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Felix W. Wehrli, Ph.D.

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Professor of Radiologic Science in Radiology
Member, Committee for Appointments and Promotions, Department of Radiology, University of Pennsylvania Medical Center
Director, Laboratory for Structural, Physiologic and Functional Imaging, University of Pennsylvania Medical Center
Member, Research Committee, Department of Radiology, University of Pennsylvania Medical Center
Department: Radiology

Contact information
University of Pennsylvania Perelman School of Medicine
Department of Radiology
1 Founders Building, 3400 Spruce Street
Philadelphia, PA 19104
Office: (215) 662-7951
Fax: (215) 662-7263
Lab: (215) 349-8519
Graduate Group Affiliations
M.S. (Chemistry)
Swiss Federal Institute of Technology , 1967.
Ph.D. (Chemistry)
Swiss Federal Institute of Technology, 1968.
Post-Graduate Training
Postdoctoral Research in Chemistry, Swiss Federal Institute of Technology, 1968-1970.
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Description of Research Expertise

Research of the Laboratory for Structural, Physiologic and Functional Imaging is aimed at quantitatively characterizing tissue microarchitecture and its relationship to physiology and function by means of spatially resolved nuclear magnetic resonance in animals and humans.

A major focus of the Laboratory is the development of new methods for the quantitative assessment of metabolic bone disease by means of the MR-based "virtual bone biopsy" and image-based computational biomechanics. A related area of concentration is the reduction to practice and translation to the clinic of novel quantitative solid-state proton and phosphorus MRI techniques for the study of bone matrix and mineral properties. A further line of work focuses on the quantification of systemic vascular disease via functional MRI-based methods including time-resolved blood flow, vascular compliance and venous blood oximetry with applications to the peripheral and central vascular system

Other areas of active in-house and collaborative research comprise the further development of novel non-Cartesian imaging techniques for cancer staging in the abdomen and chest, research aimed at the study of gene expression in mouse models of disease using novel micro-CT approaches, the study of neuronal architecture in mouse models of spinal cord injury by means of diffusion diffraction NMR, the development of MRI techniques to map internal strains of the intervertebral disc, and the development of novel RF coil hardware for ultra-high field MRI. Investigators in the lab have also recently embarked on a program aimed to develop and implement methods for imaging with real-time feedback control applied to fMRI of drug addiction and treatment.

Selected Publications

Langham MC, Rodriguez-Soto AE, Schwartz N, Wehrli FW. : In vivo whole-blood T2 versus HbO2 calibration by modulating blood oxygenation level in the femoral vein through intermittent cuff occlusion. Magnetic Resonance in Medicine 79(4): 2290–2296, 2018.

Cao W, Chang YV, Englund EK, Song HK, Barhoum S, Rodgers ZB, Langham MC, Wehrli FW. : High-speed whole-brain oximetry by golden-angle radial MRI. Magnetic Resonance in Medicine 79(1): 217-223, 2018.

Zhao X, Song HK, Wehrli FW: In vivo bone 31P relaxation times and their implications on mineral quantification. Magnetic Resonance in Medicine [Epub ahead of print], 2018.

Rajapakse CS, Kobe EA, Batzdorf AS, Hast MW, Wehrli FW: Accuracy of MRI-based finite element assessment of distal tibia compared to mechanical testing. Bone 108: 71-78, 2018.

Derakhshan JJ, McDonald Es, Siegelman ES, Schnall MD, Wehrli FW. : Characterizing and eliminating errors in enhancement and subtraction artifacts in dynamic contrast-enhanced breast MRI: chemical shift artifact of the third kind. Magnetic Resonance in Medicine 79(4): 2277-2289, 2018.

Rodriguez-Soto, AE, Abdulmalik O, Langham MC, Schwartz N, Lee H, Wehrli FW. : T2-prepared balanced steady-state free precession (bSSFP) for quantifying whole-blood oxygen saturation at 1.5T. Magnetic Resonance in Medicine 79(4): 1893–1900, 2018.

Englund EK, Rodgers ZB, Langham MC, Mohler ER 3rd, Floyd TF, Wehrli FW.: Simultaneous measurement of macro- and microvascular blood flow and oxygen saturation for quantification of muscle oxygen consumption. Magnetic Resonance in Medicine 79(2): 846-855, 2018.

Lee H, Englund EK, Wehrli FW. : Interleaved quantitative BOLD: combining extravascular R2'- and Intravascular R2-Measurements for Estimation of Deoxygenated Blood Volume and Hemoglobin Oxygen Saturation. NeuroImage 174: 420-431, 2018.

Wehrli FW, Fan AP, Rodgers ZB, Englund EK, Langham MC.: Susceptibility-based time-resolved whole-organ and regional tissue oximetry. NMR in Biomedicine 30(4), Apr 2017.

Zhao X, Song HK, Seifert AC, Li C, Wehrli FW.: Feasibility of assessing bone matrix and mineral properties in vivo by combined solid-state 1H and 31P MRI. PLOS ONE Page: e0173995, Mar 2017.

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Last updated: 01/23/2020
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