Department of Neurology

Department of Neurology
faculty photo

Hongyu Sun, MD, PhD

Research Assistant Professor of Neurology
Department: Neurology

Contact information
Perelman School of Medicine, University of Pennsylvania
Department of Neurology
265 Clinical Research Building
413 Curie Boulevard
Philadelphia, PA 19104
Lab: 215-898-0552
Education:
MD (Medicine)
Tianjin Medical University, Tianjin, China, 1997.
MSc (Neuroscience and Neurosurgery)
Tianjin Medical University, Tianjin, China, 2002.
PhD (Neuroscience)
Carleton University, Ottawa, Canada, 2008.
Post-Graduate Training
Intern, Tianjin General Hospital, Tianjin, China, 1996-1997.
Resident, Jixian Hospital, Department of Neurosurgery, Tianjin, China, 1997-1999.
Resident/Fellow, Tianjin General Hospital, Department of Neurosurgery, Tianjin, China, 1999-2002.
Research Assistant, Tianjin Neurological Institute, Tianjin Medical University, Tianjin, China , 1999-2002.
Research Fellow, Tianjin Neurological Institute, Tianjin Medical University, Tianjin, China , 2002-2003.
Research Assistant, Institute of Neuroscience, Carleton University, Ottawa, ON , 2003-2008.
Postdoctoral Research Fellow, Institute of Neuroscience, Carleton University, Ottawa ON , 2008-2009.
Postdoctoral Research Fellow, Department of Neurology, Children's Hospital Boston and Harvard Medical Center, Boston, MA , 2009-2012.
Postdoctoral Research Fellow, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA , 2012-2013.
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Selected Publications

Zhou C*, Sun H*, Klein PM, Jensen FE. : Neonatal seizures alter NMDAR-mediated EPSC properties in hippocampal CA1 neurons. Frontiers in Cellular Neuroscience, 2015.

Sun H, Jensen FE. : Early-life seizures induced synaptic metaplasticity in hippocampal CA1 neurons. SFN annual meeting 2014, Washington DC, USA. 2014.

Sun H, Talos D, Goto J, Juul H, Dreier J, Coley A, Kwiatkowski DJ, Jensen FE. : Bumetanide attenuates neuronal network hyperexcitability and improves survival in a mouse model of tuberous sclerosis. AAN annual meeting 2014, Philadelphia, PA, USA 2014.

Kimmey, B A, Handy, M J, Soldan, S S, Sun H, Jensen, F E.: Perampanel reverses early-life seizure-induced activation of the mTORC1 pathway. SFN annual meeting, Washington DC, USA. 2014.

Sengupta S*, Weeraratne SD*, Sun H, Rallapalli S, Phallen J, Teider N, Pierre-Francois J, Amani V, Tang Y, Nguyen B, Yu F, Schubert S, Mathios D, Lechpammer M, Kosares B, Tran P, Cook JM, Lim M, Pomeroy SL, Jensen FE, Cho YJ. : Chemical synthetic lethality via 5-GABAA receptor activation in MYC-amplified medulloblastomas. Acta Neuropathol, 127(4): 593-603. 2014.

Cleary R, Sun H, Huynh T, Manning SM, Li Y, Rotenberg A, Talos DM, Jackson M, Rakhade SN, Berry G, Jensen FE: Synergistic Anticonvulsant Efficacy of Combination Phenobarbital and NKCC1 Inhibitor Bumetanide Treatment in a Rat Model of Neonatal Seizures. PLoS one Page: 10.1371/journal.pone.0057148, 2013.

Sun H, Kosaras B, Klein PM, Jensen FE: mTORC1 Activation Negatively Regulates PLK2 Mediated Homeostatic Compensation Following Neonatal Seizures. PNAS 110(13): 5199-5204, 2013.

Sun H, Zhou C, Klein P, Jensen FE: Alteration of Extrasynaptic NMDA Receptors Following Early-Life Seizures. Society for Neuroscience Meeting, New Orleans, LA 2012 Notes: Oral Presentation.

Talos, DM, Sun H, Kosaras B, Joseph A, Folkerth RD, Poduri A, Madsen JR, Black PM, Jensen FE: Altered Inhibition in Tuberous Sclerosis and Type IIb Cortical Dysplasia. Ann Neurol 71 (4): 539-551, 2012.

Rakhade SN, Fitzgerald EF, Klein PM, Zhou C, Sun H, Huganir RL, Jensen FE: Glutamate Receptor 1 Phosphorylation at Serine 831 and 845 Modulates Seizure Susceptibility and Hippocampal Hyerexcitability Following Early Life Seizures. Journal of Neuroscience 32(49): 17800-17812, 2012.

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Last updated: 06/23/2015
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