Penn Medicine
Help | Search | Site Map | Contact   

Joel M Stein, MD, PhD

faculty photo
Assistant Professor of Radiology at the Hospital of the University of Pennsylvania
Neuroradiologist, Hospital of the University of Pennsylvania
Neuroradiologist, Penn Presbyterian Medical Center
Neuroradiologist, Pennsylvania Hospital
Senior Fellow, Center for Practice Transformation, Department of Radiology, University of Pennsylvania Health System
Department: Radiology

Contact information
Hospital of the University of Pennsylvania
Department of Radiology
1 Silverstein Pavilion
3400 Spruce Street
Philadelphia, PA 19104
BS (Biology)
University of North Carolina at Chapel Hill, 1998.
PhD (Cell and Molecular Biology)
University of Pennsylvania, 2005.
MD (Medicine)
University of Pennsylvania, 2007.
Post-Graduate Training
Post-doctoral Fellow, Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, 2006-2007.
Intern, Internal Medicine, University of Pennsylvania Health System, 2007-2008.
Resident, Diagnostic Radiology, University of Pennsylvania Health System, 2008-2012.
Chief Resident, Diagnostic Radiology, University of Pennsylvania Health System, 2011-2012.
Fellow, Neuroradiology, University of Pennsylvania Health System, 2012-2014.
Certification, Diagnostic Radiology, American Board of Radiology, 2012.
Certificate of Additional Qualification in Neuroradiology, American Board of Radiology, 2014.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Description of Clinical Expertise

Neuroradiology, epilepsy and brain tumor imaging, functional imaging, MRI, CT, image-guided lumbar puncture

Description of Other Expertise

Mobile web and iOS applications in education and quality improvement

Description of Research Expertise

Epilepsy imaging, molecular imaging, small animal imaging and disease models, learning and memory

Selected Publications

Salman E. Qasim SE, Miller J, Inman CS, Gross RE, Willie JT, Lega B, Lin J-J, Sharan A, Wu C, Sperling MR, Sheth SA, McKhann GM, Smith EH, Schevon C, Stein JM, Jacobs​ J.: Memory retrieval modulates spatial tuning of single neurons in the human entorhinal cortex. Nature Neuroscience 22(12): 2078-2086, November 2019 Notes: doi: 10.1038/s41593-019-0523-z.

Stiso J, Khambhati AN, Menara T, Kahn AE, Stein JM, Das SR, Gorniak R, Tracy J, Litt B, Davis KA, Pasqualetti F, Lucas T, Bassett DS: White matter network architecture guides direct electrical stimulation through optimal state transitions. Cell Reports 28(10): 2554-2566, September 2019 Notes: doi: 10.1016/j.celrep.2019.08.008.

Khambhati AN, Kahn AE, Costantini J, Ezzyat Y, Solomon EA, Gross RE, Jobst BC, Sheth SA, Zaghloul KA, Worrell G, Seger S, Lega BL, Weiss S, Sperling MR, Gorniak R, Das SR, Stein JM, Rizzuto DS, Kahana MJ, Lucas TH, Davis KA, Tracy JI, Bassett DS: Functional control of electrophysiological network architecture using direct neurostimulation in humans. Network Neuroscience 3(3): 848-877, July 2019 Notes: DOI: 10.1162/netn_a_00089.

Shah P, Bernabei JM, Kini L, Ashourvan A, Boccanfuso J, Archer R, Oechsel K, Das SR, Stein JM, Lucas TH, Bassett DS, Davis KA, Litt B: High interictal connectivity within the resection zone is associated with favorable post-surgical outcomes in focal epilepsy patients. NeuroImage: Clinical 23: 101908, June 2019 Notes: DOI: 10.1016/j.nicl.2019.101908.

Shah P, Bassett DS, Wisse LEM, Detre JA, Stein JM, Yushkevich PA, Shinohara RT, Elliott MA, Das SR, Davis KA: Structural and functional asymmetry of medial temporal subregions in unilateral temporal lobe epilepsy: A 7T MRI study. Human Brain Mapping 40(8): 2390-2398, June 2019.

