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Peter F. Davies, Ph.D., Sc.D.

Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
1010 Vagelos Research Lab
3340 Smith Walk
Philadelphia, PA 19104-6383
Office: (215) 573-6813
Fax: (215) 573-6815
Education:
B.Sc. (Chemistry/Ag. Biochemistry (w/Hons.))
University of Newcastle-upon-Tyne, 1969.
M.Sc. (Biochemistry)
University of Victoria, B.C., Canada, 1972.
Ph.D. (Experimental Pathology)
University of Cambridge, 1975.
M.A. (Honoris causa)
University of Pennsylvania, 1996.
Sc.D. (Higher Doctorate)
University of Cambridge, 2015.
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Description of CVI Expertise

CVI Program Unit Administrator:
Biotechnology / Nanomedicine / Imaging

Research Interests
Biomechanics in Vascular Biology/Pathology, Hemodynamics and Atherosclerosis, Vascular Cell Communication, Cytoskeletal and membrane biophysics.

Key Words: Endothelium, hemodynamic forces, atherosclerosis, vascular biology, vascular pathology, endothelial mechanotransduction, shear stress, endothelial genomics.

Description of Research
Molecular mechanisms of cardiovascular diseases, particularly arterial biology and pathology (atherosclerosis). Mechanisms of interaction of hemodynamic forces with the vascular endothelium and vascular cell-cell interactions. Experimental approaches ranging from cell and molecular biology, membrane biophysics, to biomechanics andcomputational fluid dynamics.

Rotation Projects for 2003-2004
Please discuss with Dr. Davies.

Lab Personnel:
Tony Passerini PhD, Postdoctoral Fellow
David Kaufman MD, Postdoctoral Fellow
Craig Simmons PhD, Postdoctoral Fellow
Jon Lakins PhD, Postdoctoral Fellow
Jenny Zilberberg PhD, Postdoctoral Fellow
Richard Magid PhD, Postdoctoral Fellow
Mete Civelek, Graduate Student
Yun Fang, Graduate Student
Technical Staff: Congzhu Shi PhD, Technical Staff
Nadeene Francesco, Technical Staff
Rebecca Riley, Technical Staff
Richard Kim, Student Intern
Gary Chang, Student Intern
Tran Lo, Student Intern
Justyna Mach, Student Intern
Matthew Henry, Student Intern

Selected Publications

Davies P.F.: In: LabStudio: Design Research Between Architecture & Biology. Sabin J and Jones P. Pub: Routledge / Taylor and Francis (2016). In Press. Routledge / Taylor and Francis In Press(In Press), In Press 2016.

McCormick ME, Manduchi E, Witschey WRT, Gorman RC, Gorman JH 3rd, Jiang Y-Z, Barker AJ, Markl M, Stoeckert CJ, Davies PF.: Integrated regional cardiac hemodynamic imaging and RNA sequencing reveals corresponding heterogeneity of ventricular wall shear stress and the endocardial transcriptome. J Am Heart Assoc In Press, In Press 2016.

Sweet DT, Jiménez JM, Chang J, Hess PR, Mericko-Ishizuka P, Fu J, Xia L, Davies PF, Kahn ML.: Lymph flow regulates collecting lymphatic vessel maturation in vivo. J. Clin Invest. 125: 2995-3007, August 2015.

Han J, Shuvaev VV, Davies PF, Eckmann DM, Muro S, Muzykantov VR. : Flow shear stress differentially regulates endothelial uptake of nanocarriers targeted to distinct epitopes of PECAM-1. J Controlled Release 210: 39-47, July 2015.

Jiang, Y-Z, Manduchi, E, Stoeckert CJ, Davies PF.: Arterial endothelial methylome: Differential DNA methylation in athero-susceptible disturbed flow regions in vivo. BMC Genomics 16: 506, July 2015.

Chacko A-M, Han J, Zern BJ, Greineder C, Mikitsch JL, Nayak M, Menon D, Poncz M, Johnston I, Eckman D, Davies PF, Muzykantov VR. : Collaborative enhancement of endothelial nanocarrier targeting by modulating PECAM-1/CD31 epitope engagement. Am. Chem. Soc. Nano. 9(7): 6785-6793, July 2015.

Jiang Y-Z, Manduchi E, Jimenez JM, Davies PF. : Endothelial epigenetics in biomechanical stress: Disturbed flow-mediated epigenomic plasticity in vivo and in vitro. Arterioscler Thromb Vasc Biol 35: 1317-1326, June 2015.

Kwak, B., Back M., Bochaton-Piallat, M.L., Caligiuri, G., Daemen, M., Davies, P.F., Hoefer, I., Holvoet, P., Krams, R., Monaco, C., Virmani, R., Weber, C., Wentzel Y., Evans, P.: Biomechanical factors in atherosclerosis - Mechanisms and implications. European Heart Journal. European Society Cardiology, 35(43): 3013-3020, Sept 2014.

Jiang YZ, Jiménez JM, Ou K, McCormick ME, Zhang LD, Davies PF.: Hemodynamic disturbed flow induces differential DNA methylation of endothelial kruppel-like factor 4 promoter in vitro and in vivo. Circulation Research 115:((1)): 32-43, June 2014.

Davies PF, Manduchi E, Stoeckert CJ, Jimenez JM, Jiang, Y-Z : Emerging topic: Flow-related epigenetic regulation of endothelial phenotype through DNA methylation. Vascular Pharmacology 62: 88-93, March 2014.

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Last updated: 03/22/2016
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