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Felix Werner Wehrli, PhD

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Professor of Radiologic Science in Radiology
Member, Committee for Appointments and Promotions, Department of Radiology, University of Pennsylvania Medical Center
Director, Laboratory for Structural, Physiologic and Functional Imaging, University of Pennsylvania Medical Center
Member, Research Executive Committee, Department of Radiology, University of Pennsylvania Medical Center
Department: Radiology

Contact information
University of Pennsylvania
Perelman School of Medicine
Department of Radiology
MRI Education Center
First Floor Founders Building
3400 Spruce Street
Philadelphia, PA 19104-4283
Office: (215) 662-7951
Fax: (215) 662-7263
Lab: (215) 349-8519
Graduate Group Affiliations
MS (Chemistry)
Swiss Federal Institute of Technology , 1967.
PhD (Chemistry)
Swiss Federal Institute of Technology, 1968.
Post-Graduate Training
Postdoctoral Research in Chemistry, Swiss Federal Institute of Technology, 1968-1970.
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Description of Research Expertise

Research of the Laboratory for Structural, Physiologic and Functional Imaging is aimed at quantitatively characterizing tissue microarchitecture and its relationship to physiology and function by means of spatially resolved nuclear magnetic resonance in animals and humans.

A major focus of the Laboratory is the development of new methods for the quantitative assessment of metabolic bone disease by means of the MR-based "virtual bone biopsy" and image-based computational biomechanics. A related area of concentration is the reduction to practice and translation to the clinic of novel quantitative solid-state proton and phosphorus MRI techniques for the study of bone matrix and mineral properties. A further line of work focuses on the quantification of systemic vascular disease via functional MRI-based methods including time-resolved blood flow, vascular compliance and venous blood oximetry with applications to the peripheral and central vascular system

Other areas of active in-house and collaborative research comprise the further development of novel non-Cartesian imaging techniques for cancer staging in the abdomen and chest, research aimed at the study of gene expression in mouse models of disease using novel micro-CT approaches, the study of neuronal architecture in mouse models of spinal cord injury by means of diffusion diffraction NMR, the development of MRI techniques to map internal strains of the intervertebral disc, and the development of novel RF coil hardware for ultra-high field MRI. Investigators in the lab have also recently embarked on a program aimed to develop and implement methods for imaging with real-time feedback control applied to fMRI of drug addiction and treatment.

Selected Publications

Zhao X, Lee H, Song HK, Cheng C-C, Wehrli FW: Impact of gradient imperfections on bone water quantification with UTE MRI. Magnetic Resonance in Medicine 84(4): 2034-2047, Oct 2020.

Lee H, Zhao X, Song HK, Wehrli FW: Venous cerebral blood volume mapping in the whole brain using venous-spin-labeled 3D turbo-spin-echo. Magnetic Resonance in Medicine 39(9): 1991-2003, Oct 2020.

Lee H, Zhao X, Song HK, Wehrli FW: Self-Navigated Three-dimensional ultrashort echo time technique for motion-corrected skull MRI. IEEE Transactions in Medical Imaging 39(9): 2869-2880, Sept 2020.

Eliav U, Wehrli FW, Navon G: New insight into the organization of myelin water using deuterium NMR. Magnetic Resonance in Medicine 84(2): 535-541, Aug 2020.

Englund EK, Fernandez-Seara MA, Rodriguez-Soto AC, Lee H, Rodgers ZB, Vidorreta M, Detre JA, Wehrl FW: Calibrated fMRI for dynamic mapping of CMRO2 responses using MR-based measurements of whole-brain venous oxygen saturation. Journal of Cerebral Blood Flow and Metabolism 40(7): 1501-1516, July 2020.

Wu P-H, Rodriguez-Soto AE, Rodgers ZB, England EK, Wiemken A, Langham MC, Detre JA, Schwab RJ, Guo W, Wehrli FW: MRI evaluation of cerebrovascular reactivity in obstructive sleep apnea. Journal of Cerebral Blood Flow and Metabolism 40(6): 1328-1337, Jun 2020.

Wehrli FW, Caporale A, Langham MC, Chatterjee S: New insights from MRI and cell biology into the acute vascular-metabolic implications of electronic cigarette vaping. Frontiers in Physiology 11: 492, May 2020.

Moon B, Iyer SK, Hwang E, Imai A, Okamoto K, Saito Y, Pilla J, Gorman J, Gorman R, Tschabrunn C, Keeney S, Castillero E, Jockusch S, Wehrli FW, Ferrari G, Zhou H, Ferrari V, Han Y, Aanti Gulhane A, Litt H, Matthai W, Witschey W: Iron imaging in myocardial infarction reperfusion injury. Nature Communications 11: 3273, 2020.

Zhang R, Lee H, Zhao X, Song HK, Vossough A, Wehrli FW, Bartlett SP: Bone-selective MRI as a nonradiative alternative to CT for craniofacial imaging. Academic Radiology Online ahead of print 2020.

Derakhshan JJ, Parvin N, Loevner LA, Wehrli FW, McKinstry RC: Effects of motion and b-value on apparent temperature measurement by diffusion-based thermometry MRI: eye vitreous study. Medical Physics Online ahead of print 2020.

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Last updated: 09/08/2020
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