Janet L Kwiatkowski

faculty photo
Professor of Pediatrics at the Children's Hospital of Philadelphia
Consulting Hematologist, Hospital of the University of Pennsylvania
Consulting Hematologist, Pennsylvania Hospital
Director, Thalassemia Program, Children's Hospital of Philadelphia
Department: Pediatrics

Contact information
The Children's Hospital of Philadelphia
Division of Hematology
3401 Civic Center Blvd
Colket Translational Research Building, Room 11024
Philadelphia, PA 19104
Office: 215-590-5286
Education:
B.S. (Zoology)
Duke University, summa cum laude, 1988.
M.D.
Columbia University, College of Physicians & Surgeons, 1992.
MSCE (Clinical Epidemiology and Biostatistics)
University of Pennsylvania, 2003.
Permanent link
 

Description of Research Expertise

Optimization of iron chelation, monitoring transfusional iron overload, stroke prevention in sickle cell disease, headaches in sickle cell disease, complications of thalassemia, transfusion therapy

Description of Itmat Expertise

The research interests of Dr. Kwiatkowski include stroke and stroke prevention in sickle cell disease, transfusional iron overload and chelation therapy, and diagnosis and treatment of clinical complications of thalassemia.

Selected Publications

Riley LG, Heeney MM, Rudinger-Thirion J, Frugier M, Campagna DR, Zhou R, Hale GA, Hilliard LM, Kaplan JA, Kwiatkowski JL, Sieff CA, Steensma DP, Rennings AJ, Simons A, Schaap N, Roodenburg RJ, Kleefstra T, Arenillas L, Fita-Torró J, Ahmed R, Abboud M, Bechara E, Farah R, Tamminga RY, Bottomley SS, Sanchez M, Swinkels DW, Christodoulou J, Fleming MD.: The phenotypic spectrum of germline YRS2 variants: from isolated sideroblastic anemia to mitochondrial myopathy, lactic acidosis and sideroblastic anemia 2. Haematologica Page: in press, July 2018.

Thompson A, Walters M, Kwiatkowski J, Ribeil J-A, Rasko J, Hongeng S, Magrin E, Schiller G, Payen E, Semeraro M, Moshous D, Lefrere F, Puy H, Magnani A, Caccavelli L, Diana J-S, Suarez F, Monpoux F, Brouse V, Poirot C, Brouzes C, Meritet, J-F, Pondarre C, Buezard Y, Chretien S, Lefebvre T, Teachey D, Anurathapan U, Ho P, von Kalle C, Kletzel M, Vichinsky E, Soni S, Veres G, Negre O, Ross R, Davidson D, Petrusich A, Sandler L, Asmal M, Hermine O, de Montalembert M, Blanche S, Leboulch P, Cavazzano-Calvo M: Gene Therapy for Transfusion-Dependent Beta-thalassemia. New England Journal of Medicine 378(16): 1479-1493, April 2018.

Hammond J, Thompson AA, Fogel MA, Hammond K, Kokroko J, Kwiatkowski JL: Combination oral chelation in adult patients with transfusion-dependent thalassemia and high iron burden. Journal of Pediatric Hematology/Oncology 2018 Notes: in press.

van Beers EJ, van Straaten S, Morton DH, Barcellini W, Eber SW, Glader B, Yaish HM, Chonat S, Kwiatkowski JL, Rothman JA, Sharma M, Neufeld EJ, Sheth S, Despotovic JM, Kollmar N, Pospisilova D, Knoll CM, Kuo K, Pastore YD, Thompson AA, Newburger PE, Ravindranath Y, Wang WC, Wlodarski MW, Wang H, Holzhauer S, Breakey VR, Verhovsek M, Kunz J, McNaull MA, Rose MJ, Bradeen HA, Addonizio K, Li A, Al-Sayegh H, London WB, Grace RF: Prevalence and management of iron overload in pyruvate kinase deficiency; report from the Pyruvate Kinase Deficiency Natural History Study. Haematologica Page: in press, 2018.

Shenoy S, Walters MC, Ngwube A, Soni S, Jacobsohn D, Chaudhury S, Grimley M, Chan K, Haight A, Kasow KA, Parikh S, Andreansky M, Connelly J, Delgado D, Godder K, Hale G, Nieder M, Pulsipher MA, Trachtenberg F, Neufeld E, Kwiatkowski JL, Thompson AA.: Unrelated donor transplantation in children with thalassemia using reduced-intensity conditioning: the URTH Trial. Biol Blood Marrow Transplant 2018 Notes: in press.

Grace RF, Bianchi P, van Beers EJ, Eber SW, Glader B, Yaish HM, Despotovic JM, Rothman JA, Sharma M, McNaull MM, Fermo E, Lezon-Geyda K, Morton DH, Neufeld EJ, Chonat S, Kollmar N, Knoll CM, Kuo K, Kwiatkowski JL, Pospíŝilová D, Pastore YD, Thompson AA, Newburger PE, Ravindranath Y, Wang WC, Wlodarski MW, Wang H, Holzhauer S, Breakey VR, Kunz J, Sheth S, Rose MJ, Bradeen HA, Neu N, Guo D, Al-Sayegh H, London WB, Gallagher PG, Zanella A, Barcellini W.: Clinical spectrum of pyruvate kinase deficiency: data from the Pyruvate Kinase Deficiency Natural History Study. Blood 131(20): 2183-2192, 2018.

Vichinsky E, Cohen A, Thompson AA, Giardina PJ, Lal A, Paley C, Cheng WY, McCormick N, Sasane M, Qiu Y, Kwiatkowski JL: Epidemiologic and clinical characteristics of nontransfusion-dependent thalassemia in the United States. Pediatric Blood & Cancer 65(7): e27067, 2018.

Kwiatkowski JL: Thalassemia minor. Case Studies in Hematology & Coagulation. Gulati G, Filicko-O'Hara J, Krause JJ (eds.). American Society for Clinical Pathology Press, 2nd edition, 2017 (in press).

Kwiatkowski JL: Beta Thalassemia Major. Case Studies in Hematology & Coagulation. Gulati G, Filicko-O'Hara J, Krause JR (eds.). American Society for Clinical Pathology Press, 2nd edition, 2017 (in press).

Belmont Ami, Kwiatkowski Janet L: Deferiprone for the treatment of transfusional iron overload in thalassemia. Expert Review of Hematology 10(6): 493-503, Jun 2017.

back to top
Last updated: 09/18/2018
The Trustees of the University of Pennsylvania