David E Holt

faculty photo
Professor of Surgery, University of Pennsylvania School of Veterinary Medicine

Contact information
Department of Clinical Studies
Veterinary Hospital
University of Pennsylvania
3900 Delancey Street
Philadelphia, PA 19104
Office: 215-898-4680
Fax: 215-573-9457
Education:
BVSc (Veterinary Science)
University of Sydney, Sydney, Australia, 1983.
Post-Graduate Training
Intern, University of Pennsylvania School of Veterinary Medicine Philadelphia, PA 19104, 1985-1986.
Resident in Small Animal Surgery, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, 1987-1990.
Permanent link
 
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Description of Research Expertise

Imaging cancer during surgery,
Portosystemic shunts,
Brachycephalic airway disease,
Laryngeal paralysis,

Description of Other Expertise

Open water swimming,
Surfing,
Kitesurfing

Description of Itmat Expertise

Near infra-red imaging of cancer in spontaneous large animal models

Selected Publications

Phillips H, Corrie J, Engel DM, Duffy DJ, Holt DE, Kendall AR, Schmiedt CW, Vetter A, Meren IL, Follette C, Schaeffer DJ, Mayhew PD, Marks SL: Clinical findings, diagnostic test results, and treatment outcome in cats with hiatal hernia: 31 cases (1995-2018). Journal of Veterinary Internal Medicine Aug 2019.

Pierce John T, Cho Steve S, Nag Shayoni, Zeh Ryan, Jeon Jun, Holt David, Durham Amy, Nasrallah MacLean P, Singhal Sunil, Lee John Y K: Folate Receptor Overexpression in Human and Canine Meningiomas-Immunohistochemistry and Case Report of Intraoperative Molecular Imaging. Neurosurgery 85(3): 359-368, Sep 2019.

Predina JD, Runge J, Newton A, Mison M, Xia L, Corbett C, Shin M, Sulyok Lydia F, Durham A, Nie S, Singhal S, Holt D: Evaluation of Aminolevulinic Acid-Derived Tumor Fluorescence Yields Disparate Results in Murine and Spontaneous Large Animal Models of Lung Cancer. Scientific Reports 9(1): 7629, May 2019.

Morris Katherine P, Singh Ameet, Holt DE, Stefanovski D, Singhal S, Bosco J, Capps M, McCallum M, Runge JJ: Hybrid single-port laparoscopic cisterna chyli ablation for the adjunct treatment of chylothorax disease in dogs. Veterinary Surgery : VS 48(S1): O121-O129, Jun 2019.

Mayhew PD, Boston SE, Zwingenberger AL, Giuffrida MA, Runge JJ, Holt DE, Raleigh JS, Singh A, Culp WTN, Case JB, Steffey MA, Balsa IM: Perioperative morbidity and mortality in dogs with invasive adrenal neoplasms treated by adrenalectomy and cavotomy. Veterinary Surgery : VS 48(5): 742-750, Jul 2019.

Tarrant JC, Holt DE, Durham AC: Co-occurrence of Nasal Polyps and Neoplasms of the Canine Nasal Cavity. Veterinary Pathology Page: 300985819854438, Jun 2019.

Hsueh C, Giuffrida M, Mayhew PD, Case JB, Singh A, Monnet E, Holt DE, Cray M, Curcillo C, Runge JJ: Evaluation of pet owner preferences for operative sterilization techniques in female dogs within the veterinary community. Veterinary Surgery : VS 47(S1): O15-O25, Jun 2018.

Armstrong AJ, Hauptman JG, Stanley BJ, Klocke E, Burneko M, Holt DE, Runge JJ, Rubin JA: Effect of Prophylactic Calcitriol Administration on Serum Ionized Calcium Concentrations after Parathyroidectomy: 78 Cases (2005-2015). Journal of Veterinary Internal Medicine 32(1): 99-106, Jan 2018.

Baron J, Giuffrida M, Mayhew PD, Singh A, Case JB, Culp WTN, Holt DE, Mayhew KN, Runge JJ: Minimally invasive small intestinal exploration and targeted abdominal organ biopsy with a wound retraction device in 42 cats (2005-2015). Veterinary Surgery : VS 46(7): 925-932, Oct 2017.

Keating JJ, Runge JJ, Singhal S, Nims S, Venegas O, Durham AC, Swan G, NS, Low PS, Holt DE: Intraoperative near-infrared fluorescence imaging targeting folate receptors identifies lung cancer in a large-animal model. Cancer 123(6): 1051-1060, 05 2017.

Majeski SA, Steffey MA, Mayhew PD, Hunt GB, Holt DE, Runge JJ, Kass PH, Mellema M: Postoperative Respiratory Function and Survival After Pneumonectomy in Dogs and Cats. Veterinary Surgery : VS 45(6): 775-81, Aug 2016.

Keating JJ, Nims S, Venegas O, Jiang J, Holt DE, Kucharczuk JC, Deshpande C, Singhal S: Intraoperative imaging identifies thymoma margins following neoadjuvant chemotherapy. Oncotarget 7(3): 3059-67, Jan 2016.

