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Joseph Nicholas Jarvis, BSc,MSc,MBBS,MRCP,PhD,DTM&H

Adjunct Associate Professor of Medicine
Consultant Physician and Epidemiologist, Botswana-UPenn Partnership, University of Pennsylvania
Attending Physician, Princess Marina Hospital
Physician, HIV-treatment failure Clinic, Princess Marina Hospital
Director of Research , CDC Botswana Combination Prevention Project
Department: Medicine

Contact information
244G Botswana-UPenn Partnership
University of Botswana Main Campus
PO Box AC 157 ACH
Gaborone, PO
Office: +267 765 24122
BSc (Pharmacology)
University College London , 1998.
MBBS (Medicine )
University College London , 2001.
MRCP (Internal Medicine)
Royal College of Physicians , 2004.
DTM&H (Tropical Medicine)
London School of Hygiene and Tropical Medicine , 2007.
PhD (Infectious Diseases)
University of London , 2012.
MSc (Epidemiology)
London School of Hygiene and Tropical Medicine, 2014.
Post-Graduate Training
Medical Internship, University College London, Whittington Hospital, London, England, 2001-2002.
Infectious Diseases Resident, St. George's Hospital London, England, 2002-2003.
Internal Medicine Residency, Newcastle-upon-Tyne Central Hospitals, England, UK, 2003-2005.
Clinical Research Fellow (Tropical Medicine), Wellcome Clinical Center of Tropical Medicine, St. George’s Hospital, London, England, Malaria Research Unit, Gabon, Hospital Albert Schweitzer, Gabon, 2003-2003.
Specialist Registrar in Infectious Diseases / Clinical Lecturer, St. George's Hospital, London, England, 2005-2007.
Wellcome Trust Training Fellow in Clinical Tropical Medicine , Desmond Tutu HIV Center, University of Cape Town, Immunology Lab, VRC, National Institutes of Health, Bethesda, MD , 2007-2011.
Specialist Registrar in Tropical Medicine, Hospital for Tropical Diseases, London, England, 2011-2012.
Clinical Lecturer in Infectious Diseases, London School of Hygiene and Tropical Medicine, London, England, 2012-2014.
Royal College of Physicians (UK) and General Medical Council (UK). CCT Infectious Diseases, 2013.
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Description of Clinical Expertise

After completing training in general (internal) medicine and obtaining Membership of the Royal College of Physicians in June 2004 I undertook specialist training in infectious diseases and tropical medicine, gaining my CCT in infectious diseases in September 2013. I have extensive experience of managing infectious diseases in both inpatient and outpatient settings. Training in London teaching hospitals has enabled me to develop a broad range of competencies, from treating difficult MDR-TB cases and managing illness in travellers returning from the tropics to dealing with complex hospital acquired infections in intensive care settings. I have developed expertise in both the inpatient and outpatient management of HIV infection in London, and further consolidated this experience during 3 years in South Africa where I looked after inpatients with HIV-associated opportunistic infections, took part in twice weekly infectious diseases ward rounds, and ran my own HIV clinic list. I currently do a weekly HIV-treatment failure clinic in the tertiary referral centre serving Botswana, and work as an attending physician in the internal medicine service at Princess Marina Hospital, Gaborone.

Description of Research Expertise

My initial research training was at the Wellcome Clinical Centre of Tropical Medicine, St. George’s Hospital, London, in collaboration with the Malaria Research Unit, Centre Hospitalier, Libreville, Gabon and the Hopital Albert Schweitzer, Lambaréné, Gabon. I carried out a clinical research project in Gabon, Central Africa, entitled “The Pathophysiology of Lactic Acidosis in Severe Malaria”, under the supervision of Professor Sanjeev Krishna. Following this I was awarded a Wellcome Trust research training fellowship in clinical tropical medicine for a project entitled “Adjunctive IFN-γ for HIV-associated cryptococcal meningitis: effect on local and systemic immune responses and clearance of infection” under the supervision of Professor Tom Harrison. The project involved both clinical research in South Africa in collaboration with the University of Cape Town and basic immunology work at the National Institutes of Health in the United States. I have continued to pursue my research interest in cryptococcal meningitis, and have recently obtained a Gilead Investigator Initiated Award (as PI) to perform a randomized controlled trial exploring novel short course Ambisome based regimens for the treatment of HIV-associated cryptococcal meningitis. I have extensive clinical research experience including development of study protocols and other study documentation, obtaining ethics approvals, day to day running of clinical trials, data management and data analysis. I have written and published over 50 manuscripts in peer-reviewed journals, the majority high impact factor publications, most as first or senior author. I have obtained formal statistics and epidemiology training through the Intensive course in epidemiology and medical statistics at the London School of Hygiene and Tropical Medicine and the MSc in epidemiology at the LSHTM.

