Abraham Shaked

faculty photo
Eldridge L. Eliason Professor of Surgery
University Associate Level 1, The Children's Hospital of Philadelphia
Director, PENN Transplant Institute, University of Pennsylvania School of Medicine
Department: Surgery

Contact information
Hospital of the Univ. of Pennsylvania
Department of Surgery
2 Dulles
3400 Spruce Street
Philadelphia, PA 19104
Office: (215) 662-6723
Fax: (215) 662-2244
Education:
M.D.
Hebrew University, Israel, 1982.
Ph.D.
City University of New York, 1989.
Post-Graduate Training
Resident in Surgery PGY1, Hadassah University Hospital, Jerusalem, Israel, 1981-1982.
Resident in Surgery PGY III, Mount Sinai Medical Center, New York, NY, 1982-1983.
Resident in Surgery PGY II, Hadassah University Hospital, Jerusalem, Israel, 1983-1984.
PhD candidate, Biomedical Sciences Doctoral Program, Mount Sinai School of Medicine, New York, NY, 1984-1987.
Resident in Surgery PGY IV & V, Mount Sinai Medical Center, New York, NY, 1986-1988.
Chief Resident of Surgery PGY VI, Mount Sinai Medical Center, New York, NY, 1988-1989.
Fellow, Liver Transplantation Program, UCLA, Los Angeles, CA, 1989-1990.
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Description of Research Expertise

Research Interests

Dr. Shaked is a nationally recognized leader in the field of transplantation. For many years, Dr. Shaked's practice has focused on the surgical treatment of liver and hepatobiliary diseases. He is one of the most experienced surgeons in the country in adult and pediatric liver transplantation, and has a special interest in hepatobiliary malignancy, as well as biliary reconstruction.

Dr. Shaked's academic record is reflected by his achievements in basic laboratory research and support for clinical science investigation. His laboratory efforts focus on the application of gene transfer technology in the transplant setting.

Description of Itmat Expertise

The Shaked laboratory studies examine pathways of alloimmune, antigen-specific, and inflammatory response in the setting of human solid organ transplantation. Genomics, proteomics, and cell based assays are being correlated with clinical outcomes. These include: 1) The interrelation between inflammatory pathways and activation of alloimmune response in the immediate post-transplant setting; 2) Pattern of anti-HCV response and recurrent hepatitis C under immunosuppression; and 3) Markers of rejection and tolerance in urine and peripheral blood in recipients undergoing kidney and liver transplantation.

Selected Publications

Sulewski Michael E, Wolf Joshua H, Hasz Richard, West Sharon, Goldberg David, Krok Karen L, Olthoff Kim M, Shaked Abraham, Levine Matthew H, Abt Peter L: Combined heart-liver transplantation; implications for liver-alone wait list mortality. Transplantation 98(5): e45-7, Sep 2014.

Clayton Erica F, Malik Saloni, Bonnel Alexander, Mu Yifei, Olthoff Kim, Shaked Abraham, Abt Peter L, Peterman Heather, Rajender Reddy K, Ottmann Shane, Furth Emma E, Levine Matthew H: Liver transplantation and cirrhotomimetic hepatocellular carcinoma: classification and outcomes. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20(7): 765-74, Jul 2014.

Almoguera B, Shaked A, Keating B J: Transplantation genetics: current status and prospects. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 14(4): 764-78, Apr 2014.

O'Leary J G, Demetris A J, Friedman L S, Gebel H M, Halloran P F, Kirk A D, Knechtle S J, McDiarmid S V, Shaked A, Terasaki P I, Tinckam K J, Tomlanovich S J, Wood K J, Woodle E S, Zachary A A, Klintmalm G B: The role of donor-specific HLA alloantibodies in liver transplantation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 14(4): 779-87, Apr 2014.

Shaked O, Gonzalez A, Bahirwani R, Furth E, Siegelman E, Shaked A, Olthoff K, Reddy K R: Donor hemosiderosis does not affect liver function and regeneration in the setting of living donor liver transplantation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 14(1): 216-20, Jan 2014.

Enestvedt C Kristian, Malik Saloni, Reese Peter P, Maskin Alexander, Yoo Peter S, Fayek Sameh A, Abt Peter, Olthoff Kim M, Shaked Abraham: Biliary complications adversely affect patient and graft survival after liver retransplantation. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 19(9): 965-72, Sep 2013.

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Last updated: 10/19/2023
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