Vera Moiseenkova-Bell, PhD

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Associate Professor of Pharmacology
Faculty Director, Electron Microscopy Resource Laboratory and Beckman Center for Cryo Electron Microscopy, University of Pennsylvania
Department: Pharmacology

Contact information
Department of Systems Pharmacology and Translational Therapeutics
University of Pennsylvania, Perelman School of Medicine
10-124 Smilow Center for Translational Research
3400 Civic Center Boulevard, Building 421
Philadelphia, PA 19104-5158
Office: 215 898-1154
MS (Laser Biophysics)
M.V. Lomonosov Moscow State University, 1999.
PhD (Cellular Physiology & Molecular Biophysics)
The University of Texas Medical Branch, 2004.
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Selected Publications

Pumroy R.A., Samanta A., Liu Y., Hughes T., Zhao S., Yudin Y., Rohacs T., Han S., Moiseenkova-Bell V.Y. : Molecular mechanism of TRPV2 channel modulation by cannabidiol. eLife 2019.

Hughes T.E.T., del Rosario J., Kapoor A., Yazici A.T., Fluck E.C., Filizola M., Rohacs T., Moiseenkova-Bell V.Y. : Structure-based discovery of novel TRPV5 inhibitors. eLife 2019.

Fricke T.C., Echtermeyer F., Zielke J., de la Roche J., Filipovic M.R., Claverol S., Herzog C., Tominaga M., Pumroy R.A., Moiseenkova-Bell V.Y., Zygmunt P., Leffler A., Eberhardt M.J. : Oxidation of methionine residues activates the high-threshold heat-sensitive ion channel TRPV2. PNAS 2019.

2. Hughes T.E.T., Pumroy R.A., Yazici A.T., Kasimova M.A., Fluck E.C., Huynh K.W., Samanta A., Molugu S., Zhou Z.H., Carnevale V., Rohacs T., Moiseenkova-Bell V.Y. : Structural insights on TRPV5 gating by endogenous modulators. Nature Communications 9 (1):4198, October 2018.

Samanta A., Hughes T., Moiseenkova-Bell V.Y: Transient Receptor Potential (TRP) Channels. Subcell Biochemistry Membrane-bound Macromolecular Protein Complexes: Structure and Function, Springer 87: 141-165, February 2018.

Basak S., Gicheru Y., Samanta A., Molugu S.K.,, Huang W., de la Fuente M., Hughes T., Taylor D.J., Nieman M.T., Moiseenkova-Bell V.Y., Chakrapani S. : Cryo-EM structure of 5-HT3A receptor in its resting conformation. Nature Communications 514: doi:10.1038/s41467-018-02997-4. February 2018.

Hughes T.E.T., Lodowski D.T., Huynh K.W., del Rosario J., Yazici A., Kapoor A., Basak S., Samanta A., Chakrapani S., Zhou Z.H., Filizola M., Rohacs T., Han S., Moiseenkova-Bell V.Y. : Structural basis of the TRPV5 channel inhibition revealed by cryo-EM. Nature Structural & Molecular Biology. Nature Structural & Molecular Biology, 1: 53-60, January 2018.

Samanta A., Hughes T.E.T., Moiseenkova-Bell V.Y. : Cryo electron microscopy of TRP channels. Methods in Molecular Biology, Springer 2018 Notes: in press.

Samanta A., Kiselar J., Han S., Moiseenkova-Bell V.Y.: Structural insights into the molecular mechanism of mouse TRPA1 activation and inhibition. The Journal of General Physiology 2018 Notes: in press.

Arne J.M., Widjaja-Adhi M.A., Hughes T., Huynh K.W., Silvaroli J.A., Chelstowska S., Moiseenkova-Bell V.Y., Golczak M.: Allosteric modulation of the substrate specificity of acyl-CoA wax alcohol acyltransferase 2 (AWAT2). Journal of Lipid Research 58(4): 719-730, 2017 Notes: doi: 10.1194/jlr.M073692, Epub Jan 17 2017.

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Last updated: 11/19/2019
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