Department of Anesthesiology and Critical Care

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Huafeng Wei, MD, PhD

Associate Professor of Anesthesiology and Critical Care
Attending Anesthesiologist, Hospital of the University of Pennsylvania
Department: Anesthesiology and Critical Care

Contact information
Department of Anesthesiology and Critical Care Medicine
University of Pennsylvania
305 John Morgan Building
3620 Hamilton Walk
Philadelphia, PA 19104-6112
Office: 215-260-9840
Fax: 215-349-5078
Lab: 215-746-8704
Diploma (Medicine)
Jining Medical School, Jining, China, 1982.
MD (Medicine)
Tongji Medical University, Wuhan, China, 1988.
PhD (Pharmacology and Toxicology)
George Washington University, Washington, DC, 1996.
Post-Graduate Training
Resident in Anesthesiology, Department of Anesthesia, Shandong Provincial Hospital, Jinan, China, 1982-1985.
Fellow in Anesthesia, Tongji Medical University, Wuhan, Hubei, China, 1985-1988.
Fellow in Pharmacology, George Washington University Medical Center, Washington, DC, 1993-1996.
Postdoctoral Fellow, Georgetown Institute for Cognitive and Computational Sciences (GICCS), Georgetown University Medical School, Washington, DC, 1996-1997.
IRTA Postdoctoral Fellow in Molecular Neurobiology, National Institute of Mental Health, NIH, Bethesda, MD, 1997-1999.
Transitional Internship, Presbyterian Medical Center, Philadelphia, PA, 1999-2000.
Resident in Anesthesia, Hospital of the University of Pennsylvania, Philadelphia, PA, 2000-2003.
Board Certified, American Board of Anesthesiology (ABA), 2004.
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Description of Research Expertise

Basic science: Role of intracellular calcium dysregulation on neuronal apoptosis, autophagy and neurodegenration in neurodegenerative diseases, especially in Alzheimer's Disease. Treatment of Alzheimer's disease. Mechanisms of anesthesia mediated neurotoxicity and neurodegeneration, especially in the developing brains and in Alzheimer's disease.

Clincal science: Clinical use of Supraglottic Jet Oxygenationa and Ventilation (SJOV) in difficult airway management.

Description of Clinical Expertise

General practice of anesthesia, Difficult airway management, Clinical use of Supraglottic Jet Oxygenation and Ventilation (SJOV)

Description of Other Expertise

Taichi (one type of Chinese Kungfu Master. Total six gold medals, five silver medals and two brown model on various international Wushu (Kungfu) competitions.

Selected Publications

Yang ZY, Xu YH, Meng Q, Wang JW, YU DS, Wei HF: Supraglottic jet oxygenation and ventilation during colonoscopy under monitored anesthesia care: a controlled randomized clinical trial. European Review for Medical and Pharmacological Sciences 20: 1168-73, 2016.

Li Q, Xie P, Zha B, Wu JY, Wei H. : Supraglottic jet oxygenation and ventilation saved a patient with 'cannot intubate and cannot ventilate' emergent difficult airway. Journal of Anesthesia 31: 144-147, 2017.

Wu, Z, Yang B, Liu C, Liang G, Liu W, Pickup S, Meng Q, Tian, Y, Li S, Eckenhoff M, Wei H: Long term dantrolene treatment reduced intraneuronal amyloid in aged Alzheimer triple transgenic mice. Alzheimer's Disease and Associated Disorders 29: 184-191, 2015.

Wu CN, Ma WH, Wei JQ, Wei HF, Cen QY, Cai QX, Cao Y: Laryngoscope and a New Tracheal Tube Assist Lightwand Intubation in Difficult Airways due to Unstable Cervical Spine. PLoS One 10: doi: 10.1371/journal.pone.0120231, 2015.

Liang L, Wei H: Dantrolene, A treatment for Alzheimer’s disease? Alzheimer Disease and Associated Disorders 29: 1-5, 2015.

Levitt C, Wei H: Supraglotic pulsatile jet oxygenation and ventilation during deep propofol sedation for upper gastrointestinal endoscopy in a morbidly obese patient. Journal of Clinical Anesthesia 26: 157-9, 2014.