Shah P, Ashourvan A, Mikhail F, Pines A, Kini L, Oechsel K, Das SR, Stein JM, Shinohara RT, Bassett DS, Litt B, Davis KA: Characterizing the role of the structural connectome in seizure dynamics. Brain 142(7): 1955-1972, May 2019 Notes: doi: 10.1093/brain/awz125.

Solomon EA, Stein JM, Das S, Gorniak R, Sperling MR, Worrell G, Inman CS, Tan RJ, Jobst BC, Rizzuto DS, Kahana MJ: Dynamic theta networks in the human medial temporal lobe support episodic memory. Current Biology 29(7): 1100-1111, April 2019 Notes: DOI: 10.1016/j.cub.2019.02.020.

Yushkevich PA, Pashchinskiy A, Oguz I, Mohan S, Schmitt JE, Stein JM, Zukić D, Vicory J, McCormick M, Yushkevich N, Schwartz N, Gao Y, Gerig G.: User-guided segmentation of multi-modality medical imaging datasets with ITK-SNAP. Neuroinformatics 17(1): 83-102, January 2019 Notes: doi: 10.1007/s12021-018-9385-x.

Amirshaghaghi A, Yan L, Miller J, Daniel Y, Stein JM, Busch TM, Cheng Z, Tsourkas A: Chlorin e6-coated superparamagnetic iron oxide nanoparticle (SPION) nanoclusters as a theranostic agent for dual-mode imaging and photodynamic therapy. Scientific Reports 9(1): 2613, February 2019.

Shah P, Bassett DS, Wisse LEM, Detre JA, Stein JM, Yushkevich PA, Shinohara RT, Pluta JB, Valenciano E, Daffner M, Wolk DA, Elliott MA, Litt B, Davis KA, Das SR: Mapping the structure and functional network architecture of the medial temporal lobe using 7T MRI. Human Brain Mapping 39(2): 851-865, February 2018 Notes: DOI: 10.1002/hbm.23887.

Solomon EA, Kragel JE, Gross R, Lega B, Sperling MR, Worrell G, Sheth SA, Zaghloul KA, Jobst BC, Stein JM, Das S, Gorniak R, Inman CS, Seger S, Rizzuto DS, Kahana MJ : Medial temporal lobe functional connectivity predicts stimulation-induced theta power. Nature Communications 9(1): 4437, October 2018 Notes: doi: 10.1038/s41467-018-06876-w.

Ezzyat Y, Wanda PA, Levy DF, Kadel A, Aka A, Pedisich I, Sperling MR, Sharan AD, Lega BC, Burks A, Gross RE, Inman CS, Jobst BC, Gorenstein MA, Davis KA, Worrell GA, Kucewicz MT, Stein JM, Gorniak R, Das SR, Rizzuto DS, Kahana MJ: Closed-loop stimulation of temporal cortex rescues functional networks and improves memory. Nature Communications 9(1): 365, February 2018.

Stein, JM (Moderator): AJNR Fellows' Journal Club Podcast. American Journal of Neuroradiology January 2015 Notes:

Schmitt JE and Stein JM: Radiographic Detection and Advanced Imaging of Glioblastoma. Glioblastoma, 1st Edition. Brem S and Abdullah KG (eds.). Elsevier, September 2016 Notes: ISBN: 9780323476607.

Jacobs J, Miller J, Lee SA, Coffey T, Watrous AJ, Sperling MR, Sharan A, Worrell G, Berry B, Lega B, Jobst BC, Davis K, Gross RE, Sheth SA, Ezzyat Y, Das SR, Stein J, Gorniak R, Kahana MJ, Rizzuto DS.: Direct electrical stimulation of the human entorhinal region and hippocampus impairs memory. Neuron 92(5): 983-90, December 2016.

back to top
Last updated: 02/02/2021
The Trustees of the University of Pennsylvania
© The Trustees of the University of Pennsylvania. Site best viewed with a supported browser.
SOM Home International Programs Penn Alumni Clinical Trials Centers and Institutes Departments Faculty Research Education Administration