical Expertise

Molecular Diagnostics
Massively Parallel (Next-Generation) Sequencing
Molecular Biomarkers
Genomic Alterations in Lung Cancer
Neuroendocrine Neoplasms
Clinical Test Development and Validation

Selected Publications

J.N. Rosenbaum, R. Bloom, J.T. Forys, J. Hiken, J.R. Armstrong, J. Branson, S. McNulty, P.D. Velu, K. Pepin, H. Abel, C.E. Cotrell, J.D. Pfeifer, S. Kulkarni, R. Govindan, E.Q. Konnick, C.M. Lockwood, E.J. Duncavage: Genomic Heterogeneity of ALK Fusion Breakpoints in Non-Small Cell Lung Cancer. Modern Pathology. Nature, 31(5): 791-808, May 2018.

J.N. Rosenbaum, D. Aisner: Keeping It Personal: CMS-Proposed Coverage Restrictions for NGS Challenge Innovation in Personalized Care. IASLC Lung Cancer News 3(2): 9, April 2018.

P.S. Rush, J.N. Rosenbaum, R.M. Baus, D.D. Bennett, R.V. Lloyd. (2017): INSM1: A Novel Nuclear Marker in Merkel Cell Carcinoma (Cutaneous Neuroendocrine Carcinoma). Journal of Cutaneous Pathology 45(2): 129-135, February 2018.

S.F. Priore, J.N. Rosenbaum, J.J. Roth: AMP Case Report: Diagnostic Pitfalls of Testing Rare Molecular Aberrations in Lung Adenocarcinomas. CAP Today 2018.

R. Sussman, S.Shaffer, E. Azzato, D. DeSloover, M. Farooqi, A. Meyer, D. Lieberman, A. Bigdeli, C. Paolillo, K. Ganapathy, S. Sukhadia, J.N. Rosenbaum, R. Daber, J. Morrissette: Validation of a Next-Generation Sequencing Oncology Panel Optimized for Low Input DNA. Cancer Genetics 2018.

A. Oran, J. Grubb, D.B. Lieberman, R.T. Sussman, J.J. Morrissette, J.N. Rosenbaum.: Comparison of ALK, RET, and ROS1 Gene Fusion Detection by Next-Generation Sequencing, Fluorescence in situ Hybridization, and Immunohistochemistry in Non-Small Cell Lung Cancer. Journal of Molecular Diagnostics 16(699), November 2017.

P.R. Hess, P.D. Velu, A. Bigdeli, J.J. Morrissette, J.N. Rosenbaum, J. Roth: Discordance Among Biomarkers for Anti-PD1 Therapy Response: Tumor Mutational Burden and Anti-PD-L1 Staining. Journal of Molecular Diagnostics 16(699), November 2017.

P. Velu, A. Bigdeli, P.R. Hess, J.J. Roth, J.N. Rosenbaum, J.J. Morrissette: Calculation of Mutational Burden in a Clinical Targeted Next-Generation Sequencing (NGS) Panel for Solid Tumors. Journal of Molecular Diagnostics 16(699), November 2017.

A. Bigdeli, R. Sussman, A. Schrank-Hacker, V. Aikawa, J. Rosenbaum, J.D. Morrissette, R.B. Faryabi : Evaluation of Copy Number Variation Detection Methods for Amplicon Sequencing Assays Journal of Molecular Diagnostics 16(699), November 2017.

C. Paolillo, A. Oran, J.N. Rosenbaum, J.J. Morrissette, R. Sussman. : Detection of MET Exon 14 Skipping in Non-Small Cell Lung Cancer (NSCLC) via RNA Anchored Multiplexed PCR and DNA Next-Generation Sequencing. Journal of Molecular Diagnostics 16(699), November 2017.

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Last updated: 08/16/2018
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