Bates Laboratory for the study of Host:Viral interactions                                             Perelman School of Medicine at the University of Pennsylvania



















Haines KM, Vande Burgt NH, Francica J, Kaletsky RL, Bates P. Chinese hamster ovary cell lines selected for resistance to ebolavirus glycoprotein mediated infection are defective for NPC1 expression. Virology. 2012 in press.




Francica JR, Varela-Rohena A, Medvec A, Plesa G, Riley JL, Bates P. Steric shielding of surface epitopes and impaired immune recognition induced by the ebola virus glycoprotein. PLoS Pathog. 2010 Sep 9;6(9):e1001098.  




Kaletsky RL, Francica JR, Agrawal-Gamse C, Bates P. Tetherin-mediated restriction of filovirus budding is antagonized by the Ebola glycoprotein. Proc Natl Acad Sci. 2009 Feb 24;106(8):2886-91.  




Francica JR, Matukonis MK, Bates P. Requirements for cell rounding and surface protein down-regulation by Ebola virus glycoprotein. Virology. 2009 Jan 20;383(2):237-47.  

News & Events



Ken finally updates website!!


Press release for MJ & Ken's paper!!


MJ & Ken's paper published in PLoS Pathogens!!


Ben Dyer joins the lab for his thesis work! Did I mention he also received an NSF award?! Go Ben!!


MJ Drake completes her prelim exam!


Alexa Nicolas graduates Penn & completes her thesis work!


Ken Briley presents a poster at the 2013 Viruses & Cells Gordon Italia!


Luis Cocka publishes his Tetherin work in PLoS Pathogens!



Kaletsky RL, Simmons G, Bates P. Proteolysis of the Ebola virus glycoproteins enhances virus binding and infectivity.

J Virol. 2007 Dec;81(24):13378-84.


Simmons G, Rennekamp AJ, Bates P. Proteolysis of SARS-associated coronavirus spike glycoprotein.

Adv Exp Med Biol. 2006;581:235-40.


Chai N, Bates P. Na+/H+ exchanger type 1 is a receptor for pathogenic subgroup J avian leukosis virus.

Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5531-6.


Amberg SM, Netter RC, Simmons G, Bates P. Expanded tropism and altered activation of a retroviral glycoprotein resistant to an entry inhibitor peptide.

J Virol. 2006 Jan;80(1):353-9.


Simmons G, Gosalia DN, Rennekamp AJ, Reeves JD, Diamond SL, Bates P. Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry.

Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11876-81.


Netter RC, Amberg SM, Balliet JW, Biscone MJ, Vermeulen A, Earp LJ, White JM, Bates P. Heptad repeat 2-based peptides inhibit avian sarcoma and leukosis virus subgroup a infection and identify a fusion

intermediate.J Virol. 2004 Dec;78(24):13430-9.


Simmons G, Reeves JD, Rennekamp AJ, Amberg SM, Piefer AJ, Bates P. Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry.

Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4240-5.


Simmons G, Rennekamp AJ, Chai N, Vandenberghe LH, Riley JL, Bates P. Folate receptor alpha and caveolae are not required for Ebola virus glycoprotein-mediated viral infection.

J Virol. 2003 Dec;77(24):13433-8.


Tanzi GO, Piefer AJ, Bates P. Equine infectious anemia virus utilizes host vesicular protein sorting machinery during particle release.

J Virol. 2003 Aug;77(15):8440-7.


Simmons G, Wool-Lewis RJ, Baribaud F, Netter RC, Bates P. Ebola virus glycoproteins induce global surface protein down-modulation and loss of cell adherence.

J Virol. 2002 Mar;76(5):2518-28.


Damico R, Bates P. Soluble receptor-induced retroviral infection of receptor-deficient cells.

J Virol. 2000 Jul;74(14):6469-75.


Balliet JW, Gendron K, Bates P. Mutational analysis of the subgroup A avian sarcoma and leukosis virus putative fusion peptide domain.

J Virol. 2000 Apr;74(8):3731-9. P


Damico R, Rong L, Bates P. Substitutions in the receptor-binding domain of the avian sarcoma and leukosis virus envelope uncouple receptor-triggered structural rearrangements in the surface and transmembrane subunits.

J Virol.1999 Apr;73(4):3087-94.


Balliet JW, Berson J, D'Cruz CM, Huang J, Crane J, Gilbert JM, Bates P. Production and characterization of a soluble, active form of Tva, the subgroup A  avian sarcoma and leukosis virus receptor.

J Virol. 1999 Apr;73(4):3054-61.


Wool-Lewis RJ, Bates P. Endoproteolytic processing of the ebola virus envelope glycoprotein: cleavage is not required for function.

J Virol. 1999 Feb;73(2):1419-26.


Rong L, Gendron K, Bates P. Conversion of a human low-density lipoprotein receptor ligandbinding repeat to a virus receptor: identification of residues important for ligand specificity.

Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8467-72.


Rong L, Gendron K, Strohl B, Shenoy R, Wool-Lewis RJ, Bates P. Characterization of determinants for envelope binding and infection in tva, the subgroup A avian sarcoma and leukosis virus receptor.

J Virol. 1998 Jun;72(6 :4552-9.


Damico RL, Crane J, Bates P. Receptor-triggered membrane association of a model retroviral glycoprotein.

Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2580-5.


Wool-Lewis RJ, Bates P. Characterization of Ebola virus entry by using pseudotyped viruses: identification of receptor-deficient cell lines.

J Virol. 1998 Apr;72(4):3155-60.  


Balliet JW, Bates P. Efficient infection mediated by viral receptors incorporated into retroviral particles.

J Virol. 1998 Jan;72(1):671-6.

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