Susan W Volk
Corinne R. and Henry Bower Professor of Surgery, University of Pennsylvania, School of Veterinary Medicine
Graduate Group Affiliations
Contact information
Section of Surgery
Department of Clinical Studies - Philadelphia
University of Pennsylvania School of Veterinary Medicine
312 Hill Pavilion
380 S. University Ave
Philadelphia, PA 19104-4539
Department of Clinical Studies - Philadelphia
University of Pennsylvania School of Veterinary Medicine
312 Hill Pavilion
380 S. University Ave
Philadelphia, PA 19104-4539
Office: 215-898-0635
Fax: 215-573-6050
Fax: 215-573-6050
Email:
swvolk@vet.upenn.edu
swvolk@vet.upenn.edu
Publications
Education:
B.A.
University of Pennsylvania College of Arts and Sciences, 1991.
V.M.D.
University of Pennsylvania, 1995.
Ph.D.
University of Pennsylvania, 1998.
B.A.
University of Pennsylvania College of Arts and Sciences, 1991.
V.M.D.
University of Pennsylvania, 1995.
Ph.D.
University of Pennsylvania, 1998.
Post-Graduate Training
Post-Doctoral Researcher , Department of Biochemistry, School of Dental Medicine University of Pennsylvania, Philadelphia, PA , 1998-1999.
Rotating Intern, School of Veterinary Medicine, University of Pennsylvania Philadelphia, PA, 1999-2000.
Resident, School of Veterinary Medicine, University of Pennsylvania Philadelphia, PA , 2000-2003.
Permanent linkPost-Doctoral Researcher , Department of Biochemistry, School of Dental Medicine University of Pennsylvania, Philadelphia, PA , 1998-1999.
Rotating Intern, School of Veterinary Medicine, University of Pennsylvania Philadelphia, PA, 1999-2000.
Resident, School of Veterinary Medicine, University of Pennsylvania Philadelphia, PA , 2000-2003.
Description of Research Expertise
The goals of the Volk laboratory are to understand regulatory mechanisms governing dynamic interactions between cells and their surrounding extracellular matrix in the wound healing-fibrosis-cancer progression triad and to apply this knowledge to develop innovative regenerative and oncologic therapies for veterinary and human patients.Description of Itmat Expertise
The research interests of my laboratory focus on defining regulatory cues important to direct progenitor cell homing to sites of injury, as well as, in vitro and in vivo signals important to direct their differentiation into appropriate target cell types for use in tissue engineering strategies in human and veterinary medicine. Current work focuses on defining cellular and molecular mechanisms by which mesenchymal progenitor cells improve cutaneous wound repair and elucidating the role of the extracellular matrix in modulation of reparative and progenitor cell activities during tissue repair and regeneration.Selected Publications
Ortiz Angelica, Gui Jun, Zahedi Farima, Yu Pengfei, Cho Christina, Bhattacharya Sabyasachi, Carbone Christopher J, Yu Qiujing, Katlinski Kanstantsin V, Katlinskaya Yuliya V, Handa Simran, Haas Victor, Volk Susan W, Brice Angela K, Wals Kim, Matheson Nicholas J, Antrobus Robin, Ludwig Sonja, Whiteside Theresa L, Sander Cindy, Tarhini Ahmad A, Kirkwood John M, Lehner Paul J, Guo Wei, Rui Hallgeir, Minn Andy J, Koumenis Constantinos, Diehl J Alan, Fuchs Serge Y: An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles. Cancer cell 35(1): 33-45.e6, Jan 2019.Garden O A, Volk S W, Mason N J, Perry J A: Companion animals in comparative oncology: One Medicine in action. Veterinary journal (London, England : 1997) 240: 6-13, Oct 2018.
Raposo-Ferreira Talita M M, Brisson Becky K, Durham Amy C, Laufer-Amorim Renee, Kristiansen Veronica, Puré Ellen, Volk Susan W, Sorenmo Karin: Characteristics of the Epithelial-Mesenchymal Transition in Primary and Paired Metastatic Canine Mammary Carcinomas. Veterinary pathology 55(5): 622-633, 09 2018.
Case Ashley, Brisson Becky K, Durham Amy C, Rosen Suzanne, Monslow James, Buza Elizabeth, Salah Pascale, Gillem Julie, Ruthel Gordon, Veluvolu Sridhar, Kristiansen Veronica, Puré Ellen, Brown Dorothy C, Sørenmo Karin U, Volk Susan W: Identification of prognostic collagen signatures and potential therapeutic stromal targets in canine mammary gland carcinoma. PloS one 12(7): e0180448, 2017.
Sebastian Anil, Volk Susan W, Halai Poonam, Colthurst James, Paus Ralf, Bayat Ardeshir: Enhanced Neurogenic Biomarker Expression and Reinnervation in Human Acute Skin Wounds Treated by Electrical Stimulation. The Journal of investigative dermatology 137(3): 737-747, 03 2017.
Glennie Nelson D, Volk Susan W, Scott Phillip: Skin-resident CD4+ T cells protect against Leishmania major by recruiting and activating inflammatory monocytes. PLoS pathogens 13(4): e1006349, Apr 2017.
