Urs Giger, Dipl. ACVIM, ECVIM & ECVCP

faculty photo
Department: Medicine

Contact information
Section of Medical Genetics
Ryan Veterinary Hospital
University of Pennsylvania
School of Veterinary Medicine
3900 Delancey Street
Philadelphia, PA 19104-6010
Office: 215-898-8830
Fax: 215-573-2162
Lab: 215-898-3375/573-7545
DVM (Veterinary Medicine)
Veterinär-Medizinische Fakultät, University of Zürich, 1977.
PD (Internal Medicine)
University of Zürich, Switzerland, 1989.
MS (Comparative Sciences)
University of Pennsylvania, Philadelphia, 1990.
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Description of Research Expertise

Clinical Genetics, Hematology, Transfusion Medicine, Animal Models of Human Disease

Description of Clinical Expertise

Clinical Genetics, Hematology, and Transfusion Medicine in Companion Animals

Description of Other Expertise

Urs Giger received his veterinary degree from the University of Zürich, Switzerland, where he also pursued his doctoral thesis on the surgical repair of hip dysplasia, initial clinical training in small animal medicine and surgery and postgraduate research work. After moving to the United States, he completed a residency in small animal internal medicine at the University of Florida and then joined the faculty of the School of Veterinary Medicine at the University of Pennsylvania in Philadelphia where he has the endowed Charlotte Newton Sheppard Professor of Medicine chair. He has a secondary professorship in small animal internal medicine at the University of Zürich as well as professorship in hematology at the Medical School University of Pennsylvania. He is a diplomate of the American and European College of the Veterinary Internal Medicine, as well as a diplomate of the European College of Clinical Pathology. He headed the Transfusion and Hematology Center and Pediatrics and Genetics Clinic, and is/was the director of PennGen - the Metabolic Genetics, Hematology, Transfusion Medicine, DNA Genetic Disease Testing Laboratories. His clinical and research expertise and interests are in hereditary and hematologic disorders and are reflected in over 250 original research publications as well as many more reviews and scientific abstracts. He was also chairing the World Small Animal Veterinary Association (WSAVA) Hereditary Disease Committee. Among other awards, he was the recipient of a Transfusion Medicine Academic Award and Shannon Award from the National Institutes of Health, the 2002 WSAVA International Scientific Lifetime Achievement Award, the 2007 International Bourgelat Award from the BSAVA, the 2015 AVMA Excellence in Feline Research Award for outstanding clinical research in feline medicine and the 2018 Ramsey Distinguished Lecture Award from Iowa State University this year. He is a frequently invited speaker at national and international conferences.

Selected Publications

Inal Gultekin G, Raj K, Lehman S, Hillström A, Giger U.: Missense mutation in PFKM associated with muscle-type phosphofructokinase deficiency in the Wachtelhund dog. Molecular Cell Probes Page: epub, 2012.

Seth M, Jackson K,V, Winzelberg S, Giger U: Comparison of gel column, card and cartridge techniques for Dog Erythrocyte Antigen. Am J Vet Res 73: 213–219, 2012.

Inal Gultekin G, Raj K, Foureman P, Lehman S, Manhart K, Abdulmalik O, Giger U.: Erythrocytic pyruvate kinase mutations causing hemolytic anemia, osteosclerosis, and secondary hemochromatosis in dogs. J Vet Intern Med 26(4): 935–944, Jul 2012.

Jolly RD, Hopwood JJ, Marshall NR, Jenkins KS, Thompson DJ, Dittmer KE, Thompson JC, Fedele AO, Raj K, Giger U.: Mucopolysaccharidosis type VI in a Miniature Poodle-type dog caused by a deletion in the arylsulphatase B gene. NZ Vet J 60(3): 183-188, May 2012.

Seth M, Jackson KV, Giger U: Comparison of 5 blood typing methods for the feline AB blood group system. Am J Vet Res 72: 203-9, Feb 2011.

Patterson J, Rousseau A, Kessler RJ, Giger U: In vitro lysis and acute transfusion reactions with hemolysis caused by inappropriate storage of canine red blood cell products. J Vet Intern Med 25: 927-933, 2011.

Clavero S, Bishop DF, Giger U, Haskins ME, Desnick RJ: Feline congenital erythropoietic porphyria: Two homozygous UROS missense mutations cause the enzyme deficiency and porphyrin accumulation. Mol Med 16: 381-8, 2010.

Clavero S, Bishop DF, Haskins ME, Giger U, Kauppinen R, Desnick RJ: Feline acute intermittent porphyria: a phenocopy masquerading as an erythropoietic porphyria due to dominant and recessive hydroxymethylbilane synthase mutations. Hum Mol Genet 19: 584-96, 2010.

Margaritis P, Roy E, Aljamali MN, Downey HD, Giger U, Zhou S, Merricks E, Dillow A, Ezban M, Nichols TC, High KA.: Successful treatment of canine hemophilia by continuous expression of canine FVIIa. Blood 113(16): 3682-9, 2009.

Pontius JU, Mullikin JC, Smith DR; Agencourt Sequencing Team, Lindblad-Toh K, Gnerre S, Clamp M, Chang J, Stephens R, Neelam B, Volfovsky N, Schäffer AA, Agarwala R, Narfström K, Murphy WJ, Giger U, Roca AL, Antunes A, Menotti-Raymond M, Yuhki N, Pecon-Slattery J, Johnson WE, Bourque G, Tesler G; NISC Comparative Sequencing Program, O'Brien SJ: Initial sequence and comparative analysis of the cat genome. Genome Res. 17: 1675-89, 2007.

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Last updated: 04/19/2022
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