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Gary D. Wu, M.D.

Ferdinand G. Weisbrod Professor in Gastroenterology
Associate Director NIH Training Grant in Gastrointestinal Sciences, University of Pennsylvania, School of Medicine(T32-DK07066)
Associate Director, Center for Molecular Studies in Digestive and Liver Disease Seminar Series , Hospital of the University of Pennsylvania
Director, Molecular Biology Core Facility, NIH Center for Molecular Studies in Digestive and Liver Diseases, Hospital of the University of Pennsylvania
Director, GI Fellow's Outpatient Clinic, University of Pennsylvania
Associate Chief for Research, GI Division, Hospital of the University of Pennsylvania
Co-Director, Penn-CHOP Center for Digestive, Liver and Pancreatic Medicine, Hospital of the University of Pennsylvania, Children's Hospital of Philadelphia
Co-Director, Penn-CHOP Microbiome Program , The University of Pennsylvania
Department: Medicine
Graduate Group Affiliations

Contact information
421 Curie Boulevard
9th Floor Biomedical Research Building
Philadelphia, PA 19104
Office: 215-898-0158
A.B. (Chemistry)
Cornell University, 1980.
Northwestern University Medical School, 1986.
M.A. (Honorary)
University of Pennsylvania, 2002.
Post-Graduate Training
Intern, University of Minnesota Hospital, 1986-1987.
Resident, University of Minnesota Hospital, 1987-1989.
Fellow (Gastroenterology), University of Michigan, Ann Arbor, 1989-1992.
Permanent link
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Description of Research Expertise

Research Program
Diet, the Gut Microbiome, and Host Metabolism

Program Summary
Dr. Wu is the Ferdinand G. Weisbrod Professor in Gastroenterology at the Perelman School of Medicine at the University of Pennsylvania where he is the Associate Chief for Research in the Division of Gastroenterology and is also the Associate Director of the Center for Molecular Studies in Digestive and Liver Disease. He is currently Director and Chair of the Scientific Advisory Board for the American Gastroenterological Association Center for Gut Microbiome Research and Education and is an elected member of both the American Society for Clinical Investigation and the American Association of Physicians. The research programs in the Wu laboratory focus on the mutualistic interactions between the gut microbiota and the host with a particular focus on metabolism. Growing evidence suggests that diet impacts upon both the structure and function of the gut microbiota that, in turn, influences the host in fundamental ways. Current areas of investigation include the effect of diet on the composition of the gut microbiota and its subsequence effect on host metabolism related to nitrogen balance as well as its impact on metabolic pathways in the intestinal epithelium, principally fatty acid oxidation. Through a UH3 roadmap initiate grant, he is helping to direct a project investigating the impact of diet on the composition of the gut microbiome and its relationship to therapeutic responses associated with the treatment of patients with Crohn’s disease using an elemental diet. Finally, Dr. Wu is leading a multidisciplinary group of investigators using phosphorescent nanoprobe technology to examine the dynamic oxygen equilibrium between the host and the gut microbiota at the intestinal mucosal interface.

Lab personnel:
Lindsay Albenberg
Lillian Chau
Christel Chehoud
Sue Ann Keilbaugh, PhD
Andrew Lin
Josephine Ni, MD
Ting-Chin David Shen, MD
Sarah Smith, PhD

Selected Publications

Kelsen J, Bittinger K, Pauly-Hubbard H, Posivak L, Grunberg S, Baldassano R, Lewis JD, Wu GD, Bushman FD: Alterations of the subgingival microbiota in pediatric Crohn's disease studied longitudinally in discovery and validation cohorts. Inflammatory Bowel Disease Epub ahead of print, August 2015.

Lee D, Baldassano RN, Otley AR, Albenberg L, Griffiths AM, Compher C, Chen EZ, Li H, Gilroy E, Nessel L, Grant A, Chehoud C, Bushman FD, Wu GD, Lewis JD: Comparative effectiveness of nutritional and biological therapy in North American children with active Crohn's Disease. Inflammatory Bowel Disease 21(8): 1786-93, August 2015.

Chehoud C, Albenberg LG, Judge C, Hoffmann C, Grunberg S, Bittinger K, Baldassano RN, Lewis JD, Bushman FD, Wu GD: Fungal signature in the gut microbiota of pediatric patients with inflammatory bowel disease. Inflammatory bowel diseases 21(8): 1948-56, August 2015.

Shen TC, Albenberg L, Bittinger K, Chehoud C, Chen YY, Judge CA, Chau L, Ni J, Sheng M, Lin A, Wilkins BJ, Buza EL, Lewis JD, Daikhin Y, Nissim I, Yudkoff M, Bushman FD, Wu GD: Engineering the gut microbiota to treat hyperammonemia. Journal of Clinical Investigation 125(7): 2841-50, July 2015.

Bryson AL, Hwang Y, Sherrill-Mix S, Wu GD, Lewis JD, Black L, Clark TA, Bushman FD: Covalent modification of bacteriophage T4 DNA inhibits CRISPR-Cas9. mBio 6(3): 00648-15, June 2015.

Wu GD, Compher C, Chen EZ, Smith SA, Shah RD, Bittinger K, Chehoud C, Albenberg LG, Nessel L, Gilroy E, Star J, Weljie AM, Flint HJ, Metz DC, Bennett MJ, Li H, Bushman FD, Lewis JD: Comparative metabolomics in vegans and omnivores reveal constraints on diet-dependent gut microbiota metabolite production. Gut Page: Epub ahead of print, November 2014.

Albenberg L, Esipova TV, Judge CP, Bittinger K, Chen J, Laughlin A, Grunberg S, Baldassano RN, Lewis JD, Li H, Thom SR, Bushman FD, Vinogradov SA, Wu GD: Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota. Gastroenterology 14(5): 1055-63, November 2014.

Bittinger K, Charlson ES, Loy E, Shirley DJ, Haas AR, Laughlin A, Yi Y, Wu GD, Lewis JD, Frank I, Cantu E, Diamond JM, Christie JD, Collman RG, Bushman FD: Improved characterization of medically relevant fungi in the human respiratory tract using next-generation sequencing. Genome Biology 15(10): 487, October 2014.

Wu, GD: Diet, the gut microbiome and the metabolome in IBD. Nestle Nutr Inst Workshop Series(79), 73-82, September 2014.

Lewis JD, Ruemmele FM, Wu GD: Nutrition, gut microbiota and immunity: therapeutic targets for IBD Nestlé Nutrition Workshop Series 79(161-2), September 2014.

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Last updated: 10/13/2015
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