Tilo Grosser

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Research Associate Professor of Pharmacology
Member, Institute for Translational Medicine and Therapeutics, University of Pennsylvania
Director of Scientific Operations, Institute for Translational Medicine and Therapeutics, University of Pennsylvania Perelman School of Medicine
Department: Pharmacology

Contact information
Department of Systems Pharmacology and Translational Therapeutics
University of Pennsylvania Perelman School of Medicine
Smilow Center for Translational Research
3400 Civic Center Boulevard, Building 421
10th Floor, Room 103
Philadelphia, PA 19104-5158
Office: (215) 573-7600
Graduate Group Affiliations
Education:
M.D. (Medicine)
Heinrich-Heine University, Düsseldorf, Germany, 1996.
Dr. med. (Medical research doctorate in Cardiovascular Pharmacology)
Heinrich-Heine University, Düsseldorf, Germany, 1998.
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Description of Research Expertise

Dr. Grosser's lab studies the human biology of inflammation and the translational therapeutics of lipid mediators. He is interested in understanding how the benefit of drugs targeting lipid mediators (e.g. NSAIDs) can be exploited while managing or avoiding their adverse effects. If this can be established for NSAIDs, where there is a subtle trade-off between benefit and risk at the population level (but less subtle at the individual level), it may serve as a general paradigm for the personalization of other commonly used classes of drugs. Dr. Grosser conducts human deep-phenotyping trials designed to elucidate genomic and non-genomic variability in the response to drugs. He studies molecular mechanisms using genomics, proteomics, lipidomics approaches in humans and model organisms.

Description of Itmat Expertise

Dr. Grosser's lab is interested in the integration of proteomic and genomic information to probe inflammatory and anti-inflammatory pathways in humans and model systems relevant to cardiovascular pathology and inflammatory pain.

Selected Publications

Theken KN, Grosser T: Weight-adjusted aspirin for cardiovascular prevention. Lancet 392(10145): 361-362, 2018.

Grosser T, Woolf CJ, FitzGerald GA: Time for nonaddictive relief of pain. Science 355(6329): 1026-1027, 2017.

Bhatt DL, Grosser T, Dong JF, Logan D, Jeske W, Angiolillo DJ, Frelinger AL 3rd, Lei L, Liang J, Moore JE, Cryer B, Marathi U.: Enteric Coating and Aspirin Nonresponsiveness in Patients With Type 2 Diabetes Mellitus. J Am Coll Cardiol 69(6): 603-612, 2017.

Grosser T, Theken KN, FitzGerald GA: Cyclooxygenase Inhibition: Pain, Inflammation, and the Cardiovascular System. Clin Pharmacol Ther 102(4): 611-622, 2017.

Greene CS, Krishnan A, Wong AK, Ricciotti E, Zelaya RA, Himmelstein DS, Zhang R, Hartmann BM, Zaslavsky E, Sealfon SC, Chasman DI, FitzGerald GA, Dolinski K, Grosser T, Troyanskaya OG.: Understanding multicellular function and disease with human tissue-specific networks. Nat Genet 47(6): 569-76, 2015.

Li X, Fries S, Li R, Lawson JA, Propert KJ, Diamond SL, Blair IA, FitzGerald GA, Grosser T: Differential impairment of aspirin-dependent platelet cyclooxygenase acetylation by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 111(47): 16830-5, 2014 Notes: [Open Access: http://www.pnas.org/content/111/47/16830.long]

Grosser T, Fries S, Lawson JA, Kapoor SC, Grant GR, FitzGerald GA: Drug Resistance and Pseudoresistance: An Unintended Consequence of Enteric Coating Aspirin. Circulation 127(3): 377-85, 2013 Notes: [Open Access: http://circ.ahajournals.org/content/127/3/377.full]

Lucitt MB, Price TS, Pizarro A, Wu W, Yocum AK, Seiler C, Pack MA, Blair IA, FitzGerald GA, Grosser T: Analysis of the zebrafish proteome during embryonic development. Mol Cell Proteomics 7(5): 981-94, 2008 Notes: [Cover image]

Price TS, Lucitt MB, Wu W, Austin DJ, Pizarro A, Yocum AK, Blair IA, Fitzgerald GA, Grosser T: EBP: Protein identification using multiple tandem mass spectrometry datasets. Mol Cell Proteomics 6: 527-536, 2007.

Fries S*, Grosser T* [* Co-First Authors], Price TS, Lawson JA, Kapoor S, DeMarco S, Pletcher MT, Wiltshire T, FitzGerald GA: Marked interindividual variability in the response to selective inhibitors of cyclooxygenase-2. Gastroenterology 130: 55-64, 2006.

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Last updated: 11/12/2018
The Trustees of the University of Pennsylvania