Rak Gregory D, Osborne Lisa C, Siracusa Mark C, Kim Brian S, Wang Kelvin, Bayat Ardeshir, Artis David, Volk Susan W: IL-33-Dependent Group 2 Innate Lymphoid Cells Promote Cutaneous Wound Healing. The Journal of investigative dermatology 136(2): 487-96, Feb 2016.
Han Ziying, Bart Stephen M, Ruthel Gordon, Vande Burgt Nathan H, Haines Kathleen M, Volk Susan W, Vite Charles H, Freedman Bruce D, Bates Paul, Harty Ronald N: Ebola virus mediated infectivity is restricted in canine and feline cells. Veterinary microbiology 182: 102-7, Jan 2016.
Shen Yu-I, Song Hyun-Ho G, Papa Arianne E, Burke Jacqueline A, Volk Susan W, Gerecht Sharon: Acellular Hydrogels for Regenerative Burn Wound Healing: Translation from a Porcine Model. The Journal of investigative dermatology 135(10): 2519-29, Oct 2015.
Sebastian Anil, Iqbal Syed A, Colthurst James, Volk Susan W, Bayat Ardeshir: Electrical stimulation enhances epidermal proliferation in human cutaneous wounds by modulating p53-SIVA1 interaction. The Journal of investigative dermatology 135(4): 1166-74, Apr 2015.
Miedel Emily L, Brisson Becky K, Hamilton Todd, Gleason Hadley, Swain Gary P, Lopas Luke, Dopkin Derek, Perosky Joseph E, Kozloff Kenneth M, Hankenson Kurt D, Volk Susan W: Type III collagen modulates fracture callus bone formation and early remodeling. Journal of orthopaedic research : official publication of the Orthopaedic Research Society 33(5): 675-84, May 2015.
Brisson Becky K, Mauldin Elizabeth A, Lei Weiwei, Vogel Laurie K, Power Ashley M, Lo Albert, Dopkin Derek, Khanna Chand, Wells Rebecca G, Puré Ellen, Volk Susan W: Type III Collagen Directs Stromal Organization and Limits Metastasis in a Murine Model of Breast Cancer. The American journal of pathology 185(5): 1471-86, May 2015.
Glennie Nelson D, Yeramilli Venkata A, Beiting Daniel P, Volk Susan W, Weaver Casey T, Scott Phillip: Skin-resident memory CD4+ T cells enhance protection against Leishmania major infection. The Journal of experimental medicine 212(9): 1405-14, Aug 2015.
Wormser C, Mariano A, Holmes E S, Aronson L R, Volk S W: Post-transplant malignant neoplasia associated with cyclosporine-based immunotherapy: prevalence, risk factors and survival in feline renal transplant recipients. Veterinary and comparative oncology Oct 2014.
Volk Susan W, Shah Shalin R, Cohen Arthur J, Wang Yanjian, Brisson Becky K, Vogel Laurie K, Hankenson Kurt D, Adams Sherrill L: Type III collagen regulates osteoblastogenesis and the quantity of trabecular bone. Calcified tissue international 94(6): 621-31, Jun 2014.
Ud-Din Sara, Volk Susan W, Bayat Ardeshir: Regenerative healing, scar-free healing and scar formation across the species: current concepts and future perspectives. Experimental dermatology 23(9): 615-9, Sep 2014.
Volk Susan W, Iqbal Syed Amir, Bayat Ardeshir: Interactions of the Extracellular Matrix and Progenitor Cells in Cutaneous Wound Healing. Advances in wound care 2(6): 261-272, Jul 2013.
Volk Susan W, Theoret Christine: Translating stem cell therapies: the role of companion animals in regenerative medicine. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 21(3): 382-94, May-Jun 2013.
Volk Susan W, Bohling Mark W: Comparative wound healing--are the small animal veterinarian's clinical patients an improved translational model for human wound healing research? Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 21(3): 372-81, May-Jun 2013.
Gordillo Gayle M, Bernatchez Stephanie F, Diegelmann Robert, Di Pietro Luisa A, Eriksson Elof, Hinz Boris, Hopf Harriet W, Kirsner Robert, Liu Paul, Parnell Laura K S, Sandusky George E, Sen Chandan K, Tomic-Canic Marjana, Volk Susan W, Baird Andrew: Preclinical Models of Wound Healing: Is Man the Model? Proceedings of the Wound Healing Society Symposium. Advances in wound care 2(1): 1-4, Feb 2013.
Adams Sherrill L, Margulies Susan, Volk Susan W: Phoebe S. Leboy, groundbreaking activist for women in STEM. DNA and cell biology 31(8): 1439, Aug 2012.
Volk Susan W, Wang Yanjian, Hankenson Kurt D: Effects of donor characteristics and ex vivo expansion on canine mesenchymal stem cell properties: implications for MSC-based therapies. Cell transplantation 21(10): 2189-200, 2012.
Volk SW*, Y Wang, EA Mauldin, KW Liechty and SL Adams: Diminished type III collagen promotes myofibroblast differentiation and increases scar deposition in cutaneous wound healing. Cells, Tissues, Organs 194(1): 25-37, 2011.
Anwer Cona, Schwarz Tobias, Volk Susan W, Vite Charles: BAER testing in a dog with bilateral external ear canal atresia. Journal of the American Animal Hospital Association 47(5): 370-4, Sep-Oct 2011.