David M. Eckmann

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Horatio C. Wood Professor of Anesthesiology and Critical Care
Attending Physician, Department of Anesthesiology & Critical Care, Hospital of the University of Pennsylvania
Member, Institute for Medicine and Engineering, University of Pennsylvania Institute for Medicine and Engineering
Founding Member, Institute for Translational Medicine and Therapeutics, University of Pennsylvania Institute for Translational Medicine and Therapeutics
Member, Cardiovascular Institute, University of Pennsylvania Cardiovascular Institute
Professor of Bioengineering, University of Pennsylvania (Secondary Appointment)
Adjunct Investigator, University of Pennsylvania Institute for Environmental Medicine
Member, University of Pennsylvania Nano/Bio Interface Center
Department: Anesthesiology and Critical Care

Contact information
331 John Morgan Building/6112
3620 Hamilton Walk
Philadelphia, PA 19104-6802
Office: 215-349-5348
Fax: 215-349-5078
B.S. (Bioengineering)
University of California, San Diego, 1983.
Ph.D. (Biomedical Engineering)
Northwestern University, 1989.

Medical Scientist Training Program, Northwestern University, 1990.
M.D. (Medicine)
Northwestern University, 1990.
M.A. (Education (Honorary))
University of Pennsylvania, 2003.
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Description of Research Expertise

Interfacial fluid mechanics, bioenergetics, biofluid mechanics, biological fluid dynamics, vascular biology, cardiovascular physiology, surfactant, gas embolism, air embolism, cellular mechanics, computational fluid dynamics, surface tension, bubbles, biomaterials, biomimetic materials, surface adsorption, surface grafting, bioengineering, biomedical engineering, targeted drug delivery, nanocarriers, ICAM-1

Description of Itmat Expertise

1. Biomimetic macromolecular surface grafting for biocompatibility of vascular biomaterials. We are making biomimetic surface molecular constructs to improve biocompatibility and reduce bioresponses to blood contact to coated biomaterials.

2. Molecular basis for neuroprotection in cerebrovascular gas embolism. We are investigating the role of exogenous surfactants in altering mechanotransduction and cell signaling events to attenuate endothelial cell injury/death and mitigate CNS injury in cerebrovascular gas embolism.

3. Optimization of nanocarrier design for targeted vascular drug delivery. We combine experimental and computational techniques to assess design parameters (carrier size, shape, surface density of targeting binding molecules) to optimize carrier binding to vascular endothelium.

Selected Publications

Coll Ferrer, M.C., Zern, B., Composto, R.J., Muzykantov, V.R., Eckmann, D.M.: ICAM-1 targeted nanogels loaded with dexamethasone alleviate pulmonary inflammation. PLoS ONE 9(7): e102329, July 2014.

Kandel, J., Lee, H.S., Sobolewski, P., Tomczyk, N., Composto, R.J., Eckmann, D.M.: Chemically grafted fibronectin for use in QCM-D cell studies. Biosensors and Bioelectronics 58: 249-257, February 2014.

Lee, H.S., Stachelek, S.J., Tomczyk, N., Composto, R.J., Eckmann, D.M.: Correlating macrophage morphology and cytokine production resulting from biomaterial contact. Journal of Biomedical Materials Research Part A 101(1): 203-212, January 2013.

Sobolewski, P., Kandel, J., Eckmann, D.M.: Air bubble contact with endothelial cells causes a calcium-independent loss in mitochondrial membrane potential. PLoS ONE 7(10): e47254, October 2012.

Lee, H.S., Yee, M.Q., Eckmann, Y.Y., Hickok, N.J., Eckmann, D.M., Composto, R.J.: Tuning the swelling of chitosan brushes by varying quaternary ammonium salt content and counterion type. Journal of Materials Chemistry 22: 19605-19616, September 2012.

Coll Ferrer, M.C., Hickok, N.J., Eckmann, D.M., Composto, R.J.: Antibacterial biomimetic hybrid films. Soft Matter 8: 2423-2431, February 2012.

Calderon, A.J., Bhowmick, T., Leferovich, J., Burman, B., Pichette, B., Muzykantov, V.N., Eckmann, D.M.*, Muro, S.*: Optimizing endothelial targeting by modulating the antibody density and particle concentration of anti-ICAM coated carriers. Journal of Controlled Release 150: 37-44, February 2011 Notes: *equal contributions as corresponding authors.

Sobolewski, P., Kandel, J., Klinger, A.L., Eckmann, D.M.: Air bubble contact with endothelial cells in vitro induces calcium influx and IP3-dependent release of calcium stores. American Journal of Physiology - Cell Physiology 301(3): C679-C686, August 2011.

Stachelek, S.J., Finley, M.J., Alferiev, I., Wang, F., Tsai, R., Eckells, E.C., Tomczyk, N., Connolly, J.M., Discher, D.E., Eckmann, D.M., Levy, R.J.: The effect of CD 47 modified polymer surfaces on inflammatory cell attachment and activation. Biomaterials 32: 4317-4326, July 2011.

Liu, J., Weller, G.E.R., Zern, B., Ayyaswamy, P.S., Eckmann, D.M., Muzykantov, V., Radhakrishnan, R.: A computational model for nanocarrier binding to endothelium validated using in vivo, in vitro, and Atomic Force Microscopy experiments. Proceedings of the National Academy of Sciences 107(38): 16530-16535, September 2010.

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Last updated: 01/28/2015
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