faculty photo

James D. Lewis, MD, MSCE

Professor of Medicine (Gastroenterology)
Department: Medicine

Contact information
University of Pennsylvania
Division of Gastroenterology
Center for Clinical Epidemiology and Biostatistics
423 Guardian Drive
720 Blockley Hall
Philadelphia, PA 19104-6021
Office: (215) 573-5137
Fax: (215) 573-0813
BA (Interdisciplinary Studies)
University of Virginia, 1987.
University of Pennsylvania, 1991.
MSCE (Clinical Epidemiology)
University of Pennsylvania, 1998.
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Selected Publications

Lewis James D, Scott Frank I, Brensinger Colleen M, Roy Jason A, Osterman Mark T, Mamtani Ronac, Bewtra Meenakshi, Chen Lang, Yun Huifeng, Xie Fenglong, Curtis Jeffrey R: Increased Mortality Rates With Prolonged Corticosteroid Therapy When Compared With Antitumor Necrosis Factor-α-Directed Therapy for Inflammatory Bowel Disease. The American journal of gastroenterology 113(3): 405-417, Mar 2018.

Khan Nabeel, Lee Helen, Trivedi Chinmay, Kavani Himanshu, Medvedeva Elina, Xie Dawei, Lewis James D, Yang Yu-Xiao: Mortality Associated With Development of Squamous Cell Cancer in Patients With Inflammatory Bowel Disease Receiving Treatment With Thiopurines. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 17(11): 2262-2268, Mar 2019.

Albenberg L, Brensinger C M, Wu Q, Gilroy E, Kappelman M D, Sandler R S, Lewis J D: A Diet Low in Red and Processed Meat Does Not Reduce Rate of Crohn's Disease Flares. Gastroenterology 157(1): 128-136.e5, Mar 2019.

Scott, F. I., Hans, A. K., Gerich, M. E., Fennimore, B., Mamtani, R., Vajravelu, R. K., Lewis, J. D.: Identification of the Most Effective Position for Ustekinumab in Treatment Algorithms for Crohn''s Disease. Clin Gastroenterol Hepatol 2020.

Scott, F. I., Luo, M., Shah, Y., Lasch, K., Vajravelu, R. K., Mamtani, R., Fennimore, B., Gerich, M. E., Lewis, J. D.: Identification of the Most Cost-effective Position of Vedolizumab Among the Available Biologic Drugs for the Treatment of Ulcerative Colitis. J Crohns Colitis 14(5): 575-587, Jun 2020.

Tanes C, Bittinger K, Gao Y, Friedman ES, Nessel L, Paladhi UR, Chau L, Panfen E, Fischbach MA, Braun J, Xavier RJ, Clish CB, Li H, Bushman FD, Lewis JD, Wu GD.: Role of dietary fiber in the recovery of the human gut microbiome and its metabolome. Cell Host Microbe ell Host Microbe: 394-407, Mar 2021.

Lewis JD, Sandler R, Brotherton C, Brensinger C, Li H, Kappelman MD, Daniel SG, Bittinger K, Albenberg L, Valentine JF, Hanson J, Suskind D, Meyer A, Compher CW, Bewtra M, Saxena A, Dobes A, Cohen B, Flynn AD, Fischer M, Saha S, Swaminath A, Yacyshyn B, Scherl E, Horst S, Curtis JR, Braly K, Nessel L, McCauley M, McKeever L, Herfarth H; DINE-CD Study Group.: A Randomized Trial Comparing the Specific Carbohydrate Diet to a Mediterranean Diet in Adults With Crohn's Disease. Gastroenterology May 2021.

Raffals LE, Saha S, Bewtra M, Norris C, Dobes A, Heller C, O'Charoen S, Fehlmann T, Sweeney S, Weaver A, Bishu S, Cross R, Dassopoulos T, Fischer M, Yarur A, Hudesman D, Parakkal D, Duerr R, Caldera F, Korzenik J, Pekow J, Wells K, Bohm M, Perera L, Kaur M, Ciorba M, Snapper S, Scoville EA, Dalal S, Wong U, Lewis JD.: The Development and Initial Findings of A Study of a Prospective Adult Research Cohort with Inflammatory Bowel Disease (SPARC IBD). Inflamm Bowel Dis 28: 192-199, Aug 2021.

Chassaing B, Compher C, Bonhomme B, Liu Q, Tian Y, Walters W, Nessel L, Delaroque C, Hao F, Gershuni V, Chau L, Ni J, Bewtra M, Albenberg L, Bretin A, McKeever L, Ley RE, Patterson AD, Wu GD, Gewirtz AT, Lewis JD.: Randomized controlled-feeding study of dietary emulsifier carboxymethylcellulose reveals detrimental impacts on the gut microbiota and metabolome. Gastroenterology Nov 2021.

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Last updated: 01/28/2024
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