Peter F. Davies

faculty photo
Professor of Pathology and Laboratory Medicine
Co-Director, Research Program in Biotechnology, Cardiovascular Research Institute
Member, and Advisory Board Member, Institute for Translational Medicine and Therapeutics
Co-Director, HHMI-NIBIB Graduate Program in Biomedical Imaging and Informational Sciences
Department: Pathology and Laboratory Medicine

Contact information
1010 Vagelos Research Lab
3340 Smith Walk
Philadelphia, PA 19104-6383
Office: (215) 573-6813
Fax: (215) 573-6815
Graduate Group Affiliations
Education:
BSc. (Chemistry/Biochemistry (w/Hons.))
University of Newcastle-upon-Tyne, UK, 1969.
MSc. (Biochemistry)
University of Victoria, B.C., Canada, 1972.
Ph.D. (Experimental Pathology)
Cambridge University, UK, 1975.
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Description of Research Expertise

CVI Program Unit Administrator:
Biotechnology / Nanomedicine / Imaging

Research Interests
Biomechanics in Vascular Biology/Pathology, Hemodynamics and Atherosclerosis, Stents, Cytoskeletal and membrane biophysics.

Key Words: Endothelium, hemodynamic forces, atherosclerosis, vascular biology, vascular pathology, endothelial mechanotransduction, shear stress, endothelial genomics.

Description of Research
Molecular mechanisms of cardiovascular diseases, particularly arterial biology and pathology (atherosclerosis). Mechanisms of interaction of hemodynamic forces with the vascular endothelium and vascular cell-cell interactions. Experimental approaches ranging from cell and molecular biology, membrane biophysics, to biomechanics andcomputational fluid dynamics. Stent design.

Rotation Projects
Please discuss with Dr. Davies.

Lab Personnel:
Juan Jimenez PhD, Postdoctoral Fellow
Armen Karamanian MD, Graduate Student
Mete Civelek PhD, Postdoctoral Fellow
Yun Fang PhD, Postdoctoral Fellow
Jennifer Clark PhD, Postdoctoral Fellow
Technical Staff: Congzhu Shi PhD, Technical Staff

Description of Other Expertise

Biophysics; Lipid metabolism

Description of Itmat Expertise

Dr. Davies is interested in quantitative aspects of vascular pathophysiology especially the influence of hemodynamics.

Selected Publications

Jiang Y-Z, Zhang L-D, Manduchi E, Davies PF. : Oxidative stress induces DNA hypermethylation of endothelial HOXA5 promoter and gene suppression in vitro and maps to athero-susceptible endothelium in vivo. Circulation Research In preparation 2016.

Karamanian, A., Jimenez, J.M.,Jiang Y-Z, Davies, P.F. : Loss of flow-sensitive endothelial Claudin-5 expression at atherosusceptibility sites in vivo. Circulation Research In preparation 2016.

Han J, Shuvaev VV, Davies PF, Eckmann DM, Muro S, Muzykantov VR. : Flow shear stress differentially regulates endothelial uptake of nanocarriers targeted to distinct epitopes of PECAM-1. J Controlled Release 210: 39-47, July (ePub May) 2015.

Jiang Y-Z, Manduchi E, Jimenez JM, Davies PF. : Endothelial epigenetics in biomechanical stress: Disturbed flow-mediated epigenomic plasticity in vivo and in vitro. Arterioscler Thromb Vasc Biol 35: 1317-1326, June 2015.

Chacko A-M, Han J, Zern BJ, Greineder C, Mikitsch JL, Nayak M, Menon D, Poncz M, Johnston I, Eckman D, Davies PF, Muzykantov VR. : Collaborative enhancement of endothelial nanocarrier targeting by modulating PECAM-1/CD31 epitope engagement. Am. Chem. Soc. Nano. ePub July 2015.

Jiang, Y-Z, Manduchi, E, Stoeckert CJ, Davies PF.: Arterial endothelial methylome: Differential DNA methylation in athero-susceptible disturbed flow regions in vivo. BMC Genomics ePub July 2015.

Sweet DT, Jiménez JM, Chang J, Hess PR, Mericko-Ishizuka P, Fu J, Xia L, Davies PF, Kahn ML.: Lymph flow regulates collecting lymphatic vessel maturation in vivo. J. Clin Invest. In Press 2015.

Kwak, B., Back M., Bochaton-Piallat, M.L., Caligiuri, G., Daemen, M., Davies, P.F., Hoefer, I., Holvoet, P., Krams, R., Monaco, C., Virmani, R., Weber, C., Wentzel Y., Evans, P.: Biomechanical factors in atherosclerosis - Mechanisms and implications. European Heart Journal doi: 10.1093 eurheartj/ehu353 in press. European Society Cardiology, In Press, Sept 2014.

Jiang YZ, Jiménez JM, Ou K, McCormick ME, Zhang LD, Davies PF.: Hemodynamic disturbed flow induces differential DNA methylation of endothelial kruppel-like factor 4 promoter in vitro and in vivo. Circulation Research 115:((1)): 32-43, June 2014.

Davies PF, Manduchi E, Stoeckert CJ, Jimenez JM, Jiang, Y-Z : Emerging topic: Flow-related epigenetic regulation of endothelial phenotype through DNA methylation. Vascular Pharmacology 62: 88-93, March 2014.

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Last updated: 07/13/2015
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