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Timothy H Lucas Jr., M.D., Ph.D.

Assistant Professor of Neurosurgery
Director, Translational Neuromodulation Laboratory, Department of Neurosurgery, University of Pennsylvania
Associate Director, Center for Neuroengineering & Therapeutics, University of Pennsylvania
Department: Neurosurgery

Contact information
3400 Spruce Street
3rd Floor Silverstein
Philadelphia, PA 19104
Office: 215-615-0578
Fax: 215-349-5534
Lab: 215-746-1336
Graduate Group Affiliations
B.S. (Neurobiological Sciences & Psychobiology)
University of Florida, 1996.
M.D. (Medicine)
University of Florida, 2001.
Ph.D. (Physiology & Biophysics)
University of Washington, 2009.
Post-Graduate Training
Intern in General Surgery, University of Washington, 2001-2002.
Resident in Neurological Surgery, University of Washington, 2002-2009.
Specialist Registrar in Neurological Surgery, St. George's National Healthcare Trust, London, England, UK, 2006-2007.
Chief Resident in Neurological Surgery, University of Washington, 2009-2010.
Fellow in Neurosurgical Oncology & Cerebrovascular Neurosurgery, University of Washington, 2010-2010.
Fellow in Neurosurgical Oncology Brain Mapping, University of California San Francisco, 2011-2011.
Clinical Experience in Stereotactic & Functional Neurosurgery, University of California San Francisco, 2011-2011.
American Board of Neurological Surgeons (Board Eligible), 2011.
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Description of Clinical Expertise

Epilepsy Surgery
Temporal Lobectomy
Minimally invasive neurosurgery
Laser Neurosurgery
Endoscopic Surgery
Sports Neurosurgery
Cortisectomy / Topectomy
Corpus Callostomy / Functional Disconnection Surgery
Trigeminal neuralgia
Microvascular decompression
Stereotactic and Functional Neurosurgery
Movement Disorder Surgery (Parkinson's Disease, Essential Tremor, Dystonia)
Glioma Surgery (Low Grade, High Grade, Adult, Pediatric)
Insular Lesions
Brain Mapping (Speech, Motor, Sensory; cortical and subcortical)
Extraoperative Brain Mapping
Brain-machine interface / Brain-computer interface
Spine Disorders
Spinal Fusion
Skull base surgery
Brain Plasticity
Eloquent Cortex Lesions (motor, sensory, speech, visual cortex)
Traumatic brain and spine injury

Description of Research Expertise

Brain-machine interface / Brain-computer interface
Motor Cortex Functional Organization
Voluntary Movement
Speech and Language Organization
Cortical Plasticity
Basal Ganglia - Cortical Interactions
Cortical/Basal Ganglia Stimulation
Cortical Spike and Local Field Recording
Basal Ganglia Spike and Local Field Recording
Spinal Cord Stimulation and Mapping

Selected Publications

Davis Kathryn Adamiak, Nanga Ravi Prakash Reddy, Das Sandhitsu, Chen Stephanie H, Hadar Peter N, Pollard John R, Lucas Timothy H, Shinohara Russell T, Litt Brian, Hariharan Hari, Elliott Mark A, Detre John A, Reddy Ravinder: Glutamate imaging (GluCEST) lateralizes epileptic foci in nonlesional temporal lobe epilepsy. Science translational medicine 7(309): 309ra161, Oct 2015.

Chen H Isaac, Bohman Leif-Erik, Emery Lyndsey, Martinez-Lage Maria, Richardson Andrew G, Davis Kathryn A, Pollard John R, Litt Brian, Gausas Roberta E, Lucas Timothy H: Lateral Transorbital Endoscopic Access to the Hippocampus, Amygdala, and Entorhinal Cortex: Initial Clinical Experience. ORL; journal for oto-rhino-laryngology and its related specialties 77(6): 321-332, Sep 2015.

Abdullah Kalil G, Attiah Mark A, Olsen Andrew S, Richardson Andrew, Lucas Timothy H: Reducing surgical site infections following craniotomy: examination of the use of topical vancomycin. Journal of neurosurgery Page: 1-5, Jun 2015.

Liu Xilin, Zhang Milin, Subei Basheer, Richardson Andrew G, Lucas Timothy H, Van der Spiegel Jan: The PennBMBI: Design of a General Purpose Wireless Brain-Machine-Brain Interface System. IEEE transactions on biomedical circuits and systems 9(2): 248-58, Apr 2015.

Azarion Allan A, Wu Jue, Pearce Allison, Krish Veena T, Wagenaar Joost, Chen Weixuan, Zheng Yuanjie, Wang Hongzhi, Lucas Timothy H, Litt Brian, Gee James C, Davis Kathryn A: An open-source automated platform for three-dimensional visualization of subdural electrodes using CT-MRI coregistration. Epilepsia 55(12): 2028-37, Dec 2014.

Wu J, A Azarion, A Pearce, VT Krish, J Waagener, W Chen, Y Zheng, WH Zhi, TH Lucas, J Gee, B Litt and K Davis: An open-source, automated platform for visualizing subdural electrodes using 3D CT-MRI co-registration. Epilepsia Nov 2014 Notes: Epub Ahead of Print

Chen H Isaac, Attiah Mark, Baltuch Gordon, Smith Douglas H, Hamilton Roy H, Lucas Timothy H: Harnessing plasticity for the treatment of neurosurgical disorders: an overview. World neurosurgery 82(5): 648-59, Nov 2014.

Kuzum D, H Takano, E Shim, JC Reed, H Juul, AG Richardson, J deVries, H Bink, MA Dichter, TH Lucas, DA Coulter, E Cubukeu and B Litt: Transparent, flexible, low-noise graphene electrodes for simultaneous electrophysiology and neuro-imaging. Nature Communications 5(5259), Oct 2014 Notes: Internet-Only Publication; DOI: 10.1038/ncommons6259

Geller Aaron S, Burke John F, Sperling Michael R, Sharan Ashwini D, Litt Brian, Baltuch Gordon H, Lucas Timothy H, Kahana Michael J: Eye closure causes widespread low-frequency power increase and focal gamma attenuation in the human electrocorticogram. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 125(9): 1764-73, Sep 2014.

Burke J, A Sharan, J Evans, K Healey, E Beck, K Davis, T Lucas and M Kahana: Theta and high-frequency mark spontaneous recall of episodic memories. Journal of Neuroscience 34(34): 11355-11365, Aug 2014.

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Last updated: 10/16/2015
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