Vera P. Krymskaya

faculty photo
Professor of Medicine
Member, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
Member, Center for Excellence in Environmental Toxicology, University of Pennsylvania, Philadelphia, PA
Member, Pulmonary Vascular Disease Program, Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA
Member, LAM Clinic, University of Pennsylvania
Member, CVI Pulmonary Vascular Disease Program
Director of Education, Airways Biology Initiative, University of Pennsylvania
Member, Institute for Translational Medicine and Therapeutics
Member, Penn Center for Orphan Disease Research and Therapy
Member, The University Council Committee on Academic and Related Affairs
Department: Medicine

Contact information
Translational Research Laboratories
Suite 1200, Room 1213
125 South 31st Street
Philadelphia, PA 19104-3403
Office: (215) 573-9861
Fax: (215) 746-1224
Lab: (215) 746-3599
Graduate Group Affiliations
BA (Piano)
Ternopol College of Music, Ukraine, 1980.
MBA (Marketing Management)
Plekhanov Institute of Economics, Moscow, USSR, 1986.
PhD (Biology/Radiation Biology)
Department of Biophysics, Moscow State University, Moscow, USSR, 1991.
Permanent link

Description of Research Expertise

Basic and translational research in rare and common lung diseases: pulmonary lymphangioleiomyomatosis (LAM), tuberous sclerosis (TS), Birt-Hogg-Dube (BHD); Multicentric Castleman Disease (MCD), pulmonary arterial hypertension (PAH), asthma; Cellular signaling networks: phosphatidylinositol 3-kinase (PI3K), Akt, tumor suppressor complex TSC1/TSC2, protein translational regulation, mTOR,LKB1, AMPK, FLCN, RhoA GTPase, Rac1 GTPase, STAT3; Airway smooth muscle cell biology and remodeling,vascular smooth muscle cell biology and remodeling, cell growth, cell proliferation, cell migration, invasiveness; animal models of lung diseases.

Description of Other Expertise

Marketing management, concert piano

Description of Itmat Expertise

Molecular and cellular biology of pulmonary diseases; signal transduction mechanisms; rare lung diseases; chronic obstractive pulmonary disease; animal models of lung diseases, cancer; pulmonary arterial hypertention, asthma

Selected Publications

Elena A. Goncharova, Dmitry A. Goncharov, Melane L. James, Elena N. Atochina-Vasserman, Seung-Beom Hong, Hua Li, Linda Gonzales, Masaya Baba, W. Marston Linehan, Susan Margulies, Susan Guttentag, Laura S. Schmidt, and Vera P. Krymskaya : Folliculin Controls Lung Alveolar Enlargement and Epithelial Cell Survival through E-Cadherin, LKB1 and AMPK Cell Reports 7: 412-423, April 2014 Notes: Highlighted in Cell Reports.

Elena A. Goncharova, Dmitry A. Goncharov, Melane Fehrenbach, Irene Khavin, Blerina Ducka, Okio Hino, Thomas V. Colby, Mervyn J. Merrilees, Angela Haczku, Steven M. Albelda, and Vera P. Krymskaya: Prevention of Alveolar Destruction and Airspace Enlargement in a Mouse Model of Pulmonary Lymphangioleiomyomatosis (LAM). Science Translational Medicine 4(154): 154ra134, October 2012 Notes: cited by F1000Prime.

Goncharova EA, Goncharov DA, Li H, Pimtong W, Lu S, Khavin I, Krymskaya VP: mTORC2 is required for proliferation and survival of TSC2-null cells Molecular and Cellular Biology 31: 2484-2498, March 2011.

Dmitry A. Goncharov, Tatiana Kudryashova, Houman Ziai, Kaori Ihida-Stansbury, Horace DeLisser1,3, Vera P. Krymskaya, Rubin M. Tuder, Steven M. Kawut, Elena A. Goncharova: mTORC2 coordinates pulmonary artery smooth muscle cell metabolism, proliferation and survival in pulmonary arterial hypertension. Circulation 129: 864-874, February 2014.

Elena A. Goncharova, Dmitry A. Goncharov, and Vera P. Krymskaya: Tumor suppressors TSC1 and TSC2 differentially modulate actin cytoskeleton and motility of mouse embryonic fibroblasts. The LAM Foundation 17th Annual International Conference Page: 48, April 2014 Notes: Poster Presentation.

Atochina-Vasserman EN, Guo CJ, Abramova E, Golden TN, Sims M, James ML, Beers MF, Gow AJ, Krymskaya VP: Surfactant Dysfunction and Lung Inflammation in the Female Mouse Model of Lymphangioleiomyomatosis. American Journal of Respiratory Cell and Molecular Biology 53(1): 96-104, July 2015 Notes: Higlighted paper in the Red Alert.

Goncharova EA, Goncharov DA, Noonan D, Krymskaya VP: TSC2 modulates actin cytoskeleton and cell adhesion through TSC1-binding domain and Rac1 GTPase. Journal of Cell Biology 167: 1171-1182, 2004 Notes: Highlighted in Nat. Cell Biol.

Goncharova EA, Goncharov DA, Eszterhas A, Hunter DS, Glassberg MK, Yeung RS, Walker CL, Noonan D, Kwiatkowski DJ, Chou MM, Panettieri Jr RA, Krymskaya VP: Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM). Journal of Biological Chemistry 277(34): 30958-67, Aug 23 2002 Notes: Cited in Nat. Cell Biol.

Stephen R. Hammes and Vera P. Krymskaya : Targeted Approaches Toward Understanding and Treating Pulmonary Lymphangioleiomyomatosis (LAM). Hormones and Cancer 4(2), April 2013.

Vera P. Krymskaya: Therapeutic Strategies for Treatment of Pulmonary Lymphangioleiomyomatosis (LAM). Expert Opinion on Orphan Drugs 2(10): 1063-1074, August 2014.

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Last updated: 11/16/2015
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