Angela M DeMichele, MD, MSCE, FASCO
Mariann T. and Robert J. MacDonald Professor in Breast Cancer Care Excellence
Department: Medicine
Contact information
Division of Hematology Oncology
Perelman Center for Advanced Medicine
10th Floor, South Pavilion
Office #10-153
3400 Civic Center Boulevard
Philadelphia, PA 19104
Perelman Center for Advanced Medicine
10th Floor, South Pavilion
Office #10-153
3400 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-349-5730
Fax: 215-615-3349
Fax: 215-615-3349
Education:
B.A. (Biochemistry)
Brown University, 1988.
M.D. (Medicine)
Washington University School of Medicine, 1991.
M.S.C.E. (Clinical Epidemiology)
University of Pennsylvania, School of Medicine, 2001.
Permanent linkB.A. (Biochemistry)
Brown University, 1988.
M.D. (Medicine)
Washington University School of Medicine, 1991.
M.S.C.E. (Clinical Epidemiology)
University of Pennsylvania, School of Medicine, 2001.
Selected Publications
Mukhtar, R. A., Dimitroff, K., Yau, C., Chien, A. J., Connolly, E. P., Howard-McNatt, M., Rao, R., Ladores, V., Golshan, M., Sauder, C. A., Ahmed, K., Lancaster, R., Fox, J., Gutnik, L., Lee, M. C., Tchou, J., Prionas, N., Arciero, C. A., Reyna, C., Kuerer, H., Switalla, K., Taunk, N., Tuttle, T. M., Moran, M. S., Postlewait, L. M., Perlmutter, J., DeMichele, A., Yee, D., Hylton, N., Symmans, W. F., Rugo, H. S., Shatsky, R., Isaacs, C., Esserman, L. J., Van't Veer, L., Boughey, J. C.: Impact of Neoadjuvant Chemotherapy on Surgical Outcomes and Conversion to Node-Negativity in Invasive Lobular Breast Cancer: Analysis of Molecularly High-Risk Tumors by Histologic Subtype on the I-SPY2 Clinical Trial. Annals of surgical oncology Jul 2025.Villacampa, G., Pascual, T., Tarantino, P., Cortés, J., Perez-García, J., Llombart-Cussac, A., Conte, P., Mancino, M., Guarneri, V., Dieci, M. V., Waks, A. G., Schettini, F., Brasó-Maristany, F., Griguolo, G., de Castro, B. A., Reboredo, C., Antolín, S., Bueno-Muiño, C., Echavarría, I., López-Tarruella, S., Massarrah, T., Monte-Millán, M. D., Martin, M., Buckingham, W., Parker, J. S., Vivancos, A., Polyak, K., Filho, O. M., Wolff, A. C., DeMichele, A., Tung, N. M., Perou, C. M., Paré, L., Villagrasa, P., Prat, A., Tolaney, S. M.: HER2DX and survival outcomes in early-stage HER2-positive breast cancer: an individual patient-level meta-analysis Lancet Oncology Jul 2025.
Kaur, M., Dimitroff, K., Boughey, J. C., Esserman, L. J., Yau, C., Tchou, J., Quirarte, A., Lee, M. C., Howard-McNatt, M. M., Switalla, K., Kuerer, H., Sauder, C., Postlewait, L. M., Arciero, C., Rao, R., Wallace, A., Reyna, C., Ahmed, K., Gutnik, L., Taunk, N., Perlmutter, J., DeMichele, A., Yee, D., Yee, D., Hylton, N., Symmans, W. F., Rugo, H. S., Shatsky, R., Isaacs, C., Rudra, S., Pohlmann, P., Ewing, C., Wong, J., Alvarado, M., Jaskowiak, N., Prionas, N., Golshan, M., Piltin, M. A., Olopade, O. I., Mukhtar, R. A.: Disparities in the Surgical Management of the Axilla by Self-Identified Race in the Multicenter Neoadjuvant I-SPY2 Trial Annals of surgical oncology Jul 2025.
Shinn, E., Zahrieh, D., DeMichele, A., Zdenkowski, N., Lemieux, J., Mao, J., Bjelic-Radisic, V., Naughton, M. J., Pfeiler, G., Gelmon, K., Balko, J. M., Egle, D., Zoppoli, G., Traina, T., Jimenez, M. M., Novoa, S. A., Haddad, T., Chan, A., Ring, A., Wolff, A.,Symanns, W. F., Lorenzo, J. P., Sabanatha, D., Burstein. H. J., Bellet-Ezquerra, M., Foukakis, T., Novik, Y., Rubovszky, G., Singer, C. F., Muehlbacher, K., Filho, O. M., Goulioti, T., Law, E., Partridge, A. H., Carey, L. A., Zoroufy, A., Hlauschek, D., Fesl, C., Mayer, E. L., Gnant, M.: Impact of adding palbociclib on treatment adherence to ongoing adjuvant endocrine treatment in the global randomized PALLAS randomized trial in patients with early breast cancer. Breast Cancer Res Treat Jun 2025.
