Timothy H Lucas Jr., M.D., Ph.D., M.H.C.I.
3rd Floor Silverstein
Philadelphia, PA 19104
B.S. (Neurobiological Sciences & Psychobiology)
University of Florida, 1996.
University of Florida, 2001.
Ph.D. (Physiology & Biophysics)
University of Washington, 2009.
M.H.C.I. (Health Care Innovation, Health Policy Dept & Wharton)
University of Pennsylvania, 2019.
Research Fellow, Medical Neuroscience, National Institutes of Health, 1995-1995.
Research Fellow, American Heart Association, 1998-1998.
Intern in General Surgery, University of Washington, 2001-2002.
Resident in Neurological Surgery, University of Washington, 2002-2009.
Specialist Registrar in Neurological Surgery, St. George's National Healthcare Trust, London, England, UK, 2006-2007.
Chief Resident in Neurological Surgery, University of Washington, 2009-2010.
Fellow in Neurosurgical Oncology & Cerebrovascular Neurosurgery, University of Washington, 2010-2010.
Fellow in Neurosurgical Oncology Brain Mapping, University of California San Francisco, 2011-2011.
Fellow in Stereotactic & Functional Neurosurgery, University of California San Francisco, 2011-2011.
American Board of Neurological Surgery, 2016.
Description of Clinical ExpertiseEpilepsy Surgery
Minimally invasive neurosurgery
Cortisectomy / Topectomy
Corpus Callostomy / Functional Disconnection Surgery
Stereotactic and Functional Neurosurgery
Movement Disorder Surgery (Parkinson's Disease, Essential Tremor, Dystonia)
Glioma Surgery (Low Grade, High Grade, Adult, Pediatric)
Brain Mapping (Speech, Motor, Sensory; cortical and subcortical)
Extraoperative Brain Mapping
Brain-machine interface / Brain-computer interface
Skull base surgery
Eloquent Cortex Lesions (motor, sensory, speech, visual cortex)
Traumatic brain and spine injury
Description of Research ExpertiseBrain-machine interface / Brain-computer interface
Motor Cortex Functional Organization
Speech and Language Organization
Basal Ganglia - Cortical Interactions
Cortical/Basal Ganglia Stimulation
Cortical Spike and Local Field Recording
Basal Ganglia Spike and Local Field Recording
Spinal Cord Stimulation and Mapping
Selected PublicationsRichardson, AG, Y Ghenbot, X Liu, H Has, C Rinehart, S DeLuccia, ST Maldonado, G Boyek, M Zhang, F Aflatouni, J Van der Spiegel, TH Lucas: Learning active sensing strategies using a sensory brain-machine interface. PNAS 116(35): 17509-14, August 2019.
Kini, LG, JM Bernabei, F Mikhail, P Hadar, P Shah, AN Khambhati, K Oechsel, R Archer, J Boccanfuso, E Conrad, RT Shinohara, J Stein, S Das, A Kheder, TH Lucas, KA Davis, DS Bassett, B Litt: Virtual resection predicts surgical outcome for drug resistant epilepsy. Brain 142(12): 3892-3905, October 2019.
Khambhati AN, AE Kahn, J Costantini, Y Ezzyat, E Solomon, RE Gross, BC Jobst, SA Sheth, KA Zaghloul, G Worrell, S Seger, BC Lega, S Weiss, MR Sperling, R Gorniak, SR Das, JM Stein, DS Rizzuto, MJ Kahana, TH Lucas, KA Davis, JI Tracey, BS Bassett. : Functional control of electrophysiological network architecture using direct neurostimulation in humans. Network Neuroscience, MIT Press 3(3): 848-877, April 2019.
Jacob F, R Salinas, D Zhang, P Nguyen, GL Ming, D Petrov, TH Lucas, HI Chen, D O'Rourke, Song H: A patient-derived glioblastoma organoid model and biobank recapitulates inter- and intra-tumor heterogeneity. Cell 180(1): 188-204, January 2020.
Shah P, JM Bernadbei, L Kini, A Ashourvan, J Boccanfuso, R Archer, K Oechsel, SR Das, JM Stein, TH Lucas, DS Bassett, KA Davis and B Litt: High intertidal connectivity within the resection zone is associated with favorable post-surgical outcomes in focal epilepsy patients. NeuroImage 23: 101908-19, December 2019.
Stiso, J, AN Khambhati, T Mernara, AE Kahn, J Stein, SR Das, R Gorniak, J Tracy, B Litt, KA Davis, F Pasqualetti, TH Lucas, DS Bassett: White matter network architecture guides direct electrical stimulation through optimal state transitions. Cell Reports 28(10): 2554-66, September 2019.
Vitale F, M Allen, K Cullen, AG Richardson, TH Lucas, B Litt: Biomimetic extracellular matrix coatings improve the chronic biocompatibility of microfabricated subdural microelectrode arrays. PLoS One 13(11): e0206137, Nov 2018.
Driscoll N, AG Richardson, K Maleski, B Anasori, O Adewole, P Lelyukh, L Escobedo, K Cullen , TH Lucas, Y Gogotsi, F Vitale: Two-Dimensional TiC MXene for High-Resolution Neural Interfaces. ACS Nano: Journal of American Chemical Society 12(10): 10419-10429, Oct 2018.
Gourmaud S, H Shou, DJ Irwin, K Sansalone, L Jacobs, TH Lucas, ED Marsh, KA Davis, FE Jensen, DM Talos: Alzheimer's like amyloid and tau pathology associated with cognitive deficit in temporal lobe epilepsy. Brain 143(1): 191-209, December 2019.
Agarwal Prateek, Abdullah Kalil G, Ramayya Ashwin G, Nayak Nikhil R, Lucas Timothy H: A Retrospective Propensity Score-Matched Early Thromboembolic Event Analysis of Prothrombin Complex Concentrate vs Fresh Frozen Plasma for Warfarin Reversal Prior to Emergency Neurosurgical Procedures. Neurosurgery 82(6): 877-886, Jun 2018.