Yang B, Liang G, Khojasteh S, Wu Z, Joseph D, Wei H.: Comparison of neurodegeneration and cognitive impairment in neonatal mice exposed to propofol or isoflurane. PLoS One 9: e99171. doi: 10.1371/journal.pone.0099171, 2014.

Peng J, Drobish JK, Liang G, Wu Z, Liu C, Joseph D, Abdou H, Eckenhoff M, Wei H : Anesthetic preconditioning inhibits isoflurane-mediated apoptosis in the developing rat brain. Anesthesia and Analgesia 119: 939-46, 2014.

Joseph DJ, Peng Y, Mak DD, Cheung KH, Vais H, Foskett JK, Wei H : General anesthetic isoflurane modulates inositol 1,4,5-trisphosphate receptor calcium channel opening. Anesthesiology 121: 528-37, 2014.

Wei H, Inan S: Dual effects of neuroprotection and neurotoxicity by general anesthetics: Role of intracellular calcium homeostasis. Progress in Neuropsychopharmacology and Biological Psychiatry 1833: 2499-2510, 2013.

Zhao X, Yang Z, Liang G, Wu Z, Peng Y, Joseph DJ, Inan S, Wei H: Dual effects of isoflurane on proliferation, differentiation and survival in human neuroprogenitor cells Anesthesiology 118(3): 537-549, 2013 Notes: With editorial.

Peng J, Ye J, Zhao Y, Liang J, Huang H, Wei H, Peng S: Supraglottic jet ventilation in difficult airway management. Journal of Emergency Medicine 43: 382-90, 2012.

Peng J, Liang G, Inan S, Wu Z, Joseph D, Meng Q, Peng Y, Eckenhoff M, Wei H: Dantrolene ameliorates cognitive decline and neuropathology in Alzheimer triple transgenic mice. Neuroscience Letter 516: 274-279, 2012.

Dziewit JA, Wei H: Supraglottic Jet Ventilation Assists Intubation in a Marfan’s Syndrome Patient with a Difficult Airway. Journal of Clinical Anesthesia 23: 407-409, 2011.

Wei H: Role of calcium dysregulation in anesthetics mediated neurotoxicity. Anesthesia and Analgesia 113: 972-974, 2011 Notes: Invited Editorial.

Wang Q, Liang G, Yang H, Wang S, Eckenhoff MF, Wei H: The common inhaled anesthetic isoflurane increases aggregation of huntingtin and alters calcium homeostasis in a cell model of Huntington's disease. Toxicology and Applied Pharmacology 250: 291-298, 2011.

Liang G, Ward C, Peng J, Zhao Y, Huang B, Wei H: Isoflurane causes greater nenurodegeneration than an equivalent exposure of sevoflurane in the developing brains of neonatal Mice. Anesthesiology 112: 1325-34, 2010.

Inan S, Wei H: Cytoprotective effects of dantrolene: a ryanodine receptor antagonist. Anesthesia and Analgesia 111: 1400-10, 2010.

Zhao Y, Liang G, Chen Q, Joseph DJ, Meng Q, Eckenhoff RG, Eckenhoff MF, Wei H: Anesthetic induces neurodegeneration mediated via inositol 1,4,5-trisphosphate receptors. The Journal of Pharmacology and Experimental Therapeutics 333: 1-9, 2010.

Wei H, Xie Z: Anesthesia, calcium homeostasis and Alzheimer's disease. Current Alzheimer Research 6: 30-35, 2009.

Wang S, Peretich K, Zhao Y, Liang G, Meng Q, Wei H: Anesthesia-induced neurodegeneration in fetal rat brains. Pediatric Research 66: 435-440, 2009.

Liang G, Wang Q, Li Y, Kang B, Eckenhoff MF, Eckenhoff RG, Wei H: A Presenilin-1 mutation renders neurons vulnerable to isoflurane toxicity. Anesthesia and Analgesia 106: 492-500, 2008.

Yang H, Liang G, Hawkins B, Madesh M, Pierwola A, Wei H: Inhalational anesthetics induce cell damage by disruption of intracellular calcium homeostasis with different potencies. Anesthesiology 109: 243-50, 2008.