Wolf, D. M., Yau, C., Campbell, M., Glas, A., Barcaru, A., Mittempergher, L., Kuilman, M., Brown-Swigart, L., Hirst, G., Basu, A., Magbanua, M., Sayaman, R., Huppert, L., Delson, A., I-SPY2 Investigators, Symmans, W. F., Borowsky, A., Pohlmann, P., Rugo, H., Clark, A., Yee, D., DeMichele, A., Perlmutter, J., Petricoin, E. F., Chein, J., Stringer-Reasor, E., Shatsky, R., Liu, M., Han, H., Soliman, H., Isaacs, C., Nanda, R., Hylton, N., Pusztai, L., Esserman, L., van 't Veer, L.: Immune Subtyping Identifies Patients With Hormone Receptor-Positive Early-Stage Breast Cancer Who Respond to Neoadjuvant Immunotherapy (IO): Results From Five IO Arms of the I-SPY2 Trial JCO Precis Oncol Jun 2025.
Hahnen, E., Hauke, J., Gelmon, K., Marmé, F., Ernst, C., Martin, M., Untch, M., Bonnefoi, H., Knudsen, E., Im, S.-A., DeMichele, A., Van’t Veer, L., Kim, S.-B., Bear, H., McCarthy, N., Rhiem, K., Turner, N., Witkiewicz, A., Rojo, F.,Filipits, M., Martin, LA., Fasching, P. A., Schem, C., Becker, K., García-Sáenz, J. A., Kelly, C. M., Reimer, T., Toi, M., Rugo, H. S., Denkert, C., Gnant, M., Makris, A., Liu, Y., Valota, O., Felder, B., Weber, K., Nekljudova, V., Loibl, S. : BRCA1/2 and Other Predisposition Genes in High-Risk Hormone Receptor+/Human Epidermal Growth Factor Receptor 2- Breast Cancer Treated With Endocrine Therapy With or Without Palbociclib: A Secondary PENELOPE-B Study Analysis. JCO Precision Oncology Apr 2025.
Thomas, A., Mayer, E. L., DeMichele, A., Harbeck, N., Curigliano, G., Ignatiadis, M., Adam, V., Zhou, Y., Brown, T. P., Gilham, L., Chua, B. H., Kalinsky, K., Wolff, A. C., & O'Reilly, S.: Further Optimizing Care of Patients With Operable Hormone Receptor-Sensitive Breast Cancer J Clin Oncol Feb 2025.
Huppert, L. A., Wolf, D., Yau, C., Brown-Swigart, L., Hirst, G. L., Isaacs, C., Pusztai, L., Pohlmann, P. R., DeMichele, A., Shatsky, R., Yee, D., Thomas, A., Nanda, R., Perlmutter, J., Heditsian, D., Hylton, N., Symmans, F., Van't Veer, L. J., Esserman, L., & Rugo, H. S. : Pathologic complete response (pCR) rates for patients with HR+/HER2- high-risk, early-stage breast cancer (EBC) by clinical and molecular features in the phase II I-SPY2 clinical trial. Annals of Oncology Feb 2025 Notes: https://doi.org/10.1016/j.annonc.2024.10.018.
Li, W., Onishi, N., Gibbs, J. E., Wilmes, L. J., Le, N. N., Metanat, P., Price, E. R., Joe, B. N., Kornak, J., Yau, C., Wolf, D. M., Magbanua, M. J. M., LeStage, B., van 't Veer, L. J., DeMichele, A. M., Esserman, L. J., & Hylton, N. M. : MRI-Based Model for Personalizing Neoadjuvant Treatment in Breast Cancer Tomography Feb 2025.
Mukhtar, R. A., Gottipati, S., Yau, C., López-Tarruella, S., Earl, H., Hayward, L., Hiller, L., Osdoit, M., van der Noordaa, M., de Croze, D., Hamy, A. S., Laé, M., Reyal, F., Sonke, G. S., Steenbruggen, T. G., van Seijen, M., Wesseling, J., Martín, M., Del Monte-Millán, M., Boughey, J. C.,Goetz, M. P., Hoskin, T., Valero, V. Edge, S. B., Abraham, J. E., Bartlett, J. M. S., Caldas, C., Dunn, J., Provenzano, E., Sammut, S. J., Thomas, J. S., Graham, A., Hall, P., Mackintosh, L., Fan, F., Godwin, A. K., Schwensen, K., Sharma, P., DeMichele, A. M., Cole, K., Pusztai, L., Kim, M., van 't Veer, L. J., Cameron, D., Laura J Esserman, L. J., Fraser Symmans, W.: A pooled analysis evaluating prognostic significance of Residual Cancer Burden in invasive lobular breast cancer NPJ Breast Cancer Feb 2025.