Department of Anesthesiology and Critical Care

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Max B. Kelz, MD PhD

Anesthesia Distinguished Professor
Chair of Admissions MD PhD Neuroscience Graduate Group, University of Pennsylvania, Perelman School of Medicine
MSTP Program Advisor, University of Pennsylvania
Director for Research Education, Department of Anesthesiology, University of Pennsylvania, Perelman School of Medicine
Director, Dripps Research Fellowship Program, University of Pennsylvania
Founding Director NEURRAL Center, University of Pennsylvania, Perelman School of Medicine
MSTP Program Steering Committee, University of Pennsylvania
Department: Anesthesiology and Critical Care

Contact information
3620 Hamilton Walk,
John Morgan Building - Room 334
Philadelphia, PA 19104
Office: 215 573-8208
Fax: 215 349-5078
Lab: 215 898-8929
Graduate Group Affiliations
MS (Molecular Biophysics and Biochemistry)
Yale University, 1993.
BS (Molecular Biophysics and Biochemistry)
Yale University, 1993.
PhD (Neuroscience)
Yale University, 1999.
MD (Medicine)
Yale University, 2000.
Post-Graduate Training
Transitional Internship, University of Pennsylvania Perelman School of Medicine, 2000-2001.
Resident in Anesthesiology, University of Pennsylvania Perelman School of Medicine, 2001-2004.
Diplomat, National Board of Medical Examiners, 2001.
Diplomat, American Board of Anesthesiology, 2005.
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Description of Research Expertise

Molecular Mechanisms of Anesthetic Action
Neurobiology of Sleep Wake Regulation
Mouse Genetics
Molecular Biology
Anesthetic pharmacology

Description of Clinical Expertise


Selected Publications

Rokos A, Mišić B, Berkun K, Duclos C, Tarnal V, Janke E, Picton P, Golmirzaie G, Basner M, Avidan MS, Kelz MB, Mashour GA, Blain-Moraes S.: Distinct and Dissociable EEG Networks Are Associated With Recovery of Cognitive Function Following Anesthesia-Induced Unconsciousness. Front Hum Neurosci 15: 706693, Sep 2021.

Duclos C, Maschke C, Mahdid Y, Berkun K, Castanheira JDS, Tarnal V, Picton P, Vanini G, Golmirzaie G, Janke E, Avidan MS, Kelz MB, Liuzzi L, Brookes MJ, Mashour GA, Blain-Moraes S.: Differential classification of states of consciousness using envelope- and phase-based functional connectivity. Neuroimage euroimage, Aug 2021.

Cieslak M, Cook PA, He X, Yeh F-C, Dhollander T, Adebimpe A, Aguirre GK, Bassett DS, Betzel RF, Bourque J, Cabral LM, Davatzikos C, Detre JA, Earl E, Elliott MA, Fadnavis S, Fair DA, Foran W, Fotiadis P, Garyfallidis E, Giesbrecht B, Gur RC, Gur RE, Kelz MB, Keshavan A, Larsen BS, Luna B, Mackey AP, Milham MP, Oathes DJ, Perrone A, Pines AR, Roalf DR, Richie-Halford A, Rokem A, Sydnor VJ, Tapera TM, Tooley UA, Vettel JM, Yeatman JD, Grafton ST, Satterthwaite TD: QSIPrep: an integrative platform for preprocessing and reconstructing diffusion MRI data. Nat Methods 18(7): 775-8, July 2021.

Mashour GA, Palanca BJ, Basner M, Li D, Wang W, Blain-Moraes S, Lin N, Maier K, Muench M, Tarnal V, Vanini G, Ochroch EA, Hogg R, Schwartz M, Maybrier H, Hardie R, Janke E, Golmirzaie G, Picton P, McKinstry-Wu AR, Avidan MS, Kelz MB.: Recovery of consciousness and cognition after general anesthesia in humans. Elife 10: e59525, May 2021.

Duclos C, Nadin D, Mahdid Y, Tarnal V, Picton P, Vanini G, Golmirzaie G, Janke E, Avidan MS, Kelz MB, Mashour GA, Blain-Moraes S: Brain network motifs are markers of loss and recovery of consciousness. Sci Rep 11(1): 3892, Feb 2021.

Venincasa MJ, Randlett O, Sumathipala SH, Bindernagel R, Stark MJ, Yan Q, Sloan SA, Buglo E, Meng QC, Engert F, Züchner S, Kelz MB, Syed S, Dallman JE.: Elevated preoptic brain activity in zebrafish glial glycine transporter mutants is linked to lethargy-like behaviors and delayed emergence from anesthesia. Sci Rep 11(1): 3148, Feb 2021.

Ramayya AG, Yang AI, Buch VP, Burke JF, Richardson AG, Brandon C, Stein JM, Davis KA, Chen HI, Proekt A, Kelz MB, Litt B, Gold JI, Lucas TH.: Theta synchrony is increased near neural populations that are active when initiating instructed movement. eNeuro 8(1): 1-14, Feb 2021.

Proekt A and Kelz MB: Explaining anaesthetic hysteresis with effect-site equilibration. Br J Anaesth 126(1): 265-278, Jan 2021 Notes: Comment in Resisting neural inertia: an exercise in floccinaucinihilipilification? Eleveld DJ, Colin PJ, Absalom AR, Struys MMRF. Br J Anaesth. 2021 Jan;126(1):31-34.

Reitz SL, Wasilczuk AZ, Beh GH, Proekt A, Kelz MB: Activation of Preoptic Tachykinin 1 Neurons Promotes Wakefulness Over Sleep and Volatile Anesthetic-Induced Unconsciousness. Current Biology 31(2): 394-405, Jan 2021.

Culley DJ, Kelz MB, Koch CG, Eisenach JC, Neuman MD, Whitlock EL, Robertson RM, Cooper T, Pomerans P: Creation of the Anesthesia Research Council Anesth Analg. 131(4): 1300-1303, Oct 2020.

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Last updated: 11/16/2021
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