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Mehran Makvandi, PharmD, RPh, BCNP

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Assistant Professor of Radiology at the Hospital of the University of Pennsylvania
Department: Radiology

Contact information
Perelman School of Medicine
University of Pennsylvania
Department of Radiology
Nuclear Medicine and Clinical Molecular Imaging
231 S. 34th Street
Philadelphia, PA 19104
Office: 215-746-8755
N/A (Chemistry)
University of New Mexico, 2009.
PharmD. (Pharmacology)
University of New Mexico, 2013.
Post-Graduate Training
Postdoctoral Research Fellowship, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, 2013-2016.
Basic Life Support (BLS), 2016.
Board Certified Nuclear Pharmacist, 2017.
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Selected Publications

Reilly SW, Puentes LN, Wilson K, Hsieh CJ, Weng CC, Makvandi M, Mach RH.: Examination of Diazaspiro Cores as Piperazine Bioisosteres in the Olaparib Framework Shows Reduced DNA Damage and Cytotoxicity. J Med Chem Jun 2018

Sean W. Reilly, Laura N. Puentes, Chia-Ju Hsieh, Mehran Makvandi, and Robert H. Mach: Altering Nitrogen Heterocycles of AZD2461 Affords High Affinity Poly(ADP-ribose) Polymerase-1 Inhibitors with Decreased P-Glycoprotein Interactions. ACS Omega. ACS, 3: 9997/10001, Aug 2018.

Makvandi M, Pantel A, Schwartz L, Schubert E, Xu K, Hsieh CJ, Hou C, Kim H, Weng CC, Winters H, Doot R, Farwell MD, Pryma DA, Greenberg RA, Mankoff DA, Simpkins F, Mach RH, Lin LL.: A PET imaging agent for evaluating PARP-1 expression in ovarian cancer. J Clin Invest. May 2018.

Makvandi M, Dupis E, Engle JW, Nortier FM, Fassbender ME, Simon S, Birnbaum ER, Atcher RW, John KD, Rixe O, Norenberg JP.: Alpha-Emitters and Targeted Alpha Therapy in Oncology: from Basic Science to Clinical Investigations. Target Oncol. Apr 2018.

Reilly SW, Makvandi M, Xu K, Mach RH.: Rapid Cu-Catalyzed [211At]Astatination and [125I]Iodination of Boronic Esters at Room Temperature. Org Lett Apr 2018.

Makvandi M, Sellmyer MA, Mach RH.: Inflammation and DNA damage: Probing pathways to cancer and neurodegeneration. Drug Discov Today Technol Nov 2017.

Batra V, Makvandi M, Zuppa AF, Patel N, Elias J, Pryma DA, Maris JM.: Dexmedetomidine does not interfere with meta-iodobenzylguanidine (MIBG) uptake at clinically relevant concentrations. Pediatr Blood Cancer 64(4): e26268, April 2017.

McDonald ES, Mankoff J, Makvandi M, Chu W, Chu Y, Mach RH, Zeng C.: Sigma-2 ligands and PARP inhibitors synergistically trigger cell death in breast cancer cells. Biochem Biophys Res Commun Mar 2017.

George E, Kim H, Krepler C, Wenz B, Makvandi M, Tanyi JL, Brown E, Zhang R, Brafford P, Jean S, Mach RH, Lu Y, Mills GB, Herlyn M, Morgan M, Zhang X, Soslow R, Drapkin R, Johnson N, Zheng Y, Cotsarelis G, Nathanson KL, Simpkins F.: A patient-derived-xenograft platform to study BRCA-deficient ovarian cancers. JCI Insight Jan 2017.

Sander Effron S, Makvandi M, Lin L, Xu K, Li S, Lee H, Hou C, Pryma DA, Koch C, Mach RH.: PARP-1 Expression Quantified by [18F]FluorThanatrace: A Biomarker of Response to PARP Inhibition Adjuvant to Radiation Therapy. Cancer Biother Radiopharm Jan 2017.

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Last updated: 10/03/2018
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