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Hee Kwon Song, Ph.D.

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Associate Professor of Radiologic Science in Radiology
Committee Member, Center for Advanced Magnetic Resonance Imaging and Spectroscopy (CAMRIS)
Deputy Director LSNI, University of Pennsylvania
Institute for Translational Medicine and Therapeutics, University of Pennsylvania
Penn Center for Musculoskeletal Disorders, University of Pennsylvania
Department: Radiology

Contact information
1 Silverstein / MRI
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-662-6265
Fax: 215-662-7263
Education:
BS (Electrical Engineering)
Northwestern University, 1991.
MS (Bioengineering)
University of Pennsylvania, 1994.
PhD (Bioengineering)
University of Pennsylvania, 1999.
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Description of Research Expertise

Dr. Song is a biomedical engineer with a strong background in MRI physics and expertise in various areas of MRI engineering. Dr. Song has extensive experience in developing novel dynamic imaging strategies in MRI. For over a decade, his research has focused on the development of dynamic contrast-enhanced (DCE-) MRI strategies based on novel radial data acquisition and reconstruction methods that allow ultra-rapid dynamic imaging at both high spatial and high temporal resolutions. Utilizing the golden angle radial acquisition strategy, Dr. Song also developed and implemented effective strategies to retrospectively compensate for respiratory motion in DCE-MRI. The technique also permits the reconstruction of the dynamic series to be highly flexible, allowing many of the decisions regarding spatial/temporal resolution to be made retrospectively and optimally. These strategies are currently being utilized for the assessment of treatment effects in various tumors, including lung, liver, breast, kidney and ovarian/fallopian tube. The methods he has developed have also been utilized in other areas of research, including rapid non-contrast enhanced dynamic MRA and fast tissue T1 mapping. Dr. Song collaborates with clinicians in various departments within Penn’s School of Medicine and other institutions, including the Departments of Medicine, Obstetrics and Gynecology, Neurology, and Radiation Oncology. The scope of training under Dr. Song’s guidance includes understanding the various tumor perfusion models, MRI physics, MRI pulse sequence programming and image post-processing.

Selected Publications

Hyunyeol Lee, Xia Zhao, Hee Kwon Song, Scott P. Bartlett, Felix W. Wehrli: Self-Navigated Three-Dimensional Ultrashort Echo Time for Motion-Corrected Skull MRI. IEEE Transactions in Medical Imaging 39(9): 2869-2880, 2020 Notes: 10.1109/TMI.2020.2978405.

Xia Zhao, Hyunyeol Lee, Hee Kwon Song, C. C. Cheng, Felix W. Wehrli: Impact of gradient imperfections on bone water quantification with UTE MRI. Magnetic Resonance in Medicine 84(4): 2034-2047, 2020.

Rosaline Zhang, Hyunyeol Lee, Xia Zhao, Hee Kwon Song, A. Vassough, Felix W. Wehrli, Scott P. Bartlett: Bone-Selective MRI as a Nonradiative Alternative to CT for Craniofacial Imaging. Academic Radiology 2020 Notes: 2020 Apr 13;S1076-6332(20)30142-2. doi: 10.1016/j.acra.2020.03.001. Online ahead of print.

Hyunyeol Lee, Xia Zhao, Hee Kwon Song, Rosaline Zhang, Scott Bartlett, Felix W. Wehrli: Rapid Dual-RF, Dual-Echo, Three-Dimensional Ultrashort Echo Time Craniofacial Imaging: A Feasibility Study. Magnetic Resonance in Medicine 81(5): 3007-3016, 2019.

Xia Zhao, Hee Kwon Song, Felix W Wehrli: In vivo bone 31P relaxation times and their implications on mineral quantification. Magnetic Resonance in Medicine 2018 Notes: In press.

F. Cong, Y. Zhuo, S. Yu, X. Zhang, X. Miao, J. An, H. K. Song, D. J. J. Wang, L. Yan: Non-contrast Enhanced Time-Resolved 4-Dimensional Dynamic Intracranial MR Angiography at 7T: A Feasibility Study. Journal of Magnetic Resonance Imaging 48(1): 111-120, 2018.

Wen Cao, Yulin V Chang, Erin K Englund, Hee Kwon Song, Suliman Barhoum, Zachary B Rodgers, Michael C Langham, Felix W Wehrli: High-Speed Whole-Brain Oximetry Via Golden-Angle Radial MRI. Magnetic Resonance in Medicine 79(1): 217-223, 2018.

Ziwu Zhou, Fei Han, Songlin Yu, Dandan Yu, Stanislas Rapacchi, Hee Kwon Song, Danny JJ Wang, Peng Hu, Lirong Yan: Accelerated non-contrast enhanced 4-dimensional intracranial MR angiography using golden-angle stack-of-stars trajectory and compressed sensing with magnitude subtraction. Magnetic Resonance in Medicine 79(2): 867-878, 2018.

Xia Zhao, Hee Kwon Song, Alan C. Seifert, Cheng Li, Felix W. Wehrli: Feasibility of Assessing Bone Matrix and Mineral Properties In Vivo by Combined Solid-State 1H 3 and 31P MRI. PLOS ONE 12(3): e0173995, 2017.

Zhang Ning, Magland Jeremy F, Song Hee Kwon, Wehrli Felix W: Registration-based autofocusing technique for automatic correction of motion artifacts in time-series studies of high-resolution bone MRI. Journal of magnetic resonance imaging : JMRI 41(4): 954-63, Apr 2015.

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Last updated: 09/08/2020
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