Biochemistry and Molecular Biophysics Graduate Group

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General Requirements


Complete list of BMB courses
Relevant non-BMB courses
Sample Curricula

Fall 2015 courses
Spring 2016 courses
Fall 2016 Courses
Spring 2017 Courses
Fall 2017 Courses
Spring 2018 Courses
Fall 2018 Courses




The curriculum is designed to provide a superior graduate level education with a few core required courses and substantial flexibility in elective courses to tailor the program to each individual student's needs. Students are encouraged to choose electives that will round out their knowledge of biochemistry and molecular biophysics. A central goal is to build on the strengths and interests of each student and to prepare the student for dissertation research. By the end of the spring semester of their second year, each student should have achieved an understanding of biochemistry, molecular biology, and cell biology appropriate for a contemporary biomedical scientist. Substantial assistance in course selection is available to students from the Advising Committee.

General requirements

  1. Three Laboratory Rotations (BMB 699)
  2. BIOM 600 Cell Biology and Biochemistry - required (fall, first year).
  3. BMB 508 Macromolecular Biophysics: Principles and Methods - required (fall, first year).
  4. BMB 509 Structural and Mechanistic Biochemistry - required (spring, first year)
  5. BMB 705 Candidacy Exam Prep Course (½ credit)- required (spring, second year)
  6. BMB 510 Data Analysis and Scientific Inference (1 credit)- required (spring, first year)

Elective credits: Four (4) additional elective credits are required that may include formal lecture courses and seminars. These may be BMB or non-BMB classes.


Complete list of BMB courses

For a brief description of all BMB courses, click here

Lecture courses    
Course Number Title Course Director # of Credits
BMB 508 Macromolecular Biophysics: Principles and Methods Sharp 1
BMB 509 Structural and Mechanistic Biochemistry Van Duyne 1
BMB 518 Protein Conformational Diseases Argon / Ischiropoulos 1

BMB 554

BMB 560

Macromolecular Crystallagraphy: Methods and Applications

Methods of Scientific Inquiry in Biological Systems

Marmorstein/ Skordalakes

Wilson/ Domotor



BMB 567 Bioinorganic Chemistry Dmochowski 1
BMB 581 Techniques of Magnetic Resonance Imaging Song/ Wehrli 1
BMB 585 Wistar Institute Cancer Biology Course: Signaling Pathways in Cancer Skordalakes/ Murphy 1
BMB 601 Fundamentals of Magnetic Resonance Reddy ½

BMB 602

Imaging Biomarkers





BMB 618 Applications of High Resolution NMR Spectroscopy to Problems in Structural Biology Wand 1
BMB 619 Protein Folding   Axelsen / Englander ½
BMB 622 Mechano-Enzymes Dominguez/ Goldman/ Grishchuk/ Ostap ½
BMB 624 Molecular and Physical Basis of Ion Channels Kallen / Lu ½
BMB 626 Mass Spectrometry and Proteomics Speicher/ Garcia ½
BMB 627 Computer Programming for Biophysicists and Biochemists Sharp / Van Duyne ½
BMB 628 Principles of Scientific Instruments  Liebman ½
BMB 629 Quantitative Problems in Biochemistry and Biophysics Kallen ½
BMB 632

Probing Structure and Function of Complex RNA-Protein Machines

Lynch 1
BMB 751- 401 Selected Topics in Chemistry Petersson 1
Non-lecture courses    

BMB 598

BMB 650


Current Biochemical Topics (BMB student can take this twice; the course counts as an elective requirement only once)


Black / Shorter
BMB 699 Lab Rotation Kohli 1
BMB 705 Candidacy Exam Prep Class Marmorstein/ Lynch/ Nelson ½
BMB 799 Independent Study (Yrs 1-2) Staff ½ - 4

Relevant non-BMB courses

Many of the courses available to BMB students are taught in collaboration with other graduate programs. Topics covered by these courses are diverse. Students can choose from courses offered within Biomedical Graduate Studies, or from courses offered by graduate programs such as in Chemistry, Biology and Bioengineering. Many of these courses require course director permission to register. You are strongly encouraged to discuss your course selections with the BMB Advising Committee, during formal course advising sessions, or at any time.

Examples of non-BMB courses taken by current and past BMB students are given below with sample lecture outlines. It should be emphasized that this is not an exhaustive listing. A full listing of courses is described in the Course Register.

