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Gregory J. Nadolski, M.D.

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Assistant Professor of Radiology at the Hospital of the University of Pennsylvania
Co-Director, Penn Image Guided Interventions (PIGI) Laboratory
Active Radiologist, Pennsylvania Hospital
Active Radiologist, Penn Presbyterian Medical Center
Attending Radiologist, Philadelphia Veteran's Affairs Medical Center
Attending Radiologist, Hospital of the University of Pennsylvania
Center for Lymphatic Imaging and Interventions, University of Pennsylvania
Department: Radiology

Contact information
Hospital of the University of Pennsylvania
Department of Radiology
1 Silverstein
3400 Spruce Street
Philadelphia, PA 19104
Office: 215.662.7892
Fax: 215.615.3545
B.S. (Biochemistry)
University of Wisconsin, Madison, WI , 2001.
M.D. (Medicine)
Indiana University School of Medicine, Indianapolis, IN , 2007.
MS (Translational Research)
University of Pennsylvania, 2017.
Post-Graduate Training
Intern, Surgery, DIRECT Pathway, Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA , 2007-2009.
Resident, Diagnostic Radiology, DIRECT Pathway, Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA , 2009-2011.
Fellow, Interventional Radiology, DIRECT Pathway, Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA , 2011-2012.
Resident, Diagnostic Radiology, DIRECT Pathway, Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA , 2012-2013.
ACLS certified , 2007.
American Board of Radiology , 2013.
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Description of Clinical Expertise

My research and clinical interests include multimodality therapies for the treatment of hepatocellular carcinoma and liver dominant metastatic cancer.

I have initiated two clinical trials at the Hospital of the University of Pennsylvania for treating hepatocellular carcinoma. One involves combining transcatheter embolization with external beam radiation, and the other combines transcatheter embolization with an investigational oral chemotherapeutics.

Clinical Trials:
1. A Pilot Trial of Transarterial Chemoembolization With or Without Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma Patients Awaiting Liver Transplantation, Hospital of the University of Pennsylvania (UPCC16213)

2. Phase I-II Clinical Trial of the Safety of Hydroxychloroquine Combined with Transarterial Chemoembolization for Unresectable Hepatocellular Carcinoma, Hospital of the University of Pennsylvania (UPCC22213)

My other area of clinical and research interest is lymphatic injury, dysfunction, and malformations. Clinically, I perform thoracic duct embolization to treat chylothorax. I participate in research investigating novel lymphatic interventions to treat chylothorax, chylous ascites, refractory ascites and protein losing enteropathy.

Description of Research Expertise

In addition to my research investigating lymphatic interventions and multimodality cancer therapies, I also conduct research on vascular remodeling as it relates to hemodialysis access malfunction and peripheral arterial disease.

In this research, I am investigating a minimally invasive near infrared imaging system to evaluate hemodialysis access. The goal of this research is to detect changes in blood vessels that lead to stenosis before it becomes symptomatic. Detection of such changes at any early stage could improve development and monitor response of therapies to treat vascular disease.

Selected Publications

Gade TP, Tucker E, Nakazawa MS, Hunt SJ, Wong W, Krock B, Weber CN, Nadolski GJ, Clark TW, Soulen MC, Furth EE, Winkler JD, Amaravadi RK, Simon MC: Ischemia Induces Quiescence and Autophagy Dependence in Hepatocellular Carcinoma. Radiology Epub Ahead of Print, March 2017.

Chao C, Stavropoulos SW, Mondschein JI, Dagli M, Sudheendra D, Nadolski G, Soulen MC: Effect of Substituting 50% Isovue for Sterile Water as the Delivery Medium for SIR-Spheres: Improved Dose Delivery and Decreased Incidence of Stasis. Clinical Nuclear Medicine 42(3): 176-9, March 2017.

Shilpa N. Reddy, MD1, Christopher M. McGinn, MD1, Samantha Butts, MD2, Gregory J. Nadolski, MD1, Scott O. Trerotola, MD1, S. William Stavropoulos, MD1, Richard Shlansky-Goldberg, MD1: Outcomes of Abdominal Myomectomy vs Uterine Fibroid Embolization in Morbidly Obese Women. JVIR 28(S2): S46, February 2017.

P Habibollahi, S Hunt, T Gade, B Shin, M Dagli, J Mondschein, D Sudheendra, S Stavropoulos, M Soulen, G Nadolski : Neoadjuvant Locoregional Therapy and Long Term Outcomes of Patients with Hepatocellular Carcinoma Listed for Orthotopic Liver Transplantation. JVIR 28(2S): S17, February 2017.

J.C. Wildenberg, T.S. Cook, T.P. Gade, S.J. Hunt, M.C. Soulen, G.J. Nadolski: HCC Screening Behavior and IR Interventions at a Tertiary Transplant Center. JVIR 28(S2): S96, February 2017.

C Lance, S Hunt, T Clark, S Stavropoulos, M Soulen, S Trerotola, G Nadolski, T Gade: Endoscopic Findings after Embolization for Upper Gastrointestinal Hemorrhage. JVIR 28(2S): S34-35, February 2017.

S Hunt, M Silk, J Sprinkle, G Nadolski, T Gade, A Hillier: Geospatial mapping of interventional radiology physician density. JVIR 28(S2): S156, February 2017.

James X. Chen, Mike Noji, Ryan Kiefer, Michael C. Soulen, Stephen J. Hunt, Gregory J. Nadolski, Junwei Shi and Terence P. Gade : Comparison of techniques for establishment and propagation of primary cultured cell lines from hepatocellular carcinoma core needle biopsy samples JVIR 28(S2): S180-1, February 2017.

Omar Abousoud; Stephen Hunt; Terence Gade; Mandeep S Dagli; Jeffrey I. Mondschein; Deepak Sudheendra; William S. Stavropoulos; Michael C. Soulen; Gregory Nadolski: Comparison of infection rates in patients with prior biliary interventions undergoing hepatic embolotherapy treated with single-drug moxifloxacin versus multi-drug antibiotic prophylaxis. JVIR 28(S2): S208-9, February 2017.

Depietro D, Kiefer R, Trerotola S, Nadolski G, Hunt S, Redmond J: Increasing first-year medical student exposure to interventional radiology: a pilot-study of integrating IR into the gross anatomy lab. JVIR 28(S2): S21, February 2017.

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Last updated: 05/03/2017
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