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Joel M Stein, MD, PhD

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Assistant Professor of Radiology at the Hospital of the University of Pennsylvania
Neuroradiologist, Hospital of the University of Pennsylvania
Neuroradiologist, Penn Presbyterian Medical Center
Neuroradiologist, Pennsylvania Hospital
Faculty Member, Center for Neuroengineering and Therapeutics, University of Pennsylvania
Senior Fellow, Center for Practice Transformation, Department of Radiology, University of Pennsylvania Health System
Department: Radiology

Contact information
Hospital of the University of Pennsylvania
Department of Radiology
1 Silverstein Pavilion
3400 Spruce Street
Philadelphia, PA 19104
BS (Biology)
University of North Carolina at Chapel Hill, 1998.
PhD (Cell and Molecular Biology)
University of Pennsylvania, 2005.
MD (Medicine)
University of Pennsylvania, 2007.
Post-Graduate Training
Post-doctoral Fellow, Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, 2006-2007.
Intern, Internal Medicine, University of Pennsylvania Health System, 2007-2008.
Resident, Diagnostic Radiology, University of Pennsylvania Health System, 2008-2012.
Chief Resident, Diagnostic Radiology, University of Pennsylvania Health System, 2011-2012.
Fellow, Neuroradiology, University of Pennsylvania Health System, 2012-2014.
Certification, Diagnostic Radiology, American Board of Radiology, 2012.
Certificate of Additional Qualification in Neuroradiology, American Board of Radiology, 2014.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Description of Clinical Expertise

Neuroradiology, epilepsy and brain tumor imaging, functional imaging

Description of Other Expertise

Mobile web and iOS applications in education and quality improvement

Description of Research Expertise

Epilepsy imaging, low field MRI, molecular imaging, small animal imaging and disease models, learning and memory

Selected Publications

Arnold TC, Baldassano SN, Litt B, Stein JM: Simulated diagnostic performance of low-field MRI: Harnessing open-access datasets to evaluate novel devices. Magn Reson Imaging 87: 67-76, April 2022.

Arnold TC, Tu D, Okar SV, Nair G, By S, Kawatra KD, Robert-Fitzgerald TE, Desiderio LM, Schindler MK, Shinohara RT, Reich DS, Stein JM: Sensitivity of portable low-field magnetic resonance imaging for multiple sclerosis lesions. NeuroImage: Clinical 35: 103101, June 2022.

Keiser MS, Ranum PT, Yrigollen CM, Carrell EM, Smith GR, Muehlmatt AL, Chen YH, Stein JM, Wolf RL, Radaelli E, Lucas TH, Gonzalez-Alegre P, and Davidson BL : Toxicity after AAV delivery of RNAi expression constructs into nonhuman primate brain. Nature Medicine 27(11): 1982-1989, Nov 2021 Notes: DOI: 10.1038/s41591-021-01522-3.

Opheim G, van der Kolk A, Markenroth Bloch K, Colon AJ, Davis KA, Henry TR, Jansen JFA, Jones SE, Pan JW, Rössler K, Stein JM, Strandberg MC, Trattnig S, Van de Moortele PF, Vargas MI, Wang I, Bartolomei F, Bernasconi N, Bernasconi A, Bernhardt B, Björkman-Burtscher I, Cosottini M, Das SR, Hertz-Pannier L, Inati S, Jurkiewicz MT, Khan AR, Liang S, Ma RE, Mukundan S, Pardoe H, Pinborg LH, Polimeni JR, Ranjeva JP, Steijvers E, Stufflebeam S, Veersema TJ, Vignaud A, Voets N, Vulliemoz S, Wiggins CJ, Xue R, Guerrini R, Guye M: 7T epilepsy task force consensus recommendations on the use of 7T MRI in clinical practice. Neurology 96(7): 327-341, February 2021.

Goyal A, Miller J, Qasim SE, Watrous AJ, Zhang H, Stein JM, Inman CS, Gross RE, Willie JT, Lega B, Lin J-J, Sharan A, Wu C, Sperling MR, Sheth SA, McKhann GM, Smith EH, Schevon C, Jacobs J: Functionally distinct high and low theta oscillations in the human hippocampus. Nature Communications 11(1): 2469, May 2020 Notes: doi: 10.1038/s41467-020-15670-6.

