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Jacob Dubroff, MD, PhD

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Assistant Professor of Radiology at the Hospital of the University of Pennsylvania
Active Radiologist, Penn Presbyterian Medical Center
Active Radiologist, Pennsylvania Hospital
Attending Radiologist, Hospital of the University of Pennsylvania
Modality Chief, Nuclear Medicine and PET, Hospital of the University of Pennsylvania
Department: Radiology

Contact information
Hospital of the University of Pennsylvania
Department of Radiology
Division of Nuclear Imaging and Therapy
3400 Spruce Street
1 Silverstein
Philadelphia, PA 19104
Office: 215-662-3041
Fax: 215-349-5843
Graduate Group Affiliations
BAS (Biomedical Engineering)
University of Pennsylvania Philadelphia, PA, 1997.
BA (History and Sociology of Science)
University of Pennsylvania Philadelphia, PA, 1997.
PhD (Neuroscience)
SUNY Upstate Medical University Syracuse, NY, 2006.
MD (Medicine)
SUNY Upstate Medical University Syracuse, NY, 2006.
Post-Graduate Training
Intern, Transitional Year, Frankford Hospitals, Jefferson Health System , 2006-2007.
Resident, Nuclear Medicine, Hospital of the University of Pennsylvania, 2007-2009.
Chief Resident, Nuclear Medicine, Hospital of the University of Pennsylvania, 2009-2010.
United State Medical License Examination, 2007.
American Board of Nuclear Medicine, 2010.
Authorized User, Broad Scope License #PA-0131, PA, 2010.
ACLS (initial certification 2/2005), 2020.
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Description of Clinical Expertise

PET Brain Imaging of Dementia and Epilepsy
SPECT Brain Imaging of Parkinson's Disease
PET/CT Oncologic Imaging
PET Myocardial Imaging
Radionuclide Therapy
General Nuclear Medicine

Description of Other Expertise

Dr. Dubroff is clinician scientist who uses Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography to better understand the molecular mechanisms of drug abuse, including nicotine dependence and opioid use disorder, as well as neurodegenerative disease, including Parkinson's and Alzheimer's diseases. He collaborates with investigators in the Departments of Psychiatry and Neurology. His studies are supported by the National Institute of Drug Abuse (NIDA), the National Heart, Lung, and Blood Institute (NHLBI), the Michael J. Fox Foundation, and industry.

Description of Research Expertise

Neuroreceptor PET Imaging
Molecular Imaging of Neurological and Psychiatric Disease
Cardiac PET Imaging
Brain Plasticity

Selected Publications

Love T, Shabalin A, Kember R, Docherty A, Zhou H, Koppelmans V, Gelernter J, Baker A, Hartwell E, Dubroff J, and Zubieta JK: Unique and Joint Associations of Polygenic Risk for Major Depression and Opioid Use Disorder with Endogenous Opioid System Function. Neuropsychopharmacology. accepted (eds.). April 2022.

Aamodt WW, Dubroff JG, Cheng G, Taylor, Wood S, Duda JE, and Morley JF : Gait abnormalities and non-motor symptoms predict abnormal dopaminergic imaging in presumed drug-induced parkinsonism npj Parkinson's Disease March 2022 Notes: accepted.

Patterson KC, Rosenbach M, Bravo PE, Dubroff JG: Stable Extent of Recurrently Active Cardiac and Cutaneous Sarcoidosis. Front Med (Lausanne) 8(729229), December 2021 Notes: doi: 10.3389/fmed.2021.729229.

Phillips JS, Nitchie FJ, Da Re F, Olm CA, Cook PA, McMillan CT, Gee JC, Dubroff JG, Grossman M, Nasrallah IM: Rates of longitudinal change in 18F-flortaucipir PET vary by brain region, cognitive impairment, and age in atypical Alzheimer's disease. Alzheimer's & Dementia Sep 2021 Notes: doi: 10.1002/alz.12456. Online ahead of print.

Selvaraj S, Khan MS, Wiener PC, de Feria A, Rojulpote C, Julien H, Jacoby D, Litt H, Pryma D, Dubroff J, Guerraty MA, Bravo P: Incremental Prognostic Value of Visually Estimated Coronary Artery Calcium in Patients Undergoing Positron Emission Tomography Imaging. Open Heart 8(1), May 2021 Notes: doi: 10.1136/openhrt-2021-001648.

Kini LG, Thaker AA, Hadar PN, Shinohara RT, Brown MG, Dubroff JG*, Davis KA*: Quantitative [18F]FDG PET asymmetry features predict long-term seizure recurrence in refractory epilepsy. Epilepsy & Behavior 116(107714), Mar 2021 Notes: *joint senior authors.

Guerraty MA, Rao S, Anjan VY, Szapary H, Mankoff DA, Pryma DA, Rader DJ, and Dubroff JG : The role of resting myocardial blood flow and myocardial blood flow reserve as a predictor of major adverse cardiovascular outcomes Plos One 15(2), Feb 2020 Notes: doi: 10.1371/journal.pone.0228931.

Pantel AR, Viswanath V, Daube-Witherspoon ME, Dubroff JG, Muehllehner G, Parma MJ, Pryma DA, Schubert EK, Mankoff DA, and Karp JS: PennPET Explorer: Human Imaging on a Whole-body Imager. J Nucl Med 61(1): 144-151, Jan 2020 Notes: doi: 10.2967/jnumed.119.231845.

Doot RK, Dubroff JG, Scheuermann JS, Labban KJ, Cai J, Hsieh CJ, Li S, Lee H, Schubert EK, Hou C, Sheffer R, Schmitz A, Xu K, and Mach RH: Validation of gallbladder absorbed radiation dose reduction simulation: Human dosimetry of [18F]fluortriopride. EJNMMI Physics 5(21), Oct 2018 Notes:

Booij J, Dubroff J, Pryma D, Yu J, Agarwal R, Lakhani P, and Kuo PH : Diagnostic performance of the visual reading of 123I-ioflupane SPECT images when assessed with or without quantification in patients with movement disorders or dementia. J Nucl Med 58(11): 1821-26, Nov 2017 Notes: DOI: 10.2967/jnumed.116.189266.

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Last updated: 04/24/2022
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