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David A Mankoff, MD, PhD

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Matthew J. Wilson Professor of Research Radiology
Active Physician, Penn Presbyterian Medical Center
Active Physician, Pennsylvania Hospital
Attending, Department of Radiology, Hospital of the University of Pennsylvania
Vice-Chair of Research, Department of Radiology, University of Pennsylvania
Associate Director of Education and Research, Abramson Cancer Center
PET Center Director, University of Pennslyvania
Department: Radiology

Contact information
Division of Nuclear Medicine
Department of Radiology
Perelman School of Medicine, University of Pennsylvania
1 Donner, HUP
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-746-4062
Fax: 215-349-5843
Graduate Group Affiliations
B.S. (Physics)
Yale University, 1981.
Ph.D. (Bioengineering)
University of Pennsylvania, 1988.
M.D. (Medicine)
University of Pennsylvania, 1988.
Post-Graduate Training
Research Associate, Nuclear Medicine Section (part-time), University of Pennsylvania, 1988-1990.
Resident, Department of Internal Medicine, University of Washington Affiliated Hospitals, Seattle, WA , 1990-1992.
Resident, Division of Nuclear Medicine, University of Washington Affiliated Hospitals, Seattle, WA , 1992-1995.
Completed NMBE Examinations (Parts I-III) , 1991.
American Board of Internal Medicine, Certification for General Internal Medicine, 1993.
American Board of Nuclear Medicine, Certification for Nuclear Medicine (re-certification 2005, 2007), 1995.
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Description of Clinical Expertise

Nuclear Medicine/PET
Radionuclide Therapy
Thyroid Cancer

Description of Other Expertise

Susan G. Komen Scholar Emeritus

Description of Research Expertise

Molecular Imaging
Breast Cancer
Quantitative Cancer Imaging and Image Analysis
Translational Clinical Trials

Selected Publications

Young, A. J., Pantel, A. R., Viswanath, V., Dominguez, T. L., Makvandi, M., Lee, H., Li, S., Schubert, E. K., Pryma, D. A., Farwell, M. D., Mach, R. H., Simpkins, F., Lin, L. L., Mankoff, D. A., Doot, R. K.: Kinetic and Static Analysis of Poly-(Adenosine Diphosphate-Ribose) Polymerase-1-Targeted (18)F-Fluorthanatrace PET Images of Ovarian Cancer. J Nucl Med 63(1): 44-50, 2022.

Chitalia, R., Viswanath, V., Pantel, A. R., Peterson, L. M., Gastounioti, A., Cohen, E. A., Muzi, M., Karp, J., Mankoff, D. A., Kontos, D.: Functional 4-D clustering for characterizing intratumor heterogeneity in dynamic imaging: evaluation in FDG PET as a prognostic biomarker for breast cancer. Eur J Nucl Med Mol Imaging 2021.

Viswanath, V., Zhou, R., Lee, H., Li, S., Cragin, A., Doot, R. K., Mankoff, D. A., Pantel, A. R.: Kinetic Modeling of (18)F-(2S,4R)4-Fluoroglutamine in Mouse Models of Breast Cancer to Estimate Glutamine Pool Size as an Indicator of Tumor Glutamine Metabolism. J Nucl Med 62(8): 1154-1162, 2021.

Sellmyer, M. A., Lee, I. K., Mankoff, D. A.: Building the Bridge: Molecular Imaging Biomarkers for 21(st) Century Cancer Therapies. J Nucl Med 2021.

Romine, P. E., Peterson, L. M., Kurland, B. F., Byrd, D. W., Novakova-Jiresova, A., Muzi, M., Specht, J. M., Doot, R. K., Link, J. M., Krohn, K. A., Kinahan, P. E., Mankoff, D. A., Linden, H. M.: (18)F-fluorodeoxyglucose (FDG) PET or (18)F-fluorothymidine (FLT) PET to assess early response to aromatase inhibitors (AI) in women with ER+ operable breast cancer in a window-of-opportunity study. Breast Cancer Res 23(1): 88, 2021.

Pantel, A. R., Viswanath, V., Daube-Witherspoon, M. E., Dubroff, J. G., Muehllehner, G., Parma, M. J., Pryma, D. A., Schubert, E. K., Mankoff, D. A., Karp, J. S.: PennPET Explorer: Human Imaging on a Whole-Body Imager. J Nucl Med 61(1): 144-151, 2020.

McDonald, E. S., Doot, R. K., Pantel, A. R., Farwell, M. D., Mach, R. H., Maxwell, K. N., Mankoff, D. A.: Positron Emission Tomography Imaging of Poly-(Adenosine Diphosphate-Ribose) Polymerase 1 Expression in Breast Cancer: A Nonrandomized Clinical Trial. JAMA Oncol April 2020.

Elmi, A., Makvandi, M., Weng, C. C., Hou, C., Clark, A. S., Mach, R. H., Mankoff, D. A.: Cell-Proliferation Imaging for Monitoring Response to CDK4/6 Inhibition Combined with Endocrine-Therapy in Breast Cancer: Comparison of [(18)F]FLT and [(18)F]ISO-1 PET/CT. Clin Cancer Res 25(10): 3063-3073, 2019.

Zhou, R., Pantel, A. R., Li, S., Lieberman, B. P., Ploessl, K., Choi, H., Blankemeyer, E., Lee, H., Kung, H. F., Mach, R. H., Mankoff, D. A.: [18F](2S,4R)4-Fluoroglutamine PET Detects Glutamine Pool Size Changes in Triple-Negative Breast Cancer in Response to Glutaminase Inhibition. Cancer Res 77(6): 1476-1484, Mar 2017 Notes: Epub 2017 Feb 15.

Makvandi M, Pantel A, Schwartz L, Schubert E, Xu K, Hsieh CJ, Hou C, Kim H, Weng CC, Winters H, Doot R, Farwell MD, Pryma DA, Greenberg RA, Mankoff DA, Simpkins F, Mach RH, Lin LL: A PET imaging agent for evaluating PARP-1 expression in ovarian cancer. J Clin Invest 128(5): 2116-2126, 2018.

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Last updated: 11/12/2022
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