Selected Publications

Kadimisetty K, Song J, Doto AM, Hwang Y, Peng J, Mauk MG, Bushman FD, Gross R, Jarvis JN, Liu C: Fully 3D printed integrated reactor array for point-of-care molecular diagnostics. Biosens Bioelectron 109: 156-163, Jun 2018.

Seatla KK, Avalos A, Moyo S, Mine M, Diphoko T, Mosepele M, Gaolatlhe T, Rowley CF, Ramaabya D, Jarvis JN, Kasvosve I, Gaseitsiwe S: Four class drug resistant HIV-1 subtype C in a treatment experienced individual on dolutegravir based antiretroviral therapy in Botswana. AIDS Jun 2018.

Jarvis JN, Leeme TB, Molefi M, Chofle AA, Bidwell G, Tsholo K, Tlhako N, Mawoko N, Patel RKK, Tenforde MW, Muthoga C, Bisson GP, Kidola J, Changalucha J, Lawrence D, Jaffar S, Hope W, Molloy SlF, Harrison TS: Short Course High-dose Liposomal Amphotericin B for HIV-associated Cryptococcal Meningitis: A phase-II Randomized Controlled Trial. Clin Infect Dis Jun 2018.

Wake RM, Jarvis JN, Harrison TS, Govender NP: Point of Care Cryptococcal Antigen Screening: Pipetting Finger-Prick Blood Improves Performance of Immuno-Mycologics Lateral Flow Assay. J Acquir Immune Defic Syndr Page: Epub ahead of print, Apr 2018.

Ford N, Shubber Z, Jarvis JN, Chiller T, Greene G, Migone C, Vitoria M, Doherty M, Meintjes G: CD4 Cell Count Threshold for Cryptococcal Antigen Screening of HIV-Infected Individuals: A Systematic Review and Meta-analysis. Clin Infect Dis 66(suppl_2): S152-S159, Mar 2018.

Marukutira T, Stoové M, Lockman S, Mills LA, Gaolathe T, Lebelonyane R, Jarvis JN, Kelly SL, Wilson DP, Luchters S, Crowe SM, Hellard M: A tale of two countries: progress towards UNAIDS 90-90-90 targets in Botswana and Australia. J Int AIDS Soc 21(3), Mar 2018.

Wake RM, Britz E, Sriruttan C, Rukasha I, Omar T, Spencer DC, Nel JS, Mashamaite S, Adelekan A, Chiller TM, Jarvis JN, Harrison TS, Govender NP: High Cryptococcal Antigen Titers in Blood Are Predictive of Subclinical Cryptococcal Meningitis Among Human Immunodeficiency Virus-Infected Patients. Clin Infect Dis 66(5): 686-692, Feb 2018.

Goldberg DW, Tenforde MW, Mitchell HK, Jarvis JN: Neurological Sequelae of Adult Meningitis in Africa: A Systematic Literature Review. Open Forum Infect Dis 5(1): ofx246, Jan 2018.

Scriven JE, Tenforde MW, Levitz SM, Jarvis JN: Modulating host immune responses to fight invasive fungal infections. Curr Opin Microbiol 40: 95-103, Dec 2017.

Tenforde MW, Mokomane M, Leeme T, Patel RKK, Lekwape N, Ramodimoosi C, Dube B, Williams EA, Mokobela KO, Tawanana E, Pilatwe T, Hurt WJ, Mitchell H, Banda DL, Stone H, Molefi M, Mokgacha K, Phillips H, Mullan PC, Steenhoff AP, Mashalla Y, Mine M, Jarvis JN: Advanced Human Immunodeficiency Virus Disease in Botswana Following Successful Antiretroviral Therapy Rollout: Incidence of and Temporal Trends in Cryptococcal Meningitis. Clin Infect Dis 65(5): 779-786, Sep 2017.

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Last updated: 08/01/2018
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