Vera Moiseenkova-Bell, PhD

faculty photo
Associate Professor of Pharmacology
Faculty Director, Electron Microscopy Resource Laboratory and Beckman Center for Cryo Electron Microscopy, University of Pennsylvania
Department: Pharmacology

Contact information
Department of Systems Pharmacology and Translational Therapeutics
University of Pennsylvania, Perelman School of Medicine
10-124 Smilow Center for Translational Research
3400 Civic Center Boulevard, Building 421
Philadelphia, PA 19104-5158
Office: 215 898-1154
Education:
MS (Laser Biophysics)
M.V. Lomonosov Moscow State University, 1999.
PhD (Cellular Physiology & Molecular Biophysics)
The University of Texas Medical Branch, 2004.
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Selected Publications

Pumroy R.A., Fluck E.C., Ahmed T., Moiseenkova-Bell V.Y. : Structural insights into the gating mechanisms of TRPV channels. Cell Calcium 87: 102168, May 2020 Notes: doi: 10.1016/j.ceca.2020.102168. Epub 2020 Jan 24.

Xu Z., Wise M.C., Chokkalingam N., Walker S., Tello-Ruiz E., Elliott S., Perales-Puchalt A., Xiao P., Zhu X., Pumroy R.A., Fisher P.D., Schultheis K., Schade E., Menis S., Guzman S., Andersen H., Broderick K.E., Humeau L.M., Muthumani K., Moiseenkova-Bell V.Y., Schief W.R., Weiner D.B., Kulp D.W. : Achieved through Synergy of Structure‚ÄźBased Protein Engineering and Synthetic DNA Generates Enhanced Adaptive Immunity. Advanced Science Feb 2020 Notes: doi.org/10.1002/advs.201902802.

Fricke T.C., Echtermeyer F., Zielke J., de la Roche J., Filipovic M.R., Claverol S., Herzog C., Tominaga M., Pumroy R.A., Moiseenkova-Bell V.Y., Zygmunt P., Leffler A., Eberhardt M.J. : Oxidation of methionine residues activates the high-threshold heat-sensitive ion channel TRPV2. PNAS 116(48): 24359-24365, Nov 2019 Notes: doi: 10.1073/pnas.1904332116. Epub 2019 Nov 12.

Hughes T.E.T., del Rosario J., Kapoor A., Yazici A.T., Fluck E.C., Filizola M., Rohacs T., Moiseenkova-Bell V.Y. : Structure-based discovery of novel TRPV5 inhibitors. eLife 8, Oct 2019 Notes: pii: e49572. doi: 10.7554/eLife.49572.

Pumroy R.A., Samanta A., Liu Y., Hughes T., Zhao S., Yudin Y., Rohacs T., Han S., Moiseenkova-Bell V.Y. : Molecular mechanism of TRPV2 channel modulation by cannabidiol. eLife 8, Sep 2019 Notes: pii: e48792. doi: 10.7554/eLife.48792.

Samanta A., Hughes T.E.T., Moiseenkova-Bell V.Y. : Cryo electron microscopy of TRP channels. Methods in Molecular Biology, Springer(1987), 39-50, 2019 Notes: doi: 10.1007/978-1-4939-9446-5_3.

2. Hughes T.E.T., Pumroy R.A., Yazici A.T., Kasimova M.A., Fluck E.C., Huynh K.W., Samanta A., Molugu S., Zhou Z.H., Carnevale V., Rohacs T., Moiseenkova-Bell V.Y. : Structural insights on TRPV5 gating by endogenous modulators. Nature Communications 9 (1):4198, October 2018.

Samanta A., Kiselar J., Han S., Moiseenkova-Bell V.Y.: Structural insights into the molecular mechanism of mouse TRPA1 activation and inhibition. The Journal of General Physiology 150(5): 751-762, May 2018 Notes: doi: 10.1085/jgp.201711876. Epub 2018 Apr 27.

Samanta A., Hughes T., Moiseenkova-Bell V.Y: Transient Receptor Potential (TRP) Channels. Subcell Biochemistry Membrane-bound Macromolecular Protein Complexes: Structure and Function, Springer 87: 141-165, February 2018.

Basak S., Gicheru Y., Samanta A., Molugu S.K.,, Huang W., de la Fuente M., Hughes T., Taylor D.J., Nieman M.T., Moiseenkova-Bell V.Y., Chakrapani S. : Cryo-EM structure of 5-HT3A receptor in its resting conformation. Nature Communications 514: doi:10.1038/s41467-018-02997-4. February 2018.

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Last updated: 05/27/2020
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