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Gregory J. Nadolski, M.D.

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Assistant Professor of Radiology at the Hospital of the University of Pennsylvania
Co-Director, Penn Image Guided Interventions (PIGI) Laboratory
Active Radiologist, Pennsylvania Hospital
Active Radiologist, Penn Presbyterian Medical Center
Attending Radiologist, Hospital of the University of Pennsylvania
Attending Radiologist, Philadelphia Veteran's Affairs Medical Center
Director Research Oversight, Interventional Radiology University of Pennsylvania
Center for Lymphatic Imaging and Interventions, University of Pennsylvania
Chair IR/DR Residency Selection Committee, University of Pennsylvania
Department: Radiology

Contact information
Hospital of the University of Pennsylvania
Department of Radiology
1 Silverstein
3400 Spruce Street
Philadelphia, PA 19104
Office: 215.662.7892
Fax: 215.615.3545
B.S. (Biochemistry)
University of Wisconsin, Madison, WI , 2001.
M.D. (Medicine)
Indiana University School of Medicine, Indianapolis, IN , 2007.
MS (Translational Research)
University of Pennsylvania, 2017.
Post-Graduate Training
Intern, Surgery, DIRECT Pathway, Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA , 2007-2009.
Resident, Diagnostic Radiology, DIRECT Pathway, Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA , 2009-2011.
Fellow, Interventional Radiology, DIRECT Pathway, Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA , 2011-2012.
Resident, Diagnostic Radiology, DIRECT Pathway, Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA , 2012-2013.
ACLS certified , 2007.
American Board of Radiology , 2013.
Certificate in Interventional Radiology/Diagnostic Radiology, 2017.
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Description of Clinical Expertise

My research and clinical interests include multimodality therapies for the treatment of hepatocellular carcinoma and liver dominant metastatic cancer.

I have initiated two clinical trials at the Hospital of the University of Pennsylvania for treating hepatocellular carcinoma. One involves combining transcatheter embolization with external beam radiation, and the other combines transcatheter embolization with an investigational oral chemotherapeutics.

Clinical Trials:
1. A Pilot Trial of Transarterial Chemoembolization With or Without Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma Patients Awaiting Liver Transplantation, Hospital of the University of Pennsylvania (UPCC16213)

2. Phase I-II Clinical Trial of the Safety of Hydroxychloroquine Combined with Transarterial Chemoembolization for Unresectable Hepatocellular Carcinoma, Hospital of the University of Pennsylvania (UPCC22213)

My other area of clinical and research interest is lymphatic injury, dysfunction, and malformations. Clinically, I perform thoracic duct embolization to treat chylothorax. I participate in research investigating novel lymphatic interventions to treat chylothorax, chylous ascites, refractory ascites and protein losing enteropathy.

Description of Research Expertise

In addition to my research investigating lymphatic interventions and multimodality cancer therapies, I also conduct research on vascular remodeling as it relates to hemodialysis access malfunction and peripheral arterial disease.

In this research, I am investigating a minimally invasive near infrared imaging system to evaluate hemodialysis access. The goal of this research is to detect changes in blood vessels that lead to stenosis before it becomes symptomatic. Detection of such changes at any early stage could improve development and monitor response of therapies to treat vascular disease.

Selected Publications

Nadolski GJ, Ponce-Dorrego MD, Darge K, Biko DM, Itkin M: Validation of the Position of Injection Needles with Contrast-Enhanced Ultrasound for Dynamic Contract-Enhanced MR Lymphangiography. JVIR 29(7): 1028-1030, July 2018.

Buggert M, Nguyen S, Salgado-Montes de Oca G, Bengsch B, Darko S, Ransier A, Roberts ER, Del Alcazar D, Brody IB, Vella LA, Beura L, Wijeyesinghe S, Herati RS, Del Rio Estrada PM, Ablanedo-Terrazas Y, Kuri-Cervantes L, Sada Japp A, Manne S, Vartanian S, Huffman A, Sandberg JK, Gostick E, Nadolski G, Silvestri G, Canaday DH, Price DA, Petrovas C, Su LF, Vahedi G, Dori Y, Frank I, Itkin MG, Wherry EJ, Deeks SG, Naji A, Reyes-Terán G, Masopust D, Douek DC, Betts MR: Identification and characterization of HIV-specific resident memory CD8+ T cells in human lymphoid tissue. Science Immunology 3(24), June 2018.

G. Nadolski, A. Salute, T. Robertson, S. Trerotola: Initial experience with Arrow ClearClot over-the-wire thrombectomy device in an in vivo model of iliocaval thrombosis. JVIR 29(4): S273, Apr 2018.

Voillet V, Buggert M, Slichter CK, Berkson JD, Mair F, Addison MM, Dori Y, Nadolski G, Itkin MG, Gottardo R, Betts MR, Prlic M: Human MAIT cells exit peripheral tissues and recirculate via lymph in steady state conditions. JCI Insight 3(7), April 2018 Notes: Epub ahead of print.

R. Kiefer, E. Profka, M. Pourfathi, G. Nadolski, S. Hunt, T. Gade: Analysis of in vivo tumor growth kinetics in a diethylnitrosamine-induced, transarterial embolization-treated rat model of hepatocellular carcinoma. JVIR 29(4): S137–S138, April 2018.

M. Ponce-Dorrego, D. Biko, K. Darge, G. Nadolski, M. Itkin: Confirmation of the needle position for dynamic contrast-enhanced MR lymphangiography using us contrast. JVIR 29(4): S205-6, Apr 2018.

A. Smolock, G. Nadolski, M. Itkin: Lymphatic embolization for the treatment of postprocedural inguinal lymphatic leaks. JVIR 29(4): S32–S33, April 2018.

E. Alexander, G. Nadolski, M. Soulen, S. Stavropoulos, S. Hunt, T. Gade, M. Itkin, S. Shamimi-Noori: Iatrogenic celiac axis and hepatic artery dissections during intra-arterial regional tumor therapies: a 16-year retrospective review. JVIR 29(4): S116–S117, Apr 2018.

P. Habibollahi, S Pourhassan Shamchi, S. Hunt, T. Gade, S. Stavropoulos, M. Soulen, G. Nadolski: Association of radiological complete response following locoregional therapy prior to liver transplantation with long-term outcomes of hepatocellular carcinoma patients. JVIR 29(4): S222–S223, April 2018.

M. Silk, J. Benjamin, D. Ackerman, M. Noji, G. Nadolski, S. Hunt, T. Gade: Developing TACE 2.0: targeting hepatocellular carcinoma epigenetic and ischemia survival pathways. JVIR 29(4): S136, Apr 2018.

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Last updated: 07/17/2018
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