faculty photo

Rizwan S Akhtar, MD, PhD

Assistant Professor of Neurology at the Pennsylvania Hospital
Attending Neurologist, Pennsylvania Hospital, University of Pennsylvania Health System
Attending Neurologist, Hospital of the University of Pennsylvania, University of Pennsylvania Health System
Attending Neurologist, Penn Presbyterian Medical Center, University of Pennsylvania Health System
Department: Neurology

Contact information
330 South 9th St, Fourth Floor
Penn Medicine Pennsylvania Hospital
Philadelphia, PA 19107
Office: 2158296500
Fax: 2158296606
BS (Molecular Biology / Psychology)
Vanderbilt University, 2000.
PhD (Neurobiology)
University of Alabama at Birmingham, 2007.
MD (Medicine)
University of Alabama at Birmingham, 2007.
Post-Graduate Training
Resident in Internal Medicine, University of Alabama at Birmingham, 2007-2008.
Resident in Neurology, University of Pennsylvania, 2008-2011.
Fellow in Movement Disorders, University of Pennsylvania, 2011-2013.
Postdoctoral Fellow in Neurodegenerative Disease, University of Pennsylvania, 2012-2017.
American Board of Psychiatry and Neurology, 2011.
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Description of Clinical Expertise

Movement disorders, including Parkinson's disease, atypical parkinsonism, dystonia, ataxia, blepharospasm, and essential tremor.

Description of Research Expertise

Development of α-synuclein and amyloid-β biomarkers for Parkinson's disease and related neurodegenerative diseases.

Selected Publications

Irwin DJ, Xie SX, Coughlin D, Nevler N, Akhtar RS, McMillan CT, Lee EB, Wolk DA, Weintraub D, Chen-Plotkin AS, Duda JE, Spindler M, Siderowf AD, Hurtig HI, Shaw LM, Grossman M, Trojanowski JQ: CSF tau and amyloid-β predict cerebral synucleinopathy in autopsied Lewy Body disorders. Neurology 90(12): e1038-e1046, Mar 2018 Notes: doi: 10.1212/WNL.0000000000005166.

Akhtar RS, Licata JP, Luk KC, Shaw LM, Trojanowski JQ, Lee VM.: Measurements of auto-antibodies to α-synuclein in the serum and cerebral spinal fluids of patients with Parkinson's disease. Journal of Neurochemistry 145(6): 489-503, Jun 2018 Notes: doi: 10.1111/jnc.14330.

Covell DJ, Robinson JL, Akhtar RS, Grossman M, Weintraub D, Bucklin HM, Pitkin RM, Riddle D, Yousef A, Trojanowski JQ, and Lee VM: Novel conformation-selective alpha-synuclein antibodies raised against different in vitro fibril forms show distinct patterns of Lewy pathology in Parkinson’s disease. Neuropathology and Applied Neurobiology 43(7): 604-620, Dec 2017 Notes: doi: 10.1111/nan.12402.

Akhtar RS, Licata JP, Luk KC, Covell DJ, Trojanowski JQ, Lee VM: Epitope mapping of CSF auto-antibodies to α-synuclein. Movement Disorders 32(suppl 2): S231, Jun 2017.

Akhtar RS, Xie SX, Chen YJ, Rick J, Gross RG, Nasrallah IM, Van Deerlin VM, Trojanowski JQ, Chen-Plotkin AS, Hurtig HI, Siderowf AD, Dubroff JG, Weintraub D: Regional brain amyloid-β accumulation associates with domain-specific cognitive performance in Parkinson disease without dementia. PLoS One 12(5): e0177924, May 2017 Notes: doi:10.1371/pone.0177924.

Akhtar RS, Xie SX, Brennan L, Pontecorvo MJ, Hurtig HI, Trojanowski JQ, Weintraub D, and Siderowf AD: Amyloid-β PET imaging of Alzheimer pathology in Parkinson disease dementia. Movement Disorders Clinical Practice 3(4): 367-375, Jul-Aug 2016.

Pigott K, Rick J, Xie SX, Hurtig HI, Chen-Plotkin AS, Duda JE, Morley JF, Chahine LM, Dahodwala N, Akhtar RS, Siderowf AD, Trojanowski JQ, and Weintraub D: Longitudinal study of normal cognition in Parkinson’s Disease. Neurology 85(15): 1276-1282, Oct 2015.

Akhtar RS, Stern MB: New concepts in the early and preclinical detection of Parkinson's disease: therapeutic implications. Expert Review of Neurotherapeutics 12(12): 1429-1438, Dec 2012.

Akhtar RS, Horn SS: Psychiatric manifestations of common neurologic disorders. Principles and Practice of Geriatric Psychiatry 2 ed. Agronin ME, Maletta GJ (eds.). Lippincott, Williams & Wilkins, Philadelphia, Pennsylvania, Page: 735-744, 2011.

Akhtar RS, Latham CB, Siniscalco D, Fuccio C, Roth KA: Immunohistochemical detection with quantum dots. Methods in Molecular Biology. Hotz C, Bruchez Jr. M (eds.). Humana Press, Totowa, New Jersey, 374: 11-28, 2007.

Akhtar RS, Klocke BJ, Strasser A, Roth KA: Loss of BH3-only protein Bim inhibits apoptosis of hemopoietic cells in the fetal liver and male germ cells but not neuronal cells in bcl-x-deficient mice. Journal of Histochemistry and Cytochemistry 56(10): 921-927, Oct 2008.

Akhtar RS, Geng Y, Klocke BJ, Roth KA: Neural precursor cells possess multiple p53-dependent apoptotic pathways. Cell Death and Differentiation 13(10): 1727-1739, Oct 2006.

Akhtar RS, Roth KA: Regulation of neural stem cell death. Neural Development and Stem Cells 2 ed. Rao MS (eds.). Humana Press, Totowa, New Jersey, Page: 97-122, 2006.

Akhtar RS, Geng Y, Klocke BJ, Latham CB, Villunger A, Michalak EM, Strasser A, Carroll SL, Roth KA: BH3-only proapoptotic Bcl-2 family members Noxa and Puma mediate neural precursor cell death. The Journal of Neuroscience 26(27): 7257-7264, Jul 2006.

Ness JM, Akhtar RS, Latham CB, Roth KA: Combined tyramide signal amplification and quantum dots for sensitive and photostable immunofluorescence detection. Journal of Histochemistry and Cytochemistry 51(8): 981-987, Aug 2003.

Akhtar RS, Ness JM, Roth KA: Bcl-2 family regulation of neuronal development and neurodegeneration. Biochimica et Biophysica Acta 1644(2-3): 189-203, Mar 2004.

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Last updated: 09/29/2019
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