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Timothy H Lucas Jr., M.D., Ph.D.

Assistant Professor of Neurosurgery
Attending Neurosurgeon, Pennsylvania Hospital
Director, Translational Neuromodulation Laboratory, Department of Neurosurgery, University of Pennsylvania
Associate Director, Center for Neuroengineering & Therapeutics, University of Pennsylvania
Attending Neurosurgeon , Penn Presbyterian Medical Center
Attending Neurosurgeon, Children's Hospital of Philadelphia
Surgical Director, Penn Epilepsy Center, The Hospital of the University of Pennsylvania
Director, Neurosurgery Gene Therapy Program, Perelman School of Medicine, School of Engineering & Applied Science (SEAS), University of Pennsylvania
Director, Laser Neurosurgery Center, Perelman School of Medicine, University of Pennsylvania
Mack Technology Fellow, Wharton Business School, University of Pennsylvania
Department: Neurosurgery

Contact information
3400 Spruce Street
3rd Floor Silverstein
Philadelphia, PA 19104
Office: 215-615-0578
Fax: 215-349-5534
Lab: 215-746-1336
Graduate Group Affiliations
B.S. (Neurobiological Sciences & Psychobiology)
University of Florida, 1996.
M.D. (Medicine)
University of Florida, 2001.
Ph.D. (Physiology & Biophysics)
University of Washington, 2009.
MHCI (Health Care Innovation, Health Policy Dept & Wharton)
University of Pennsylvania, 2019.
Post-Graduate Training
Intern in General Surgery, University of Washington, 2001-2002.
Resident in Neurological Surgery, University of Washington, 2002-2009.
Specialist Registrar in Neurological Surgery, St. George's National Healthcare Trust, London, England, UK, 2006-2007.
Chief Resident in Neurological Surgery, University of Washington, 2009-2010.
Fellow in Neurosurgical Oncology & Cerebrovascular Neurosurgery, University of Washington, 2010-2010.
Fellow in Stereotactic & Functional Neurosurgery, University of California San Francisco, 2011-2011.
Fellow in Neurosurgical Oncology Brain Mapping, University of California San Francisco, 2011-2011.
American Board of Neurological Surgery, 2016.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Description of Clinical Expertise

Epilepsy Surgery
Temporal Lobectomy
Minimally invasive neurosurgery
Laser Neurosurgery
Endoscopic Surgery
Sports Neurosurgery
Cortisectomy / Topectomy
Corpus Callostomy / Functional Disconnection Surgery
Trigeminal neuralgia
Microvascular decompression
Stereotactic and Functional Neurosurgery
Movement Disorder Surgery (Parkinson's Disease, Essential Tremor, Dystonia)
Glioma Surgery (Low Grade, High Grade, Adult, Pediatric)
Insular Lesions
Brain Mapping (Speech, Motor, Sensory; cortical and subcortical)
Extraoperative Brain Mapping
Brain-machine interface / Brain-computer interface
Spine Disorders
Spinal Fusion
Skull base surgery
Brain Plasticity
Eloquent Cortex Lesions (motor, sensory, speech, visual cortex)
Traumatic brain and spine injury

Description of Research Expertise

Brain-machine interface / Brain-computer interface
Motor Cortex Functional Organization
Voluntary Movement
Speech and Language Organization
Cortical Plasticity
Basal Ganglia - Cortical Interactions
Cortical/Basal Ganglia Stimulation
Cortical Spike and Local Field Recording
Basal Ganglia Spike and Local Field Recording
Spinal Cord Stimulation and Mapping

Selected Publications

Ghenbot Y, A Richardson, X Liu, H Hao, S DeLuccia, G Boyek, J Van der Spiegel, TH Lucas: "Augmenting perception through electrical stimulation of adult somatosensory cortex" Association for Clinical and Translational Science, Annual Meeting, Washington D.C. 2018 Notes: Poster Presentation.

Chen H and TH Lucas: Advances in DBS surgery. Advances in Functional Neurosurgery, Thieme. Anderson, W (eds.). Thieme, 1(1), 6 2018.

Goel N, AN Mallela, P Agarwal, KG Abdulla, OA Choudhri, DK Kung, TH Lucas, HI Chen: Complications predicting perioperative mortality in patients undergoing elective craniotomy: A population based study. World Neurosurgery 118: 195-205, 2018.

Buch V, C Brandon, A Khambhati, A Richardson, BS Bassett, TH Lucas: "Increased dynamic modularity of the fronto-temporo-limbic network precedes enhanced task performance". American Association of Neurological Surgeons Annual Meeting, New Orleans 2018 Notes: Poster Presentation.

Talos DM, LM Jacobs, S Gourmaud, C Coto, H Sun, K Lim, TH Lucas, KA Davis, M Martinez-Lage, FE Jensen: Activation of mechanistic target of rapamycin complex 1 and 2 in human temporal lobe epilepsy. Annals of Neurology 83: 311-327, 2018.

Buch V, AG Richardson and TH Lucas: Network brain-computer interface (nBCI): An alternative approach for cognitive prosthetics. Frontiers in Neuroscience 2018.

Hitti F, P Gonzalez-Alegre, TH Lucas: Gene therapy for neurological disease. World Neurosurgery 2018.

Driscoll, N, AG Richardson, K Maleski, B Anasori, O Adewole, P Lelyukh, L Escobedo, B Murphy, DK Cullen, TH Lucas, Y Gogotsi, F Vitale: Two-dimensional Ti3C2 MXene for high-resolution neural interfaces. ACS Nano 2018.

Stiso, J, AN Khambhati, T Mernara, AE Kahn, J Stein, SR Das, R Gorniak, J Tracy, B Litt, KA Davis, F Pasqualetti, TH Lucas, DS Bassett: White matter network architecture guides direct electrical stimulation through optimal state transitions. BioRxiv 2018.

Goel N, K Abdullah, O Choudhri, D Kung, T Lucas, HI Chen: The effect of underlying liver disease on perioperative outcomes following craniotomy for tumor: an American College of Surgeons-National Quality Improvement Program Analysis. World Neurosurgery 115: 85-96, 2018.

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Last updated: 10/24/2018
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