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Bryan A Pukenas, MD

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Assistant Professor of Radiology at the Hospital of the University of Pennsylvania
Active, Penn Presbyterian Medical Center
Attending, Hospital of the University Pennsylvania
Active, Pennsylvania Hospital
Associate, Children's Hospital of Philadelphia
Attending, Virtua Health
Department: Radiology

Contact information
Hospital of the University of Pennsylvania
3400 Spruce Street, 219 Dulles
Philadelphia, PA 19104
Office: 215 662 6865
Fax: 215 662 3283
BA (Biology)
West Virginia University, 1999.
MD (Medicine)
West Virginia University School of Medicine, 2003.
Post-Graduate Training
Resident in Internal Medicine, Thomas Jefferson University Hospital, 2003-2004.
Resident in Diagnostic Radiology, Hospital of the University of Pennsylvania, 2004-2008.
Fellow in Diagnostic Neuroradiology, Hospital of the University of Pennsylvania, 2008-2009.
Fellow in Interventional Neuroradiology, Hospital of the University of Pennsylvania, 2009-2010.
Visiting Fellow in Interventional Neuroradiology, Johns Hopkins University, 2010-2010.
American Board of Radiology, 2008.
American Board of Radiology, Certificate of Added Qualification, Neuroradiology, 2014.
The Society of Neurological Surgeons Committee on Advanced Subspecialty Training, Neuro Endovascular Surgery, 2019.
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Description of Clinical Expertise

Interventional Neuroradiology (spinal and intracranial)
Arteriovenous Malformations
Arteriovenous Fistula
Carotid Stenosis
Intracranial Stenosis
Intracranial and spinal embolization
Interventional spinal pain management
Diagnostic Neuroradiology

Description of Research Expertise

Intracisternal gene therapy delivery
Suboccipital Puncture
Porcine Brain Injury
Canine intracranial vasospasm
Canine stroke
Radiation exposure to patients undergoing diagnostic radiology procedures
Vascular ultrasound
Contrast enhanced ultrasound for evaluation of brain tumors

Selected Publications

Zion Zibly, Yair Anikster, Shoshana Revel-Vilk, Ari Zimran, Mark Lowrey, Eriene A. Youssef, Jeffery Sevigny, Bryan Pukenas.: Safety of intracisternal administration of AAV9 based gene therapy: Case series of PR001 in infants with Gaucher disease type 2. WORLD Symposium San Diego, CA February 2021 Notes: ePresentation.

Bryan Pukenas, Mikhail Papisov, Nicholas Buss, Subha Karumuthil-Melethil, Anthony O'Berry, Kirsten Cowley, Marie-Laure Nevoret, Paulo Falabella: Intracisternal administration of AAV9 gene therapies to target the central nervous system. WORLD Symposium San Diego, CA February 2021.

Raymond Y. Wang, Tammam Beydoun, Nina Movsesyan, Shih-Hsin Kan, Mery Taylor, Winnie Stockton, Igor Nestrasil, Bryan Pukenas, Paulo Falabella, Yoonjin Cho, Marie-Laure Névoret.: First in-human intracisternal dosing of RGX-111 (adeno-associated virus 9/human α-L-iduronidase) for a 20-month-old child with mucopolysaccharidosis type I (MPS I): 1 year follow-up. WORLD Symposium San Diego, CA February 2021.

Karlsson M, Yang Z, Chawla S, Delso N, Pukenas B, Elmér E, Hugerth M, Margulies SS, Ehinger J, Hansson MJ, Wang KKW, Kilbaugh TJ.: Evaluation of Diffusion Tensor Imaging and Fluid Based Biomarkers in a Large Animal Trial of Cyclosporine in Focal Traumatic Brain Injury. J Neurotrauma Neurotrauma, January 2021.

Mattay RR, Shlansky-Goldberg R, Pukenas BA.: Recurrent massive hemoptysis in a patient with cystic fibrosis: balloon assisted Onyx embolization after bronchial artery coil recanalization. CVIR Endovasc 4: 4, Jan 2021.

Cox M, Rodriguez P, Mohan S, Sedora-Roman NI, Pukenas B, Choudhri O, Kurtz RM.: Tentorial Dural Arteriovenous Fistulas as a Cause of Thalamic Edema: 2 Cases of an Important Differential Diagnosis to Consider. Neurohospitalist 11: 33-39, Jan 2021.

Bryan A. Pukenas: Vascular Malformations. Decision-Making in Adult Neurology. Brett L. Cucchiara; Raymond S. Price (eds.). Elsevier, Inc. 2021.

Leker RR, Kasner SE, El Hasan HA, Sacagiu T, Honig A, Gomori JM, Guan S, Choudhry O, Hurst RW, Kung D, Pukenas B, Sedora-Roman N, Ramchand P, Cohen JE.: Impact of carotid tortuosity on outcome after endovascular thrombectomy. Neurol Sci eurol Sci, October 2020.

Lee Harrison T, Pukenas Bryan A, Sebro Ronnie: Change in Bone CT Attenuation and C-Reactive Protein are Predictors of Bone Biopsy Culture Positivity in Patients with Vertebral Discitis/Osteomyelitis. Spine (Phila Pa 1976) . 45(17): 1208-1214, September 2020 Notes: doi: 10.1097/BRS.0000000000003504.

Osama O Zaidat1, Ricardo A Hanel, Eric A Sauvageau, Amin Aghaebrahim, Eugene Lin, Ashutosh P Jadhav, Tudor G Jovin, Ahmad Khaldi, Rishi G Gupta, Andrew Johnson, Donald Frei, David Loy, Adel Malek, Gabor Toth, Adnan Siddiqui, John Reavey-Cantwell, Ajith Thomas, Steven W Hetts, Brian T Jankowitz, ATLAS Investigators: Pivotal Trial of the Neuroform Atlas Stent for Treatment of Anterior Circulation Aneurysms: One-Year Outcomes. Stroke 51(7): 2087-2094, July 2020 Notes: *Dr. Pukenas is an ATLAS Investigator doi: 10.1161/STROKEAHA.119.028418.

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Last updated: 04/29/2021
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