Molecular mechanisms of insulin signaling and insulin resistance
metabolism, insulin, diabetes, obesity, Akt
My research interests are focused on the regulation of metabolism by hormones and nutrients, with a particular emphasis on a master regulator of organismal anabolic metabolism, insulin. Alterations in insulin action underlie metabolic disease and lead to the development of deadly vascular and neuronal complications. Through the use of various techniques encompassing molecular biology, biochemistry, metabolomics, genome-wide transcriptional techniques and whole-animal physiology, the long-term goals of my research program are to decipher the underlying mechanisms driving metabolic deregulation during disease and identify new therapies that improve metabolic control.
Matthew Gavin (Research Specialist)
Natasha Jaiswal Ph.D. (Postdoctoral Researcher)
Kahea Uehara (PhD student, BMB graduate group)
Jaimarie Sostre (PhD student, CAMB graduate group)
Dominic Santoleri (PhD student, BMB graduate group)
Anna Garcia Whitlock M.D. (PhD student, CAMB graduate group)
Shen Yachen, Su Yvonne, Silva Francisco J, Weller Angela H, Sostre-Colón Jaimarie, Titchenell Paul M, Steger David J, Seale Patrick, Soccio Raymond E: Shared PPARα/γ Target Genes Regulate Brown Adipocyte Thermogenic Function. Cell reports 30(9): 3079-3091.e5, Mar 2020.
Zhao Steven, Jang Cholsoon, Liu Joyce, Uehara Kahealani, Gilbert Michael, Izzo Luke, Zeng Xianfeng, Trefely Sophie, Fernandez Sully, Carrer Alessandro, Miller Katelyn D, Schug Zachary T, Snyder Nathaniel W, Gade Terence P, Titchenell Paul M, Rabinowitz Joshua D, Wellen Kathryn E: Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate. Nature 579(7800): 586-591, Mar 2020.
Garcia Whitlock Anna E, Titchenell Paul M: Glutamine Breakdown as a Potential Metabolic Biomarker for Nonalcoholic Steatohepatitis. Cellular and molecular gastroenterology and hepatology Mar 2020.
Angueira Anthony R, Shapira Suzanne N, Ishibashi Jeff, Sampat Samay, Sostre-Colón Jaimarie, Emmett Matthew J, Titchenell Paul M, Lazar Mitchell A, Lim Hee-Woong, Seale Patrick: Early B Cell Factor Activity Controls Developmental and Adaptive Thermogenic Gene Programming in Adipocytes. Cell reports 30(9): 2869-2878.e4, Mar 2020.
Jaiswal N, Gavin M G, Quinn W J, Luongo T S, Gelfer R G, Baur J A, Titchenell P M: The role of skeletal muscle Akt in the regulation of muscle mass and glucose homeostasis. Molecular metabolism 28: 1-13, Aug 2019 Notes: Selected as the cover for October 2019 issue.
Ahn Byungyong, Wan Shibiao, Jaiswal Natasha, Vega Rick B, Ayer Donald E, Titchenell Paul M, Han Xianlin, Won Kyoung Jae, Kelly Daniel P: MondoA drives muscle lipid accumulation and insulin resistance. JCI insight 5, Jul 2019.
Santoleri Dominic, Titchenell Paul M: Resolving the Paradox of Hepatic Insulin Resistance. Cellular and molecular gastroenterology and hepatology 7(2): 447-456, 2019.
Lin Cheng-Mao* (co-first author), Titchenell Paul M* (co-first author), Keil Jason M, Garcia-Ocaña Adolfo, Bolinger Mark T, Abcouwer Steven F, Antonetti David A: Inhibition of Atypical Protein Kinase C Reduces Inflammation-Induced Retinal Vascular Permeability. The American journal of pathology 188(10): 2392-2405, Oct 2018.
Quinn William J, Wan Min, Shewale Swapnil V, Gelfer Rebecca, Rader Daniel J, Birnbaum Morris J, Titchenell Paul M: mTORC1 stimulates phosphatidylcholine synthesis to promote triglyceride secretion. The Journal of clinical investigation 127(11): 4207-4215, Nov 2017.
Titchenell Paul M, Lazar Mitchell A, Birnbaum Morris J: Unraveling the Regulation of Hepatic Metabolism by Insulin. Trends in endocrinology and metabolism: TEM 28(7): 497-505, Apr 2017.
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Last updated: 06/23/2020
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