Note that courses which will be taught in Fall 2014 and which are courses that our students have taken over the past few years are marked with *. The Fall 2015 courses generally recommended for first year students and offered in Fall 2015 are marked with **.

* BE 554

Bioengineering Technology (F)
Advanced study of re DNA techniques; bioreactor design for bacteria, mammalian and insect culture; separation methods; chromatography; drug and cell delivery systems; gene therapy; and diagnostics.

* BE 699

Bioengineering Seminar (F)

* BIOL 437/ GCB 536

Introduction to Computational Biology & Biological Modeling (F)
Prerequisite(s): Intermediate level biology; MATH 104; BIOL 446 or equivalent.
Biology is flooded with data that cannot be understood without computational analysis and modeling. Computational Biology is a subfield of natural science where quantitative approaches are used to discover and understand biological and medical phenomena. The goal of this course is to develop a deep understanding of techniques and concepts used in Computational Biology. The course will strive to focus on a small set of approaches to gain both theoretical and practical issues such as programming and the use of programs, as well as theoretical issues such as algorithm design, statistical data analysis, theory of algorithms and statistics. Topics to be discussed include theory of computing, probability theory, multivariate statistics, molecular evolution, and network models. Grading is primarily based on 3 project reports

BIOM 502

Molecular Basis of Disease (Sp)
This course is reserved for BGS students only. BIOM 502 introduces students to basic mechanisms of disease and examines ~8 diseases in detail. The specific diseases chosen for discussion may vary year to year. The focus of the course will be on understanding the pathophysiology of the diseases and how research has enhanced not only our knowledge of disease mechanisms but has also led to improved therapy for patients with these diseases. Students will spend 1-2 weeks on each disease. Students will use materials from the medical school curriculum for background information and will use journal articles for class discussion

BIOM 520 Concepts and Methods in Biostatistics (Sum, 0.5 cu)
  This is an intensive 3-week, 0.5 CU summer course that is designed to introduce Biomedical Graduate Studies doctoral students to basic biostatistical methods and analyses. The class meets Monday through Friday morning for 90 minutes and includes both lectures and computer labs. Topics covered in the lectures include basic methods for describing data, the use of estimation and hypothesis testing, issues related to multiple comparisons and false detection, the use of parametric vs. nonparametric statistical methods and regression analysis. The focus of the computer lab will be to work on data analysis exercises using SAS software (or JMP for those who are Mac-based). Students will be able to analyze a small dataset of their own for their presentation.
BIOM 555 Control of Prokaryotic and Eukaryotic Gene Expression (Sp)
Regulation of gene expression including chromatin structure, transcription, DNA modification, RNA processing, translation, control of gene expression via microRNAs and post-translational processing.
** BIOL 446 Statistics for Biologists (F)
Prerequisite(s): MATH 104 or equivalent; or permission of instructor.
Introductory probability theory. Principles of statistical methods. Problems of estimation and
hypothesis testing in biology and related areas.
  This course covers introductory probability theory, principles of statistical methods, problems of estimation and hypothesis testing in biology and related areas.
BIOL 486 Chromosomes and the Cell Cycle (Sp)
Life depends on the propagation of genetic material from one generation to the next through cycles of genome replication and cell division. The genome is copied by the parent, and one exact copy is inherited by each daughter cell. We will treat chromosomes as discrete entities, rather than collections of genes, that are replicated and divided with high fidelity to ensure that the genome remains stable over many generations. By reading selected primary literature covering several decades, we will build an understanding of the cell cycle by focusing on chromosomes and the associated molecular machinery. We will explore mechanisms that underlie replication and division, particularly control mechanisms that maintain genome integrity and are critical to prevent disease. The goal of the course is to develop a picture of the cell cycle by examining some of the key experiments and insights that have led to our current understanding.
CAMB 512 Cancer Genetics and Biology (Sp)
  The course will involve lectures and readings of important papers on cancer genetics, cancer cell growth, metastasis, angiogenesis and experimental therapeutics.
CAMB/BIOL 526 Experimental Principles in Cell and Molecular Biology (F)
The course aims to introduce principles of current experimental techniques used in modern biology
CAMB 530 Seminar in Cell Cycle and Cancer (F)
  This seminar course will focus on molecular events that regulate cell cycle transitions and their relevance to human cancer. Topics will include control of the G1/S and G2/M transitions, relationships between tumor suppressor genes such as p16, Rb, p53 or oncogenes such as cyclin D, cdc25A, MDM2 or c-myc and cell cycle control. Where appropriate, the focus will be on understanding regulation of cell cycle control through transcriptional induction of gene expression, protein associations, posttranslational modifications like phosphorylation or regulation of protein stability like ubiquitin degradation. Although achieving an improved understanding of mammalian cancer is a goal of the course, much of our knowledge of the cell cycle derives from work done in more genetically tractable organisms, such as yeasts, drosophila, and xenopus.
**CAMB/ PHRM 532 Human Physiology (F)
  Prerequisite(s): Although noa formal prerequisite, a good foundation in cell biology at the level of BIOM/CAMB 600 (or an equivalent upper level undergraduate course) is strongly recommended. A general understanding oft he chemistry and biochemistry of macromolecules, and of basic molecular biology will also be assumed. This course is primarily designed for 2nd year BGS students; 1st year students in BGS or other programs will require the permission of the instructor. This course is not open to undergraduates. This course will present a survey of the physiology of most of the major organ systems. It will integrate knowledge of cellular and molecular mechanisms into an understanding of function at the tissue,organ, and organism levels. It will begin with a brief review of membrane physiology, followed by electrophysiology and signaling in nerve. Then, after a brief outline of neural control systems and their role in homeostasis, it will present motility and muscle, the cardiovascular system, respiration, the renal and gastrointestinal systems, and selected topics from the endocrine system, and there productive systems. As well as providing a basis of integrative physiology for students in fields such as physiology, bioengineering and pharmacology, it should be of interest to students of cellular and molecular biology and genetic engineering who will need to appreciate the roles of specific systems and molecules at higher levels of organization.
CAMB 534 Seminar on Current Genetic Research: Modeling Human Disease in Diverse Genetic Systems (Sp)
  An advanced seminar course emphasizing genetic research in model organisms and how it informs modern medicine. Each week a student will present background on a specific human disease. This is followed by an intense discussion by the entire class of ~2 recent papers in which model organisms have been used to address the disease mechanism and/or treatment. As a final assignment, students will have the opportunity to write, edit, and publish a "News & Views" style article in the journal "Disease Models and Mechanisms".
CAMB 548 Fundamentals in Virology
Basic course in virology including molecular, cellular, immunological, and in vivo pathological aspects.
**CAMB/ PHRM 542