Wei H, Liang G, Yang H, Wang Q, Hawkins B, Madesh M, Wang S, Eckenhoff RG: The common inhalational anesthetic isoflurane induces apoptosis via activation of inositol 1,4,5-trisphosphate receptors. Anesthesiology 108: 251-60, 2008.

Wei H, Jin S, Ma l, Bi H, Ba X: Experimental study of high frequency two-way jet ventilation. Critical Care Medicine 20: 420-423, 1992.

Perry DC, Wei H, Rosenthal RE, Fiskum G: Autoradiographic analysis of L- and N-type voltage-dependent calcium channel binding in canine brain after global cerebral ischemia reperfusion. Brain Research 657: 65-72, 1994.

Wei H, Perry DC: Dantrolene is cytoprotective in two models of neuronal cell death. Journal of Neurochemistry 67(6): 2390-2398, 1996.

Wei H, Fiskum G, Rosenthal RE, Perry DC: Global cerebral ischemia and reperfusion alters NMDA receptor binding in canine brain. Molecular Chemical Neuropathology 30: 25-39, 1997.

Wei H, Wei W, Bredesen D, Perry DC: Bcl-2 inhibits apoptosis induced by depletion of calcium from endoplasmic reticulum. Journal of Neurochemistry 70: 2305-2314, 1998.

Chen RW, Saunders PA, Wei H, Li Z, Seth P, Chuang DM: Involvement ofGlyceraldehyde-3Phosphate Dehydrogenase (GAPDH) and p53 in neuronal apoptosis: Evidence that GAPDH is upregulated by p53. The Journal of Neuroscience 19(21): 9654-9662, 1999.

Wei H, Leeds P, Chen RW, Wei W, Leng Y, Bredesen DE, Chuang DM: Neuronal apoptosis induced by pharmacological concentrations of 3-Hydroxykynurenine: Characterization and protection by dantrolene and Bcl-2 overexpression. Journal of Neurochemistry 75: 81-90, 2000.

Wei H, Leeds PR, Qian Y, Wei W, Chen RW, Chuang DM: ß-amyloid peptide-induced death of PC 12 cells and cerebellar granule cell neurons is inhibited by long-term lithium treatment. European Journal of Pharmacology 392: 117-123, 2000.

Wei H, Qin, ZH, Senatorov VV, Wei W, Wang Y, Qian Y, Chuang DM: Lithium suppresses excitotoxicity-induced striatal lesions in a rat model of Huntington's disease. Neuroscience 106(3): 603-612, 2001.

Senatorov VV, Ren M, Kanai H, Wei H, Chuang DM : Short-term lithium treatment promotes neuronal survival and proliferation in rat striatum infused with quinolinic acid, an excitotoxic model of Huntington's disease. Molecular Psychiatry. Nature Publishing Group, Page: 1-15, 2004.

Wei H, Kang B, Wei W, Liang G, Meng QC, Li Y, Eckenhoff RG: Isoflurane and sevoflurane affect cell survival and Bcl-2/Bax ratio differently. Brain Research 1037: 139-147, 2005.

Eckehnoff RG, Johansson JS, Wei H, Carnini A, Kang B, Wei W, Pidikiti R, Keller JM, Eckenhoff MF: Inhaled Anesthetic Enhancement of Amyloid-beta oligomerization and cytotoxicity. Anesthesiology 101(3): 703-9, 2004.

Hiroi T, Wei H, Hough C, Leeds P, Chuang DM: Protracted lithium treatment protects against the ER stress elicited by thapsigargin in rat PC12 cells: roles of intracellular calcium, GRP 78 and Bcl-2. The Pharmacogenomics Journal Nature Publishing Group, Page: 1-10, 2005.

Wei H: A novel endotracheal tube and methods to facilitate ventilation and placement in emergent airway management. Resuscitation. 70: 438-444, 2006.

Wei H, Liang G, Yang H: Isoflurane preconditioning inhibited isoflurane-induced neurotoxicity. Neuroscience Letter 425: 59-62, 2007.

Li Y, Liang G, Wang S, Meng Q, Wang Q, Wei H: Effects of fetal exposure to isoflurane on postnatal memory and learning in rats. Neuropharmacology 53: 942-950, 2007.

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Last updated: 01/06/2020
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