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Timothy H Lucas Jr., M.D., Ph.D.

Assistant Professor of Neurosurgery
Director, Translational Neuromodulation Laboratory, Department of Neurosurgery, University of Pennsylvania
Associate Director, Center for Neuroengineering & Therapeutics, University of Pennsylvania
Department: Neurosurgery

Contact information
3400 Spruce Street
3rd Floor Silverstein
Philadelphia, PA 19104
Office: 215-615-0578
Fax: 215-349-5534
Lab: 215-746-1336
Graduate Group Affiliations
B.S. (Neurobiological Sciences & Psychobiology)
University of Florida, 1996.
M.D. (Medicine)
University of Florida, 2001.
Ph.D. (Physiology & Biophysics)
University of Washington, 2009.
Post-Graduate Training
Intern in General Surgery, University of Washington, 2001-2002.
Resident in Neurological Surgery, University of Washington, 2002-2009.
Specialist Registrar in Neurological Surgery, St. George's National Healthcare Trust, London, England, UK, 2006-2007.
Chief Resident in Neurological Surgery, University of Washington, 2009-2010.
Fellow in Neurosurgical Oncology & Cerebrovascular Neurosurgery, University of Washington, 2010-2010.
Clinical Experience in Stereotactic & Functional Neurosurgery, University of California San Francisco, 2011-2011.
Fellow in Neurosurgical Oncology Brain Mapping, University of California San Francisco, 2011-2011.
American Board of Neurological Surgeons (Board Eligible), 2011.
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Description of Clinical Expertise

Epilepsy Surgery
Temporal Lobectomy
Minimally invasive neurosurgery
Laser Neurosurgery
Endoscopic Surgery
Sports Neurosurgery
Cortisectomy / Topectomy
Corpus Callostomy / Functional Disconnection Surgery
Trigeminal neuralgia
Microvascular decompression
Stereotactic and Functional Neurosurgery
Movement Disorder Surgery (Parkinson's Disease, Essential Tremor, Dystonia)
Glioma Surgery (Low Grade, High Grade, Adult, Pediatric)
Insular Lesions
Brain Mapping (Speech, Motor, Sensory; cortical and subcortical)
Extraoperative Brain Mapping
Brain-machine interface / Brain-computer interface
Spine Disorders
Spinal Fusion
Skull base surgery
Brain Plasticity
Eloquent Cortex Lesions (motor, sensory, speech, visual cortex)
Traumatic brain and spine injury

Description of Research Expertise

Brain-machine interface / Brain-computer interface
Motor Cortex Functional Organization
Voluntary Movement
Speech and Language Organization
Cortical Plasticity
Basal Ganglia - Cortical Interactions
Cortical/Basal Ganglia Stimulation
Cortical Spike and Local Field Recording
Basal Ganglia Spike and Local Field Recording
Spinal Cord Stimulation and Mapping

Selected Publications

Wu J, A Azarion, A Pearce, VT Krish, J Waagener, W Chen, Y Zheng, WH Zhi, TH Lucas, J Gee, B Litt and K Davis: An open-source, automated platform for visualizing subdural electrodes using 3D CT-MRI co-registration. Epilepsia Nov 2014 Notes: Epub Ahead of Print

Kuzum D, H Takano, E Shim, JC Reed, H Juul, AG Richardson, J deVries, H Bink, MA Dichter, TH Lucas, DA Coulter, E Cubukeu and B Litt: Transparent, flexible, low-noise graphene electrodes for simultaneous electrophysiology and neuro-imaging. Nature Communications 5(5259), Oct 2014 Notes: Internet-Only Publication; DOI: 10.1038/ncommons6259

Burke J, A Sharan, J Evans, K Healey, E Beck, K Davis, T Lucas and M Kahana: Theta and high-frequency mark spontaneous recall of episodic memories. Journal of Neuroscience 34(34): 11355-11365, Aug 2014.

Chen HI, LE Bohman, L Loevener and TH Lucas: Trans-orbital endoscopic amygdalo-hippocampectomy. Journal of Neurosurgery 120(6): 1428-1436, Jun 2014.

Geller AS, JF Burke, MR Sperling, AD Sharan, B Litt, GH Baultuch, TH Lucas and MJ Kahana: Eye closure causes widespread low-frequency power increase and focal gamma attenuation in human electrocorticogram. Clinical Neurophysiology 125(9): 1764-73, 2014.

Liu X, M Zhang, AG Richardson, TH Lucas and J Van der Spiegel: The PennBMBI: A general purpose wireless brain-machine-brain interface system in unrestrained animals IEEE Circuits and Systems Page: 650-630, 2014 Notes: Internet-Only Publication; No DOI.

Lucas Timothy H, Fetz Eberhard E: Myo-cortical crossed feedback reorganizes primate motor cortex output. The Journal of neuroscience: The official journal of the Society for Neuroscience 33(12): 5261-74, Mar 2013.

Lucas, T. H., Ellenbogen, R. G.: Approaches to the Ventricular Tumors. Neurosurgery Quarterly 21(1): 50-9, 2011.

Lucas, T. H., Drane, D. L., Dodrill, C. B., Ojemann, G. A.: Speech localization in patients with preoperative language deficits: A stimulation mapping investigation. Neurosurgery 63(3): 487-497, 2008.

Moritz, C. T., Lucas, T. H., Perlmutter, S. I., Fetz, E. E.: Forelimb movements and muscle responses evoked by microstimulation of cervical spinal cord in sedated monkeys. J Neurophysiol 97(1): 110-20, 2007.

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Last updated: 12/23/2014
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