Topics in Molecular Medicine (F)

Ti MM is planned as a once-weekly seminar course whose goal is to introduce students to the ways in
which biomedical research can provide new insights into clinical medicine and, conversely, how
knowledge of clinical disease impacts scientific discovery. There are two sections for the course -- 401
and 402. Section 401 is for first year MD/PhD students only and section 402 is for VMD/PhD and PhD

* CAMB 608

Regulation of Eukaryotic Gene Transcription (F)

Prerequisite(s): BIOM 555 or equivalent (exception=MD/PhD students). Students are expected
to bring their laptops to class. Non-CAMB students need approval from course instructors.
An advanced seminar course emphasizing the molecular biology and molecular gene expression in
eukaryotes. Based on the current literature, the presentations and discussions will familiarize the
student with present day technology and developing principles.

* CAMB 609

Vaccines and Immunization Therapy (F)
Prerequisites: Biology, biochemistry at the advanced college level, college level
immunology is recommended. Not limited to CAMB students, however first options are to CAMB
Vaccination is perhaps the most successful medical technological intervention. The goal of this course
is to expand on students' general understanding of the immune system and to focus this
understanding towards the application of vaccination and immune therapies for the 21 century.
Furthermore, the course will give the student a sense of how these principles are applied to vaccine
and immune therapeutic development. The course covers basic science as well as the clinical,
regulatory, ethical, and political issues and implications of modern vaccines and world health.
Initial lectures review immune mechanisms believed to be responsible for vaccine induced
protection from disease. Subsequent lectures build on this background to explore the science of
vaccines for diverse pathogens, including agents of bioterrorism as well as vaccines for cancer. An
appreciation for the application of laboratory science to the clinical development and studies of
vaccines is provided in the next section of the course along with lectures, which focus on the
regulatory, safety, and ethical implications of vaccines in different world situations. The financial
implications of specific vaccines on global health is one focus of the course.
The course is lecture style with many, many guest lecturers who are experts in their particular area
of vaccine development. There are required readings to provide the student context and background
for the diverse lectures topic. Students are graded on course participation, and a final project/exam.
The project is to design in a PowerPoint report a vaccine strategy for a current disease or pathogen of
importance that does not as yet have an effective vaccine or immune therapy. Strategies used should
build on the material presented in the class lectures. The course is intended for graduate students or
medical students in various MS, Ph.D., or MD/Ph.D. programs on the campus, as well as local
scientists and professionals in the community. As a prerequisite students should have taken biology,
biochemistry, or immunology courses at the advanced college level.

