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Jacob Dubroff, MD, PhD

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Assistant Professor of Radiology at the Hospital of the University of Pennsylvania
Active Radiologist, Penn Presbyterian Medical Center
Active Radiologist, Pennsylvania Hospital
Attending Radiologist, Hospital of the University of Pennsylvania
Modality Chief, Nuclear Medicine and PET, Hospital of the University of Pennsylvania
Department: Radiology

Contact information
Hospital of the University of Pennsylvania
Department of Radiology
Division of Nuclear Imaging and Therapy
3400 Spruce Street
1 Silverstein
Philadelphia, PA 19104
Office: 215-662-3041
Fax: 215-349-5843
Graduate Group Affiliations
BA (History and Sociology of Science)
University of Pennsylvania Philadelphia, PA, 1997.
BAS (Biomedical Engineering)
University of Pennsylvania Philadelphia, PA, 1997.
PhD (Neuroscience)
SUNY Upstate Medical University Syracuse, NY, 2006.
MD (Medicine)
SUNY Upstate Medical University Syracuse, NY, 2006.
Post-Graduate Training
Intern, Transitional Year, Frankford Hospitals, Jefferson Health System , 2006-2007.
Resident, Nuclear Medicine, Hospital of the University of Pennsylvania, 2007-2009.
Chief Resident, Nuclear Medicine, Hospital of the University of Pennsylvania, 2009-2010.
United State Medical License Examination, 2007.
Authorized User, Broad Scope License #PA-0131, PA, 2010.
American Board of Nuclear Medicine, 2010.
ACLS (initial certification 2/2005), 2020.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Description of Clinical Expertise

PET Brain Imaging of Dementia and Epilepsy
SPECT Brain Imaging of Parkinson's Disease
PET/CT Oncologic Imaging
PET Myocardial Imaging
Radionuclide Therapy
General Nuclear Medicine

Description of Other Expertise

Dr. Dubroff is clinician scientist who uses Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography to better understand the molecular mechanisms of drug abuse, including nicotine dependence and opioid use disorder, as well as neurodegenerative disease, including Parkinson's and Alzheimer's diseases. He collaborates with investigators in the Departments of Psychiatry and Neurology. His studies are supported by the National Institute of Drug Abuse (NIDA), the National Heart, Lung, and Blood Institute (NHLBI), the Michael J. Fox Foundation, and industry.

Description of Research Expertise

Neuroreceptor PET Imaging
Molecular Imaging of Neurological and Psychiatric Disease
Cardiac PET Imaging
Brain Plasticity

Selected Publications

Wetheril RR, Doot RK, Young AJ, Lee H, Schubert EK, Wiers CE, Leone FT, Mach RH, Kranzler HR, Dubroff JG: Using 18F-NOS PET Imaging to Measure Pulmonary Inflammation in Electronic and Combustible Cigarette Users: A Pilot Study. J Nucl Med jan 2023 Notes: doi: 10.2967/jnumed.122.264529. Online ahead of print.

Rojulpote C, Bhattaru A, Jean C, Patel V, Vidula M, Selvaraj S, Chandra A, Dubroff J, Peyster E, Clancy C, Patterson K, Marchlinski F, Rossman M, Goldberg L, and Bravo P : Effect of Timing, Immunotherapy, and Biopsy-Status in Monitoring Therapy Response in Suspected Cardiac Sarcoidosis. JACC: Cardiovascular Imaging 15(11): 1944-1955, October 2022.

Love T, Shabalin A, Kember R, Docherty A, Zhou H, Koppelmans V, Gelernter J, Baker A, Hartwell E, Dubroff J, Zubieta JK, and Kranzler HR: Unique and Joint Associations of Polygenic Risk for Major Depression and Opioid Use Disorder with Endogenous Opioid System Function. Neuropsychopharmacology 47(10): 1784-90, Sep 2022 Notes: doi: 10.1038/s41386-022-01325-1.

Schroeder JA, Cao Q, Sotirchos VS,Gillman JA, Anderson T, Pilati S, Dubroff JG, Farwell M, Kozlov A, Korhonen K, Pryma DA, Pantel AR: Perfusion-only Imaging in Pregnant Women: A Comparative Reader Study with Implications for Practice Patterns. Medicine 101(39), Sep 2022.

Doot RK, Young AJ, Nasrallah IN, Wetherill RR, Siderowf A, Mach RH, Dubroff JG: [18F]NOS PET brain imaging suggests elevated neuroinflammation in idiopathic Parkinson’s disease. Cells 11(19): 3081, Sep 2022.

Zuroff L, Wisseb LEM, Glenn T, Xie S, Nasrallah I, Habes M, Dubroff J, de Flores R, Xie L, Yushkevich P, Doshi J, Davatsikos C, Wolka DA, Dasa S, Mechanic-Hamilton D: Self- and partner-reported subjective memory complaints: association with objective cognitive impairment and risk of decline. JAD reports 6(1): 411-430, Jul 2022.

Phillips JS, Nitchie FJ, Da Re F, Olm CA, Cook PA, McMillan CT, Gee JC, Dubroff JG, Grossman M, Nasrallah IM: Rates of longitudinal change in 18F-flortaucipir PET vary by brain region, cognitive impairment, and age in atypical Alzheimer's disease. Alzheimer's & Dementia 18(6): 1235-47, Jun 2022 Notes: doi: 10.1002/alz.12456. Epub 2021 Sep 13.

Aamodt WW, Dubroff JG, Cheng G, Taylor B, Wood S, Duda JE, and Morley JF : Gait abnormalities and non-motor symptoms predict abnormal dopaminergic imaging in presumed drug-induced parkinsonism npj Parkinson's Disease 8(1): 53, Apr 2022.

Patterson KC, Rosenbach M, Bravo PE, Dubroff JG: Stable Extent of Recurrently Active Cardiac and Cutaneous Sarcoidosis. Front Med (Lausanne) 8(729229), Dec 2021 Notes: doi: 10.3389/fmed.2021.729229.

Selvaraj S, Khan MS, Wiener PC, de Feria A, Rojulpote C, Julien H, Jacoby D, Litt H, Pryma D, Dubroff J, Guerraty MA, Bravo P: Incremental Prognostic Value of Visually Estimated Coronary Artery Calcium in Patients Undergoing Positron Emission Tomography Imaging. Open Heart 8(1), May 2021 Notes: doi: 10.1136/openhrt-2021-001648.

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Last updated: 03/21/2023
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