Faculty & Staff

Alexander C. Wright, Ph.D.

faculty photo
Research Associate Professor of Radiology
Deputy Director, Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania School of Medicine
Technical Director, Micro-CT Scanner, Department of Radiology, University of Pennsylvania School of Medicine
Department: Radiology

Contact information
Radiology, 1 Silverstein
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-349-5295
Fax: 215-662-7263
B.S. (Physics)
Georgia Institute of Technology, 1986.
Ph.D. (Physics)
Georgia Institute of Technology, 1991.
Post-Graduate Training
Postdoctoral Fellow in Radiology, Medical University of South Carolina, 1993-1996.
Postdoctoral Fellow in Functional MRI, Electrical Engineering, and Physics, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 1996-1998.
Permanent link
> Perelman School of Medicine   > Faculty   > Details

Description of Research Expertise

Dr. Wright’s research involves the development of micro-MRI and micro-CT hardware, acquisition strategies and quantitative methods for the purpose of imaging the microstructure of biological tissues at cellular resolution. This includes the design and construction of novel and optimized radio-frequency and gradient coils for micro-MRI, and the development of quantitative image acquisition and analysis techniques for the characterization of tissue micro-architecture using both micro-MRI and micro-CT. Current focus is on developing micro-MRI methods for imaging the intervertebral disc ex vivo in order to measure collagen fiber architecture in the annulus fibrosus of the disc. In addition, micro-CT techniques are being developed for imaging and characterizing structural phenotypes in both soft-tissue and calcified specimens at extremely high resolution (1-10 µm isotropic). Another research effort involves the design, construction and implementation of transmit-receive RF coils for in vivo MRI of bone in the human tibia, using a whole-body 7 Tesla MRI scanner.

Selected Publications

J. H. Yoder, J. M. Peloquin, G. Song, N. J. Tustison, S. M. Moon, A. C. Wright, E. J. Vresilovic, J. C. Gee, D. M. Elliott: Internal three-dimensional strains in human intervertebral discs under axial compression quantified noninvasively by magnetic resonance imaging and image registration. Journal of Biomechanical Engineering 136(11): 111008 (9 pages), November 2014.

D. H. Cortes, J. F. Magland, A. C. Wright, D. M. Elliott: The shear modulus of the nucleus pulposus measured using magnetic resonance elastography: A potential biomarker for intervertebral disc degeneration. Magnetic Resonance in Medicine 72(1): 211-219, July 2014.

J. M. Peloquin, J. H. Yoder, N. T. Jacobs, S. M. Moon, A. C. Wright, E. J. Vresilovic, D. M. Elliott: Human L3L4 intervertebral disc mean 3D shape, modes of variation, and their relationship to degeneration. Journal of Biomechanics 47(10): 2452-2459, July 2014.

A. C. Seifert, C. Li, C. S. Rajapakse, M. Bashoor-Zadeh, Y. A. Bhagat, A. C. Wright, B. S. Zemel, A. Zavaliangos, F. W. Wehrli: Bone mineral (31)P and matrix-bound water densities measured by solid-state (31)P and (1)H MRI. NMR in Biomedicine 27(7): 739-748, July 2014.

A. C. Seifert, A. C. Wright, S. L. Wehrli, H. H. Ong, C. Li, F. W. Wehrli: 31P NMR relaxation of cortical bone mineral at multiple magnetic field strengths and levels of demineralization. NMR in Biomedicine 26(9): 1158-1166, September 2013.

S. M. Moon, J. H. Yoder, A. C. Wright, L. J. Smith, E. J. Vresilovic, D. M. Elliott: Evaluation of intervertebral disc cartilaginous endplate structure using magnetic resonance imaging. European Spine Journal 22(8): 1820-1828, August 2013.

M. Damek-Poprawa, S. Both, A. C. Wright, A. Maity, S. O. Akintoye: Onset of mandible and tibia osteoradionecrosis: a comparative pilot study in the rat. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 115(2): 201-211, February 2013.

H. H. Ong, A. C. Wright, F. W. Wehrli: Deuterium nuclear magnetic resonance unambiguously quantifies pore and collagen-bound water in cortical bone. Journal of Bone and Mineral Research 27(12): 2573-2581, December 2012.

S. A. Chakkalakal, D. Zhang, A. L. Culbert, M. R. Convente, R. J. Caron, A. C. Wright, A. D. Maidment, F. S. Kaplan, E. M. Shore: An Acvr1 R206H knock-in mouse has fibrodysplasia ossificans progressiva. Journal of Bone and Mineral Research 27(8): 1746-1756, August 2012.

P. Tsao, V. Arora, M. Q. Ji, A. C. Wright, R. Eisenberg: KRN/I-Ag7 mouse arthritis is independent of complement C3. Journal of Clinical Immunology 31(5): 857-863, October 2011.

back to top
Last updated: 02/12/2015
The Trustees of the University of Pennsylvania