CAMB 610 Molecular Basis of Gene Therapy (F)
  This is a team-taught, survey course that focuses on the basic science relevant to achieving efficient and effective gene transfer in animal models and humans for the treatment of disease. The course includes a unit devoted to a variety of vectors useful for gene transfer, with the remainder of the course devoted to the study of current gene therapy approaches using specific diseases as models. Prior background in biochemistry, cell biology, and molecular biology is essential. Aspects of organ system anatomy and physiology, virology and immunology that are relevant to the course material are included in the course. Because of the rapid movement in this field, specific topics vary somewhat from year to year. The course is designed for second year graduate students, however first year students may take the course with the course director's approval. Lecture format with discussion hours interspersed. There will be a take-home examination at the end of each of the three sections, each focusing on the material covered in that section.
CAMB 691 Advanced Topics in Cell Biology and Physiology I (Sp, even years)

This course, together with its companion CAMB 692, offers an advanced, in depth analysis of selected topics in cell biology and physiology. CAMB 691 and 692 are complementary courses that focus on different aspects of cell biology; these courses are offered on an alternating basis in the spring semester. The courses can be taken in either order, but require BIOM 600 or an equivalent background in basic cell biology. CAMB 691 will focus on key issues at the forefront of research in the areas of (1) channels and transporters, (2) protein trafficking through cellular pathways, and (3) cytoskeletal dynamics and molecular motors. The course format pairs faculty presentations with student-led discussion sessions highlighting important papers from the primary literature.

CAMB 692 Advanced Topics in Cell Biology and Physiology II (Sp, odd years)

An in-depth consideration of key topics in cell biology and physiology. This course will focus on three major aspects: (1) signal transduction; (2) cell cycle and apoptosis; and (3) cell division. The course format will include both faculty lectures and student-led discussion sessions focusing on important papers from the primary literature.

**CAMB 698 Tutorial Electives in Cell Biology (F)
  Prerequisite(s): Cell 600 or an alternative senior undergraduate, graduate, or professional school course in Cell Biology.
This tutorial course is designed to provide students with an in-depth knowledge of a specific topic in
cell biology through directed readings with a faculty member. The tutorial can be used to enable
students to become more deeply acquainted with the literature related to their thesis projects or to
expand on another topic of interest.
CHEM 443 Modern Organic Reactions (F)
  Prerequisite(s): CHEM 241 and 242.
Introduction to advanced organic synthesis. Study of important synthetic reactions including:
oxidations, reductions, and methods for the formation of carbon-carbon bonds, with an emphasis in
chemoselectivity, stereoselectivity and asymmetric synthesis. Survey of modern methods for the
synthesis of small, medium and large ring systems. Analysis of modern synthetic strategies, with
illustrative examples from total synthesis of natural and unnatural products.
CHEM 521 Statistical Mechanics (F)
  Prerequisites: CHEM 222.
Principles of statistical mechanics with applications to systems of chemical interest. Principles of statistical mechanics with applications to systems of chemical interest.
CHEM 523 Quantum Chemistry I (F)
  Prerequisite(s): CHEM 222. The principles of quantum theory and applications to atomic systems.
** CHEM 525 Molecular Spectroscopy
  A modern introduction to the theory of the interaction of radiation and matter and the practice of molecular spectroscopy. Conventional microwave, magnetic resonance, optical, photoelectron, double-resonance, and laser spectroscopic techniques will be included.
CHEM 557 Mechanisms of Biological Catalysis

Reaction mechanisms in biological (enzymes, abzymes, ribozymes) and biomimetic systems with emphasis on principles of catalysis, role of coenzymes, kinetics, and allosteric control.

