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David A Mankoff, MD, PhD

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Matthew J. Wilson Professor of Research Radiology
Active Physician, Penn Presbyterian Medical Center
Active Physician, Pennsylvania Hospital
Attending, Department of Radiology, Hospital of the University of Pennsylvania
Vice-Chair of Research, Department of Radiology, University of Pennsylvania
Associate Director of Education and Research, Abramson Cancer Center
PET Center Director, University of Pennslyvania
Department: Radiology

Contact information
Division of Nuclear Medicine
Department of Radiology
Perelman School of Medicine, University of Pennsylvania
1 Donner, HUP
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-746-4062
Fax: 215-349-5843
Graduate Group Affiliations
B.S. (Physics)
Yale University, 1981.
Ph.D. (Bioengineering)
University of Pennsylvania, 1988.
M.D. (Medicine)
University of Pennsylvania, 1988.
Post-Graduate Training
Research Associate, Nuclear Medicine Section (part-time), University of Pennsylvania, 1988-1990.
Resident, Department of Internal Medicine, University of Washington Affiliated Hospitals, Seattle, WA , 1990-1992.
Resident, Division of Nuclear Medicine, University of Washington Affiliated Hospitals, Seattle, WA , 1992-1995.
Completed NMBE Examinations (Parts I-III) , 1991.
American Board of Internal Medicine, Certification for General Internal Medicine, 1993.
American Board of Nuclear Medicine, Certification for Nuclear Medicine (re-certification 2005, 2007), 1995.
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Description of Clinical Expertise

Nuclear Medicine/PET
Radionuclide Therapy
Thyroid Cancer

Description of Other Expertise

Susan G. Komen Scholar Emeritus

Description of Research Expertise

Molecular Imaging
Breast Cancer
Quantitative Cancer Imaging and Image Analysis
Translational Clinical Trials

Selected Publications

Zhou, R., Choi, H., Cao, J., Pantel, A., Gupta, M., Lee, H. S., Mankoff, D.: (18)F-Fluciclovine PET Imaging of Glutaminase Inhibition in Breast Cancer Models. J Nucl Med 64(1): 131-136, 2023.

O'Brien, S. R., Edmonds, C. E., Lanzo, S. M., Weeks, J. K., Mankoff, D. A., Pantel, A. R.: (18)F-Fluoroestradiol: Current Applications and Future Directions. Radiographics 43(3): e220143, 2023.

Pantel AR, Gitto SB, Makvandi M, Kim H, MedvedvS , Weeks JF, Torigian DA, Hsieh CJ, Ferman B, Latif NA, Tanyi JL, Martin LP, Lanzo SM, Liu F, Cao Q, Mills GB, Doot RK, Mankoff DA, Mach RH, Lin L, Simpkins F: [18F]FluorThanatrace ([18F]FTT) PET Imaging of PARP-inhibitor Drug-Target Engagement as a Biomarker of Response in Ovarian Cancer, a pilot study. Clin Cancer Res accepted for publication, 2022.

Lee, I. K., Jacome, D. A., Cho, J. K., Tu, V., Young, A. J., Dominguez, T., Northrup, J. D., Etersque, J. M., Lee, H. S., Ruff, A., Aklilu, O., Bittinger, K., Glaser, L. J., Dorgan, D., Hadjiliadis, D., Kohli, R. M., Mach, R. H., Mankoff, D. A., Doot, R. K., Sellmyer, M. A.: Imaging sensitive and drug-resistant bacterial infection with [11C]-trimethoprim. J Clin Invest 132(18), 2022.

Chitalia, R., Viswanath, V., Pantel, A. R., Peterson, L. M., Gastounioti, A., Cohen, E. A., Muzi, M., Karp, J., Mankoff, D. A., Kontos, D.: Functional 4-D clustering for characterizing intratumor heterogeneity in dynamic imaging: evaluation in FDG PET as a prognostic biomarker for breast cancer. Eur J Nucl Med Mol Imaging 2021.

Viswanath, V., Zhou, R., Lee, H., Li, S., Cragin, A., Doot, R. K., Mankoff, D. A., Pantel, A. R.: Kinetic Modeling of (18)F-(2S,4R)4-Fluoroglutamine in Mouse Models of Breast Cancer to Estimate Glutamine Pool Size as an Indicator of Tumor Glutamine Metabolism. J Nucl Med 62(8): 1154-1162, 2021.

Pantel, A. R., Viswanath, V., Daube-Witherspoon, M. E., Dubroff, J. G., Muehllehner, G., Parma, M. J., Pryma, D. A., Schubert, E. K., Mankoff, D. A., Karp, J. S.: PennPET Explorer: Human Imaging on a Whole-Body Imager. J Nucl Med 61(1): 144-151, 2020.

McDonald, E. S., Doot, R. K., Pantel, A. R., Farwell, M. D., Mach, R. H., Maxwell, K. N., Mankoff, D. A.: Positron Emission Tomography Imaging of Poly-(Adenosine Diphosphate-Ribose) Polymerase 1 Expression in Breast Cancer: A Nonrandomized Clinical Trial. JAMA Oncol April 2020.

Elmi, A., Makvandi, M., Weng, C. C., Hou, C., Clark, A. S., Mach, R. H., Mankoff, D. A.: Cell-Proliferation Imaging for Monitoring Response to CDK4/6 Inhibition Combined with Endocrine-Therapy in Breast Cancer: Comparison of [(18)F]FLT and [(18)F]ISO-1 PET/CT. Clin Cancer Res 25(10): 3063-3073, 2019.

Zhou, R., Pantel, A. R., Li, S., Lieberman, B. P., Ploessl, K., Choi, H., Blankemeyer, E., Lee, H., Kung, H. F., Mach, R. H., Mankoff, D. A.: [18F](2S,4R)4-Fluoroglutamine PET Detects Glutamine Pool Size Changes in Triple-Negative Breast Cancer in Response to Glutaminase Inhibition. Cancer Res 77(6): 1476-1484, Mar 2017 Notes: Epub 2017 Feb 15.

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Last updated: 05/24/2023
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