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Paul A. Yushkevich, Ph.D.

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Professor of Radiology
Department: Radiology

Contact information
Penn Image Computing and Science Laboratory
Richards Building, 6th Floor, D605
3700 Hamilton Walk
Philadelphia, PA 19104
Office: 215-746-6924
B.S. (Computer Science and Mathematics)
University of North Carolina at Charlotte, 1996.
M.S. (Computer Science)
University of North Carolina Chapel Hill, 2000.
Ph.D. (Computer Science)
University of North Carolina Chapel Hill, 2003.
Post-Graduate Training
Research Fellow, Radiology, University of Pennsylvania, 2003-2006.
Permanent link
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Description of Research Expertise

My research portfolio combines theoretical work on statistical shape characterization using a symmetry-based representation of shape with applied and translational research in multiple areas of biomedical image analysis. I am particularly interested in analysis techniques that are tailored to specific anatomical structures. My key work in this area involves automatic segmentation and morphometry of the hippocampal formation (HF) in magnetic resonance imaging (MRI). The HF plays a central role in memory function and is a site of early neurodegeneration in Alzheimer’s disease. In a broad effort to develop more detailed imaging-based biomarkers for Alzheimer’s disease, my team has developed a first of its kind detailed computational atlas of the HF from postmortem MRI microscopy. With NIH R01 funding, we are now integrating this atlas with histology, leveraging it for the analysis of the HF and its subfields in in vivo MRI, and evaluating MRI-derived subfield-specific as alternative imaging biomarkers in dementia. We recently published a pioneering technique for automatic segmentation of HF subfields in high-resolution, HF-focused T2-weighted in vivo MRI, showing excellent agreement with manual segmentation. Concurrently, we developed and evaluated a strategy for improving the accuracy of general-purpose segmentation techniques using machine learning as a corrective wrapper method. Other recent publications include a surface-based tract-specific strategy for diffusion MRI analysis, for which open-source software is currently being developed, and an automatic cardiac MRI segmentation method with an explicit prior on heart wall thickness.

Selected Publications

Levack Melissa M, Mecozzi Gianclaudio, Jainandunsing Jayant S, Bouma Wobbe, Jassar Arminder S, Pouch Alison M, Yushkevich Paul A, Mariani Massimo A, Jackson Benjamin M, Gorman Joseph H, Gorman Robert C: Quantitative three-dimensional echocardiographic analysis of the bicuspid aortic valve and aortic root: A single modality approach. Journal of cardiac surgery 35(2): 375-382, Feb 2020.

Olsen Rosanna K, Carr Valerie A, Daugherty Ana M, La Joie Renaud, Amaral Robert S C, Amunts Katrin, Augustinack Jean C, Bakker Arnold, Bender Andrew R, Berron David, Boccardi Marina, Bocchetta Martina, Burggren Alison C, Chakravarty M Mallar, Chételat Gaël, de Flores Robin, DeKraker Jordan, Ding Song-Lin, Geerlings Mirjam I, Huang Yushan, Insausti Ricardo, Johnson Elliott G, Kanel Prabesh, Kedo Olga, Kennedy Kristen M, Keresztes Attila, Lee Joshua K, Lindenberger Ulman, Mueller Susanne G, Mulligan Elizabeth M, Ofen Noa, Palombo Daniela J, Pasquini Lorenzo, Pluta John, Raz Naftali, Rodrigue Karen M, Schlichting Margaret L, Lee Shing Yee, Stark Craig E L, Steve Trevor A, Suthana Nanthia A, Wang Lei, Werkle-Bergner Markus, Yushkevich Paul A, Yu Qijing, Wisse Laura E M: Progress update from the hippocampal subfields group. Alzheimer's & dementia (Amsterdam, Netherlands) 11: 439-449, Dec 2019.

de Flores Robin, Berron David, Ding Song-Lin, Ittyerah Ranjit, Pluta John B, Xie Long, Adler Daniel H, Robinson John L, Schuck Theresa, Trojanowski John Q, Grossman Murray, Liu Weixia, Pickup Stephen, Das Sandhitsu R, Wolk David A, Yushkevich Paul A, Wisse Laura E M: Characterization of hippocampal subfields using ex vivo MRI and histology data: Lessons for in vivo segmentation. Hippocampus Nov 2019.

Das Sandhitsu R, Xie Long, Wisse Laura E M, Vergnet Nicolas, Ittyerah Ranjit, Cui Salena, Yushkevich Paul A, Wolk David A: In vivo measures of tau burden are associated with atrophy in early Braak stage medial temporal lobe regions in amyloid-negative individuals. Alzheimer's & dementia : the journal of the Alzheimer's Association 15(10): 1286-1295, Sep 2019.

Xie Long, Wisse Laura E M, Pluta John, de Flores Robin, Piskin Virgine, Manjón Jose V, Wang Hongzhi, Das Sandhitsu R, Ding Song-Lin, Wolk David A, Yushkevich Paul A: Automated segmentation of medial temporal lobe subregions on in vivo T1-weighted MRI in early stages of Alzheimer's disease. Human brain mapping 40(12): 3431-3451, Aug 2019.

Delhaye Emma, Mechanic-Hamilton Dawn, Saad Laura, Das Sandhitsu R, Wisse Laura E M, Yushkevich Paul A, Wolk David A, Bastin Christine: Associative memory for conceptually unitized word pairs in mild cognitive impairment is related to the volume of the perirhinal cortex. Hippocampus 29(7): 630-638, Jul 2019.

Parivash Sherveen N, Goubran Maged, Mills Brian D, Rezaii Paymon, Thaler Christian, Wolman Dylan, Bian Wei, Mitchell Lex A, Boldt Brian, Douglas David, Wilson Eugene W, Choi Jay, Xie Long, Yushkevich Paul A, DiGiacomo Phil, Wongsripuemtet Jitsupa, Parekh Mansi, Fiehler Jens, Do Huy, Lopez Jaime, Rosenberg Jarrett, Camarillo David, Grant Gerald, Wintermark Max, Zeineh Michael: Longitudinal Changes in Hippocampal Subfield Volume Associated with Collegiate Football. Journal of neurotrauma 36(19): 2762-2773, Jun 2019.

Shah Preya, Bassett Danielle S, Wisse Laura E M, Detre John A, Stein Joel M, Yushkevich Paul A, Shinohara Russell T, Elliott Mark A, Das Sandhitsu R, Davis Kathryn A: Structural and functional asymmetry of medial temporal subregions in unilateral temporal lobe epilepsy: A 7T MRI study. Human brain mapping 40(8): 2390-2398, Jun 2019.

Xie Long, Das Sandhitsu R, Pilania Arun, Daffner Molly, Stockbower Grace E, Dolui Sudipto, Yushkevich Paul A, Detre John A, Wolk David A: Task-enhanced arterial spin labeled perfusion MRI predicts longitudinal neurodegeneration in mild cognitive impairment. Hippocampus 29(1): 26-36, Jan 2019.

Mueller Susanne G, Yushkevich Paul A, Das Sandhitsu, Wang Lei, Van Leemput Koen, Iglesias Juan Eugenio, Alpert Kate, Mezher Adam, Ng Peter, Paz Katrina, Weiner Michael W: Systematic comparison of different techniques to measure hippocampal subfield volumes in ADNI2. NeuroImage. Clinical 17(27): 1006-1018, Dec 2018.

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Last updated: 02/27/2020
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