Alexander C. Wright

faculty photo
Adjunct Associate Professor of Radiology
Department: Radiology

Contact information
Radiology, 1 Silverstein
3400 Spruce Street
Philadelphia, PA 19104
Education:
B.S. (Physics)
Georgia Institute of Technology, 1986.
Ph.D. (Physics)
Georgia Institute of Technology, 1991.
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Description of Research Expertise

Dr. Wright’s research involves the development of micro-MRI and micro-CT hardware, acquisition strategies and quantitative methods for the purpose of imaging the microstructure of biological tissues at cellular resolution. This includes the design and construction of novel and optimized radio-frequency and gradient coils for micro-MRI, and the development of quantitative image acquisition and analysis techniques for the characterization of tissue micro-architecture using both micro-MRI and micro-CT. Current focus is on developing micro-MRI methods for imaging the intervertebral disc ex vivo in order to measure collagen fiber architecture in the annulus fibrosus of the disc. In addition, micro-CT techniques are being developed for imaging and characterizing structural phenotypes in both soft-tissue and calcified specimens at extremely high resolution (1-10 µm isotropic). Another research effort involves the design, construction and implementation of transmit-receive RF coils for in vivo MRI of bone in the human tibia, using a whole-body 7 Tesla MRI scanner.

Description of Itmat Expertise

Development of micro-MRI and micro-CT hardware, acquisition strategies and quantitative methods for imaging micro-structure of biological tissues at cellular resolution.

Selected Publications

Z. Zhou, A. T. Tang, W. Y. Wong, S. Bamezai, L. M. Goddard, R. Shenkar, S. Zhou, J. Yang, A. C. Wright, M. Foley, J. S. Arthur, K. J. Whitehead, I. A. Awad, D. Y. Li, X. Zheng, M. L. Kahn: Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling. Nature March 2016 Notes: Mar 30. doi: 10.1038/nature17178. [Epub ahead of print]

A. C. Wright, J. H. Yoder, E. J. Vresilovic, D. M. Elliott: Theory of MRI contrast in the annulus fibrosus of the intervertebral disc. Magnetic Resonance Materials in Physics, Biology, and Medicine January 2016 Notes: MAGMA. 2016 Jan 11. [Epub ahead of print]

B. L. Showalter, J. F. DeLucca, J. M. Peloquin, D. H. Cortes, J. H. Yoder, N. T. Jacobs, A. C. Wright, J. C. Gee, E. J. Vresilovic, D. M. Elliott: A novel human intervertebral disc strain template to quantify regional three-dimensional strains in a population and compare to internal strains predicted by a finite element model. Journal of Orthopaedic Research December 2015 Notes: doi: 10.1002/jor.23137. [Epub ahead of print]

C. S. Rajapakse, M. Bashoor-Zadeh, C. Li, W. Sun, A. C. Wright, F. W. Wehrli: Volumetric cortical bone porosity assessment with MR imaging: validation and clinical feasibility. Radiology 276(2): 526-535, August 2015.

J. E. McDonough, L. Knudsen, A. C. Wright, W. M. Elliott, M. Ochs, J. C. Hogg: MicroCT measurement of alveolar number shows alveolar density is related to lung height in human lungs. Journal of Applied Physiology (1985) 118(11): 1429-1434, June 2015.

J. Huang, T. Wang, A. C. Wright, J. Yang, S. Zhou, L. Li, J. Yang, A. Small, M. S. Parmacek: Myocardin is required for maintenance of vascular and visceral smooth muscle homeostasis during postnatal development. Proceedings of the National Academy of Sciences, USA 112(14): 4447-4452, April 2015.

J. H. Yoder, J. M. Peloquin, G. Song, N. J. Tustison, S. M. Moon, A. C. Wright, E. J. Vresilovic, J. C. Gee, D. M. Elliott: Internal three-dimensional strains in human intervertebral discs under axial compression quantified noninvasively by magnetic resonance imaging and image registration. Journal of Biomechanical Engineering 136(11): 111008 (9 pages), November 2014.

D. H. Cortes, J. F. Magland, A. C. Wright, D. M. Elliott: The shear modulus of the nucleus pulposus measured using magnetic resonance elastography: A potential biomarker for intervertebral disc degeneration. Magnetic Resonance in Medicine 72(1): 211-219, July 2014.

J. M. Peloquin, J. H. Yoder, N. T. Jacobs, S. M. Moon, A. C. Wright, E. J. Vresilovic, D. M. Elliott: Human L3L4 intervertebral disc mean 3D shape, modes of variation, and their relationship to degeneration. Journal of Biomechanics 47(10): 2452-2459, July 2014.

A. C. Seifert, C. Li, C. S. Rajapakse, M. Bashoor-Zadeh, Y. A. Bhagat, A. C. Wright, B. S. Zemel, A. Zavaliangos, F. W. Wehrli: Bone mineral (31)P and matrix-bound water densities measured by solid-state (31)P and (1)H MRI. NMR in Biomedicine 27(7): 739-748, July 2014.

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Last updated: 04/07/2016
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