Lance B. Becker

faculty photo
Professor of Emergency Medicine
Director, Center for Resuscitation Science, Hospital of the University of Pennsylvania, Philadelphia, PA
Chair, Critical Care Planning Committee, Perelman School of Medicine, University of Pennsylvania Health System
Professor, Center for Mitochondrial and Epigenomic Medicine (CMEM) at The Children's Hospital of Philadelphia, University of Pennsylvania
Division Chief, Perelman School of Medicine, University of Pennsylvania Health System, Department of Emergency Medicine
Department: Emergency Medicine

Contact information
Center for Resuscitation Science
Department of Emergency Medicine
Colket Translational Research Building
3501 Civic Center Boulevard
Suite 6024
Philadelphia, PA 19104-4399
Office: 267-425-0050
Fax: 267-426-0978
Lab: 267-425-0051
BGS (General Studies)
University of Michigan, 1975.
MA (Biochemistry)
University of Illinois, 1977.
MD (Medicine)
University of Illinois School of Medicine, 1981.
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Description of Research Expertise

Lance B. Becker, MD, is a newly recruited Professor of Emergency Medicine at the University of Pennsylvania. Previously Dr. Becker was a Professor at the University of Chicago's Department of Medicine, Section of Emergency Medicine. He was the founder and Director of the Emergency Resuscitation Center at the University of Chicago in Chicago and Argonne National Laboratory, an interdisciplinary team of investigators focused on understanding and treating sudden death from cardiac arrest and from traumatic injuries. He is board certified in internal medicine, emergency medicine and critical care medicine.

Dr. Becker has received numerous national awards and recognition for his work and leadership. He was selected by Emergency Medicine residents as the "Attending Physician of the Year" in 1997, has been awarded the "Time, Feeling, and Focus" award from the American Heart Association, as well as other leadership awards from the National Emergency Cardiac Care Committee of the American Heart Association. Dr. Becker was the National Conference Director for the American Heart Association's Emergency Cardiac Care Evidence Evaluation Conference in September 1999 to create new national CPR recommendations, has served on the National American Heart Association's Basic Life Support Committee and Advanced Life Support subcommittees. He has been a past Chair of the Cardiopulmonary, Perioperative, and Critical Care Council of the American Heart Association and is a past Chairman of the Basic Life Support Committee. He has served as representative to the International Liaison Committee on Resuscitation and helped create and continues to Co-Direct the Resuscitation Science Symposium of the American Heart Association, the leading international venue for the presentation of cutting edge science in resuscitation. At the most recent 2005 International AHA Guidelines Conference for consensus on international resuscitation science and new CPR recommendations, he acted as the Chair for the daily "Controversial Topics" sessions that revisited the most challenging resuscitation topics each day. Dr. Becker has worked closely with the NIH as a reviewer, grantee, and in a leadership role as a the Chair of the Myocardial Protection Working group for the NIH NHLBI's sponsored PULSE Conference and PULSE Leadership Group, which is dedicated to support of research funding in resuscitation research. He also served as a member of the Food and Drug Administration Device Evaluation panels and has appeared before the FDA panels as an expert presenter.

Dr. Becker' research interests are very translational and extend across the basic science laboratory into animal models of resuscitation, and to human therapies. He developed the Emergency Resuscitation Center at the University of Chicago to bring investigators from diverse fields together for multidisciplinary resuscitation research and for improved training of young resuscitation scientists. His cellular studies have helped define cellular reperfusion injury mechanisms, mitochondrial oxidant generation, reactive oxygen and nitrogen species responses to ischemia, apoptotic activation following ischemia, signaling pathways, new cellular cytoprotective strategies, and hypothermia protection. Additional studies are ongoing on development of novel human coolants for rapid induction of hypothermia, inflammatory pathways activated following shock and cardiac arrest, improving the quality of CPR, new defibrillator and cardiopulmonary bypass technologies, epidemiology of sudden death, and novel treatments for cardiac arrest.

Description of Itmat Expertise

Dr. Becker's studies in resuscitation science are leading to new therapeutics for saving lives of patients who are critically injured, hypotensive in shock and suffering from cardiac arrest.

Selected Publications

Weiss SL, Selak MA, Tuluc F. Perales Villarroel J, Nadkarni VM, Deutschman CS, Becker LB. : “Mitochondrial dysfunction in peripheral blood mononuclear cells in pediatric septic shock”. Pediatr Crit Care Med. 16(1), January 2015.

Sutton RM, Friess SH, Naim MY, Lampe JW, Bratinov G. Weiland TR 3rd, Garuccio M, Nadkarni VM, Becker LB, Berg RA. : “Patient-centric blood pressure-targeted cardiopulmonary resuscitation improves survival from cardiac arrest”. Am J Respir Crit Care Med. 190(11): 1255-62, December 2014.

Greenberg MR, Safdar B, Choo EK, McGregor AJ, Becker LB, Cone DC. : “Future directions in sex- and gender-specific Emergency Medicine” Acad Emerg Med. 21(12): 1339-42, December 2014.

Mgbako OU, Ha YP, Ranard BL, Hypolite KA, Sellers AM, Nadkarni LD, Becker LB, Asch DA, Merchant RM. : “Defibrillation in the movies: a missed opportunity for public health education” Resuscitation 85(12): 1795-8, December 2014.

Wang H. Guan Y, Widlund AL, Becker LB, Baur JA, Reilly PM, Sims CA.: “Resveratrol ameliorates mitochondrial dysfunction but increases the risk of hypoglycemia following hemorrhagic shock” J Trauma Acute Care Surg. 77(6): 926-33, December 2014.

Merchant RM, Griffis HM, Ha YP, Kilaru AS, Sellers AM, Hershey JC, Hill SS, Kramer-Golinkoff E, Nadkarni L, Debski MM, Padrez KA, Becker LB, Ash DA. : “Hidden in plain sight: a crowdsourced public art contest to make automatic external defibrillators more visible”. Am J Public Health 104(12): 2306-12, December 2014.

Shinozaki K, Lampe JW, Wang CH, Yin T, Kim J, Oda S, Hirasawa H, Becker LB. : “Developing duel hemofiltration plus cardiopulmonary bypass in rodents”. J Surg Res. December 2014.

Kim J, Yin T, Ming Y, Zhang W, Shinozaki K, Selak MA, Pappan KL, Lampe JW, Becker LB. : “Examination of Physiological Function and Biochemical Disorders in a Rat Model of Prolonged Asphyxia-Inducted Cardiac Arrest followed by Cardio Pulmonary Bypass Resuscitation” PLOS ONE November 2014.

Paulson S, Becker LB, Parnia S, Mayer SA: "Reversing death: the miracle of modern medicine" Ann NY Acad Sci. July 2014.

Wang CH, Chou NK, Becker LB, Lin JW, YU HY, Chi NH, Hunag SC, Ko WJ, Wang SS, Tseng LJ, Lin MH, Wu IH, MA MH, Chen YS: "Improved outcome of extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest – A comparison with that for extracorporeal rescue for in-hospital cardiac arrest" Resuscitation June 2014.

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Last updated: 04/20/2015
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