Judy RP, Keating JJ, DeJesus EM, Jiang JX, Okusanya OT, Nie S, Holt DE, Arlauckas SP, Low PS, Delikatny EJ, Singhal S: Quantification of tumor fluorescence during intraoperative optical cancer imaging. Scientific Reports 5: 16208, Nov 2015.

Holt D, Parthasarathy AB, Okusanya O, Keating J, Venegas O, Deshpande C, Karakousis G, Madajewski B, Durham A, Nie S, Yodh AG, Singhal S: Intraoperative near-infrared fluorescence imaging and spectroscopy identifies residual tumor cells in wounds. Journal of Biomedical Optics 20(7): 76002, Jul 2015.

Guevara JL, Holmes ES, Reetz J, Holt DE: Porcupine quill migration in the thoracic cavity of a German shorthaired pointer. Journal of the American Animal Hospital Association 51(2): 101-6, Mar-Apr 2015.

Rubin JA, Holt DE, Reetz JA, Clarke DL: Signalment, clinical presentation, concurrent diseases, and diagnostic findings in 28 dogs with dynamic pharyngeal collapse (2008-2013). Journal of Veterinary Internal Medicine 29(3): 815-21, May-Jun 2015.

Wormser C, Singhal S, Holt DE, Runge JJ: Thoracoscopic-assisted pulmonary surgery for partial and complete lung lobectomy in dogs and cats: 11 cases (2008-2013). Journal of the American Veterinary Medical Association 245(9): 1036-41, Nov 2014.

Holt D, Okusanya O, Judy R, Venegas O, Jiang J, DeJesus E, Eruslanov E, Quatromoni J, Bhojnagarwala P, Deshpande C, Albelda S, Nie S, Singhal S: Intraoperative near-infrared fluorescence imaging and spectroscopy identifies residual tumor cells in wounds. PloS One 9(7): e103342, 2014.

Okusanya OT, Holt D, Heitjan D, Deshpande C, Venegas O, Jiang J, Judy R, DeJesus E, Madajewski B, Oh K, Wang M, Albelda SM, Nie S, Singhal S: Intraoperative near-infrared imaging can identify pulmonary nodules. The Annals of Thoracic Surgery 98(4): 1223-30, Oct 2014.

Lo AJ, Holt DE, Brown DC, Schlicksup MD, Orsher RJ, Agnello KA: Treatment of aldosterone-secreting adrenocortical tumors in cats by unilateral adrenalectomy: 10 cases (2002-2012). Journal of Veterinary Internal Medicine 28(1): 137-43, Jan-Feb 2014.

Holt DE, Henthorn P, Howell VM, Robinson BG, Benn DE: Succinate dehydrogenase subunit D and succinate dehydrogenase subunit B mutation analysis in canine phaeochromocytoma and paraganglioma. Journal of Comparative Pathology 151(1): 25-34, Jul 2014.

Schlicksup MD, Holt DE, Mai W, Holmes ES, Agnello KA: The effect of abaxial retraction on pelvic geometry after pelvic symphysiotomy. Veterinary Surgery : VS 42(8): 958-62, Nov 2013.

Runge JJ, Curcillo PG, King SA, Podolsky ER, Holt DE, Davidson J, Agnello KA: Initial application of reduced port surgery using the single port access technique for laparoscopic canine ovariectomy. Veterinary Surgery : VS 41(7): 803-6, Oct 2012.

Shanaman M, Seiler G, Holt DE: Prevalence of clinical and subclinical middle ear disease in cats undergoing computed tomographic scans of the head. Veterinary Radiology & Ultrasound : The Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association 53(1): 76-9, Jan-Feb 2012.

Holt DE, Goldschmidt MH: Nasal polyps in dogs: five cases (2005 to 2011). The Journal of Small Animal Practice 52(12): 660-3, Dec 2011.

Holt DE, Runge J: Use of skin stretchers to elongate a peninsular thoracodorsal axial pattern flap for antebrachial wound closure in a dog. Veterinary Surgery : VS 40(3): 352-6, Apr 2011.

Clarke DL, Holt DE, King LG: Partial resolution of hypoplastic trachea in six english bulldog puppies with bronchopneumonia. Journal of the American Animal Hospital Association 47(5): 329-35, Sep-Oct 2011.

Madjewski, B, Judy BF, Mouchli A, Kapoor V, Wang MD, Nie S, Holt DE, Singhal S. Intraoperative Near-Infrared Imaging of Surgical Wounds after Tumor Resections Can Detect Residual Disease. Clinical Cancer Research, 18:1-11, 2012.

Busschers E, Epstein KL, Holt DE, Parente EJ: Extraluminal, C shaped polyethylene prostheses in two ponies with tracheal collapse. Veterinary Surgery : VS 39(6): 776-83, Aug 2010.

Holt DE, Mover MR, Brown DC: Serologic prevalence of antibodies against canine influenza virus (H3N8) in dogs in a metropolitan animal shelter. Journal of the American Veterinary Medical Association 237(1): 71-3, Jul 2010.

Eisele J, McClaran JK, Runge JJ, Holt DE, Culp WT, Liu S, Long F, Bergman PJ: Evaluation of risk factors for morbidity and mortality after pylorectomy and gastroduodenostomy in dogs. Veterinary Surgery : VS 39(2): 261-7, Feb 2010.

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Last updated: 08/27/2019
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