Gwenn-ael H. Danet-Desnoyers, Ph.D.

faculty photo
Adjunct Associate Professor of Medicine (Hematology-Oncology)
Department: Medicine

Contact information
710 BRB-2/3
421 Curie Blvd
Philadelphia, PA 19104-6160
Office: 215-746-0181
Fax: 215-573-7049
Lab: 215-573-3705
Education:
B.S. (Biochemistry-Molecular Biology (Honors)
Sorbonne Université, Paris, France, 1988.
M.S. (Endocrinology-Biochemistry (High Honors))
Sorbonne Université, Paris, France, 1990.
PhD (Endocrinology-Biochemistry)
University of Florida, Gainesville, FL, 1994.
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Description of Research Expertise

Human hematopoietic and leukemic stem cells. Xenotransplantation models for the study of human cancers, immuno-oncology and immunotherapy.

Selected Publications

Danet-Desnoyers GH, Luongo JL, Bonnet DA, Domchek SM, Vonderheide RH: Telomerase Vaccination Has No Detectable Effect on SCID-Repopulating and Colony-Forming Activities in the Bone Marrow of Cancer Patients. Exp Hematol 33(11): 1275, Nov 2005.

Taussig D, Pearce D, Simpson C, Rohatiner AZ, Lister TA, Kelly G, Luongo JL, Danet-Desnoyers GH, Bonnet DA.: Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia. Blood 106(13): 4086, Dec 2005.

Danet GH, Yi P, Luongo JL, Bonnet D and Simon MC: Ex-vivo expansion of SCID-repopulating cells under hypoxic conditions. J. Clin. Invest. 112: 126, Mar 2003.

Danet GH, Luongo JL, Lu MM, Tenner AJ, Simon, Bonnet D.: C1qRp defines a new human stem cell population with hematopoietic and hepatic potential. Proc. Natl. Acad. Sci. 99(16): 10441, Aug 2002.

Wu MH, Smith SL, Danet GH, Lin AM, Williams SF, Liebowitz DN, Dolan ME.: Optimization of culture conditions to enhance transfection of human CD34+ cells by electroporation. Bone Marrow Transplant. 27(11): 1201-9, Jun 2001.

Danet GH, Lee HW, Luongo JL, Simon MC, Bonnet D.: Dissociation between phenotype and NOD/SCID repopulating cell activity in peripheral CD34+ cells after ex-vivo expansion. Exp. Hematol. 29(12): 1465, Dec 2001.

Danet GH, SL Smith, HW Lee, MV Bennett, TF Gajewski, SF Williams: Ex-vivo expansion of mononuclear cell-derived dendritic cells: optimization for clinical applications. J. Hematotherapy 7(3): 271, 1998.

Meyer MD, Danet-Desnoyers GH, Thatcher WW, Drost M, Schalue TK Roberts RM.: Treatment with recombinant bovine interferon-tau in utero attenuates secretion of prostaglandin F from cultured endometrial epithelial cells. J. Dairy Sci. 79(8): 1375-84, Aug 1996.

Danet-Desnoyers GH, Gross TS, Johnson JW, Thatcher WW.: Regulation of endometrial prostaglandin synthesis during early pregnancy in cattle: effects of phospholipases and calcium in vitro. Prostaglandins 50(5-6): 313-30, Nov-Dec 1995.

Thatcher WW, Meyer MD, Danet-Desnoyers GH.: Maternal recognition of pregnancy. J. Reprod. Fertil. 49: 15, Jun 1995.

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Last updated: 10/28/2020
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