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Mehran Makvandi, PharmD

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Assistant Professor of Radiology at the Hospital of the University of Pennsylvania
Department: Radiology

Contact information
Perelman School of Medicine
University of Pennsylvania
Department of Radiology
Division of Nuclear Medicine Imaging and Therapy
JMB168A, John Morgan Building
3620 Hamilton Walk
Philadelphia PA, 19104
Philadelphia, PA 19104
Office: 215-746-8755
Graduate Group Affiliations
N/A (Chemistry)
University of New Mexico, 2009.
PharmD. (Pharmacology)
University of New Mexico, 2013.
Post-Graduate Training
Postdoctoral Research Fellowship, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, 2013-2016.
Basic Life Support (BLS), 2016.
Board Certified Nuclear Pharmacist, 2017.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Selected Publications

Sam Lemonick: Astatine is a chemistry puzzle that shows anticancer promise. Chemistry and Engineering News Magazine 98, Aug 2020.

Lee H, Riad A, Martorano P, Mansfield A, Samanta M, Batra V, Mach RH, Maris JM, Pryma DA, Makvandi M.: PARP-1-targeted Auger emitters display high-LET cytotoxic properties in vitro but show limited therapeutic utility in solid tumor models of human neuroblastoma. J Nucl Med. 61(6): 850-856, Jun 2020 Notes: DOI: 10.2967/jnumed.119.233965.

Ellison Paul A, Olson Aeli P, Barnhart Todd E, Hoffman Sabrina L V, Reilly Sean W, Makvandi Mehran, Bartels Jennifer L, Murali Dhanabalan, DeJesus Onofre T, Lapi Suzanne E, Bednarz Bryan, Nickles Robert J, Mach Robert H, Engle Jonathan W: Improved production of Br, Br and Br via CoSe cyclotron targets and vertical dry distillation. Nuclear medicine and biology 80(81): 32-36, Jan-Feb 2020 Notes: DOI: 10.1016/j.nucmedbio.2019.09.001.

Weng Chi-Chang, Carlin Sean, Hou Catherine, Metz Tyler, Li Shihong, Lee Hsiaoju, Xu Kuiying, Makvandi Mehran, Mach Robert H: Correlation analysis of [F]ROStrace using ex vivo autoradiography and dihydroethidium fluorescent imaging in lipopolysaccharide-treated animals. Biochemical and biophysical research communications 516(2): 397-401, Aug 2019.

Makvandi M, Lee H, Puentes LN, Reilly SW, Rathi KS, Weng CC, Chan HS, Hou C, Raman P, Martinez D, Xu K, Carlin SD, Greenberg RA, Pawel BR, Mach RH, Maris JM, Pryma DA.: Targeting PARP-1 with Alpha-Particles Is Potently Cytotoxic to Human Neuroblastoma in Preclinical Models. Mol Cancer Ther. 18(7): 1195-1204, Jul 2019 Notes: DOI: 10.1158/1535-7163.MCT-18-0837.

Editor Highlights: Alpha-particle therapy for the treatment of neuroblastoma-Editor Highlights. Mol Can Ther July 2019.

Elmi Azadeh, Makvandi Mehran, Weng Chi-Chang, Hou Catherine, Clark Amy S, Mach Robert H, Mankoff David A: Cell-Proliferation Imaging for Monitoring Response to CDK4/6 Inhibition Combined with Endocrine-Therapy in Breast Cancer: Comparison of [F]FLT and [F]ISO-1 PET/CT. Clinical cancer research 25(10): 3063-3073, May 2019 Notes: DOI: 10.1158/1078-0432.CCR-18-2769.

Reilly Sean W, Puentes Laura N, Schmitz Alexander, Hsieh Chia-Ju, Weng Chi-Chang, Hou Catherine, Li Shihong, Kuo Yin-Ming, Padakanti Prashanth, Lee Hsiaoju, Riad Aladdin A, Makvandi Mehran, Mach Robert H: Synthesis and evaluation of an AZD2461 [F]PET probe in non-human primates reveals the PARP-1 inhibitor to be non-blood-brain barrier penetrant. Bioorganic chemistry 83: 242-249, March 2019 Notes: DOI: 10.1016/j.bioorg.2018.10.015.

Zeng Chenbo, Weng Chi-Chang, Schneider Mark E, Puentes Laura, Riad Aladdin, Xu Kuiying, Makvandi Mehran, Jin Linda, Hawkins William G, Mach Robert H: TMEM97 and PGRMC1 do not mediate sigma-2 ligand-induced cell death. Cell death discovery 5: 58, January 2019 Notes: DOI: 10.1038/s41420-019-0141-2.

Reilly SW, Puentes LN, Hsieh CJ, Makvandi M, Mach RH.: Altering Nitrogen Heterocycles of AZD2461 Affords High Affinity Poly(ADP-ribose) Polymerase-1 Inhibitors with Decreased P-Glycoprotein Interactions. ACS Omega. 3(8): 9997-10001, Aug 2018 Notes: DOI: 10.1021/acsomega.8b00896.

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Last updated: 11/09/2020
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