Yushkevich PA, Pashchinskiy A, Oguz I, Mohan S, Schmitt JE, Stein JM, Zukić D, Vicory J, McCormick M, Yushkevich N, Schwartz N, Gao Y, Gerig G.: User-guided segmentation of multi-modality medical imaging datasets with ITK-SNAP. Neuroinformatics 17(1): 83-102, January 2019 Notes: doi: 10.1007/s12021-018-9385-x.

Salman E. Qasim SE, Miller J, Inman CS, Gross RE, Willie JT, Lega B, Lin J-J, Sharan A, Wu C, Sperling MR, Sheth SA, McKhann GM, Smith EH, Schevon C, Stein JM, Jacobs​ J.: Memory retrieval modulates spatial tuning of single neurons in the human entorhinal cortex. Nature Neuroscience 22(12): 2078-2086, November 2019 Notes: doi: 10.1038/s41593-019-0523-z.

Shah P, Bernabei JM, Kini L, Ashourvan A, Boccanfuso J, Archer R, Oechsel K, Das SR, Stein JM, Lucas TH, Bassett DS, Davis KA, Litt B: High interictal connectivity within the resection zone is associated with favorable post-surgical outcomes in focal epilepsy patients. NeuroImage: Clinical 23: 101908, June 2019 Notes: DOI: 10.1016/j.nicl.2019.101908.

Amirshaghaghi A, Yan L, Miller J, Daniel Y, Stein JM, Busch TM, Cheng Z, Tsourkas A: Chlorin e6-coated superparamagnetic iron oxide nanoparticle (SPION) nanoclusters as a theranostic agent for dual-mode imaging and photodynamic therapy. Scientific Reports 9(1): 2613, February 2019.

Shah P, Ashourvan A, Mikhail F, Pines A, Kini L, Oechsel K, Das SR, Stein JM, Shinohara RT, Bassett DS, Litt B, Davis KA: Characterizing the role of the structural connectome in seizure dynamics. Brain 142(7): 1955-1972, May 2019 Notes: doi: 10.1093/brain/awz125.

Shah P, Bassett DS, Wisse LEM, Detre JA, Stein JM, Yushkevich PA, Shinohara RT, Elliott MA, Das SR, Davis KA: Structural and functional asymmetry of medial temporal subregions in unilateral temporal lobe epilepsy: A 7T MRI study. Human Brain Mapping 40(8): 2390-2398, June 2019.

Ezzyat Y, Wanda PA, Levy DF, Kadel A, Aka A, Pedisich I, Sperling MR, Sharan AD, Lega BC, Burks A, Gross RE, Inman CS, Jobst BC, Gorenstein MA, Davis KA, Worrell GA, Kucewicz MT, Stein JM, Gorniak R, Das SR, Rizzuto DS, Kahana MJ: Closed-loop stimulation of temporal cortex rescues functional networks and improves memory. Nature Communications 9(1): 365, February 2018.

Solomon EA, Kragel JE, Gross R, Lega B, Sperling MR, Worrell G, Sheth SA, Zaghloul KA, Jobst BC, Stein JM, Das S, Gorniak R, Inman CS, Seger S, Rizzuto DS, Kahana MJ : Medial temporal lobe functional connectivity predicts stimulation-induced theta power. Nature Communications 9(1): 4437, October 2018 Notes: doi: 10.1038/s41467-018-06876-w.

Jacobs J, Miller J, Lee SA, Coffey T, Watrous AJ, Sperling MR, Sharan A, Worrell G, Berry B, Lega B, Jobst BC, Davis K, Gross RE, Sheth SA, Ezzyat Y, Das SR, Stein J, Gorniak R, Kahana MJ, Rizzuto DS.: Direct electrical stimulation of the human entorhinal region and hippocampus impairs memory. Neuron 92(5): 983-90, December 2016.

Schmitt JE and Stein JM: Radiographic Detection and Advanced Imaging of Glioblastoma. Glioblastoma, 1st Edition. Brem S and Abdullah KG (eds.). Elsevier, September 2016 Notes: ISBN: 9780323476607.

Stein, JM (Moderator): AJNR Fellows' Journal Club Podcast. American Journal of Neuroradiology January 2015 Notes:

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Last updated: 04/12/2023
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