Department of Anesthesiology and Critical Care

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William M. Armstead, BA, MS, PhD

Research Professor of Anesthesiology and Critical Care
Member, Institute of Neurological Sciences, University of Pennsylvania
Member, Cardiovascular Institute, University of Pennsylvania
Department: Anesthesiology and Critical Care

Contact information
Department of Anesthesiology and Critical Care
3620 Hamilton Walk, JM3
Philadelphia, PA 19104-4283
Office: 215-573-3674
Fax: 215-349-5078
Graduate Group Affiliations
Education:
B.A. (Biochemistry)
University of Pennsylvania, 1979.
M.S. (Pharmacology)
Tulane University, 1983.
Ph.D. (Pharmacology)
Tulane University, 1985.
Post-Graduate Training
Postdoctoral Fellow/Instructor, Department of Pharmacology , Tulane University, 1985-1986.
Postdoctoral Fellow, Department of Physiology and Biophysics, University of Tennessee, Memphis, TN, 1986-1988.
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Description of Research Expertise

Research Interests
Control of cerebral hemodynamics during physiologic and pathologic conditions such as traumatic brain injury, stroke, and cerebral ischemia/reperfusion.


Research Techniques
Closed cranial window for measurement of pial artery diameter and collection of cortical periarachnoid CSF for vasoactive metabolite concentration determination by RIA, fluid percussion brain injury, global cerebral ischemia, photothrombotic cerebral injury, radiolabelled microsphere regional cerebral blood flow determination.


Research Summary
Dr. Armstead's research focuses on characterizing mechanisms important in the control of cerebral hemodynamics under physiologic and pathologic conditions such as traumatic brain injury (TBI), stroke, and cerebral hypoxia/ischemia, particularly in the newborn. Current projects focus on interactions between the NMDA receptor and plasminogen activators after TBI, optimizing the efficacy/toxicity ratio of tPA, the only FDA approved treatment for stroke and translational research concerning the roles of sex and age in outcome after pediatric TBI.

Key Words
tPA, adrenomedullin, newborn, brain injury, stroke, endothelin, nitric oxide, cerebral circulation

Selected Publications

Armstead WM, Hekierski H, Pastor, Yarovoi S, Higazai AAR, Cines DB.: Release of IL-6 after stroke contributes to impaired cerebral autoregulation and hippocampal neuronal necrosis through NMDA receptor activation and upregulation of ET-1 and JNK. Translational Stroke Research 10: 104-111, 2019.

Curvello V, Pastor P, Hekierksi H, Armstead WM: Inhaled nitric oxide protects cerebral autoregulation and reduces hippocampal necrosis after traumatic brain injury through inhibition of ET-1, ERK MAPK, and IL-6 upregulation in pigs. Neurocritical Care 30: 467-477, 2019.

Armstead WM. Vavilala MS: Cerebral perfusion pressure directed therapy modulates cardiac dysfunction after traumatic brain injury to influence cerebral autoregulation in pigs. Neurocritical Care 31: 476-485, 2019.

Armstead WM., Vavilala MS.: Propranolol protects cerebral autoregulation and reduces hippocampal neuronal cell death through inhibition of IL-6 upregulation after traumatic brain injury in pigs. British J Anesthesia 123: 610-617, 2019 Notes:

Pastor P, Curvello V, Hekierski H, Armstead WM: Inhaled nitric oxide protects cerebral autoregulation through prevention of impairment of ATP and calcium sensitive K channel mediated cerebrovasodilation after traumatic brain injury. Brain Research 1711: 1-6, 2019.

Curvello V, Hekierski H, Pastor P, Vavilala M, Armstead WM. : Dopamine protects cerebral autoregulation and prevents hippocampal necrosis after traumatic brain injury via block of ERK MAPK in juvenile pigs. Brain Research 1670: 118-124, 2017.

Curvello V, Hekierski H, Riley J, Vavilala M, Armstead WM.: Sex and age differences in phenylephrine mechanisms and outcomes after piglet brain injury. Ped Res 82: 108-113, 2017.

Armstead WM, Riley J, Vavilala MS.: K channel impairment determines sex and age differences in epinephrine-mediated outcomes after brain injury. J of Neuroscience Research 95: 1917-1926, 2017.

Armstead WM, Riley J, Vavilala M: Sex and age differences in epinephrine mechanisms and outcomes after brain injury. J Neurotrauma 34: 1666-1675, 2017.

Armstead WM, Hekierski H, Yarovoi S, Higazi AAR, Cines DB. : tPA-A296-299 prevents impairment of cerebral autoregulation and necrosis of hippocampal neurons after stroke by inhibiting upregulation of ET-1. J of Neuroscience Research 96: 128-137, 2017.

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Last updated: 12/09/2019
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