CIS 520 Machine Learning (F)
  Prerequisite(s): Elementary probability, calculus, and linear algebra. Basic programming experience.
This course covers the foundations of statistical machine learning. The focus is on probabilistic and
statistical methods for prediction and clustering in high dimensions. Topics covered include SVMs and
logistic regression, PCA and dimensionality reduction, and EM and Hidden Markov Models.
*ENM 510 Foundations of Engineering Mathematics (F)
  Prerequisite(s): MATH 240, MATH 241 or equivalent.
This is the first course of a two semester sequence, but each course is self contained. Over the two
semesters topics are drawn from various branches of applied mathematics that are relevant to
engineering and applied science. These include: Linear Algebra and Vector Spaces, Hilbert spaces,
Higher-Dimensional Calculus, Vector Analysis, Differential Geometry, Tensor Analysis, Optimization
and Variational Calculus, Ordinary and Partial Differential Equations, Initial-Value and Boundary-Value
Problems, Green's Functions, Special Functions, Fourier Analysis, Integral Transforms and Numerical
Analysis. The fall course emphasizes the study of Hilbert spaces, ordinary and partial differential
equations, the initial-value, boundary-value problem, and related topics.
* ESE 530 Elements of Probability Theory (F)
  Prerequisite(s): A solid foundation in undergraduate probability at the level of STAT 430 or ESE301 at Penn. Students are expected to have a sound calculus background as covered in the first two years of a typical undergraduate engineering curriculum. Undergraduates are warned that the course is very mathematical in nature with an emphasis on rigor; upperclassmen who wish to take the course will need to see the instructor for permission to register.
This rapidly moving course provides a rigorous development of fundamental ideas in probability theory
and random processes. This course is a prerequisite for subsequent courses in communication theory
and telecommunications such as ESE 576 and TCOM 501. The course is also suitable for students
seeking a rigorous graduate level exposure to probabilistic ideas and principles with applications in
diverse settings. We will focus on discrete and continuous probability spaces.
The topics covered are drawn from: abstract probability spaces; combinatorial probabilities;
conditional probability; Bayes's rule and the theorem of total probability; independence; connections
with the theory of numbers, Borel's normal law; rare events, Poisson laws, and the Lovasz local
lemma; arithmetic and lattice distributions arising from the Bernoulli scheme; limit laws and
characterizations of the binomial and Poisson distributions; continuous distributions in one and more
dimensions; the uniform, exponential, normal, and related distributions and their characterizations and
applications; random variables, distribution functions; random number generation and statistical tests
of randomness; measures of central tendency -- mean, median, mode; mathematical expectation and
the Lebesgue theory; expectations of functions, key properties, moments, convolutions; operator
methods and distributional convergence, the central limit theorem, selection principles; conditional
expectation; tail inequalities, concentration; convergence in probability and almost surely, the law of
large numbers, the law of the iterated logarithm; Poisson approximation, Janson's inequality, the Stein-Chen method; moment generating functions, renewal theory; characteristic functions.
GCB 531 Introduction to Genome Science
  This course serves as an introduction to the main laboratory and theoretical aspects of genomics and computational biology. The main topics discussed center around the analysis of sequences (annotation, alignment, homology, gene finding, variation between sequences, phylogeny reconstruction/estimation), and the functional analysis of genes (expression levels, proteomics, screens for mutants), together with a discussion of gene mapping, linkage disequilibrium, genetics of complex diseases, and integrative genomics.
* GCB 534 Experimental Genome Science (F)
  This course serves as an introduction to the main laboratory and theoretical aspects of genomics and computational biology. The main topics discussed center around the analysis of sequences (annotation, alignment, homology, gene finding, variation between sequences, phylogeny reconstruction/estimation), and the functional analysis of genes (expression levels, proteomics, screens for mutants), together with a discussion of gene mapping, linkage disequilibrium, genetics of complex diseases, and integrative genomics. 
GCB 535 Introduction to Bioinformatics (Sp)

This course provides a board overview of bioinformatics and computational biology as applied to biomedical research. Course material will be geared towards answering specific biological questions ranging from detailed analysis of a single gene through whole-genome analysis, transcriptional profiling, and systems biology. The relevant principles underlying these methods will be addressed at a level appropriate for biologists without a background in computational sciences. This course should enable students to integrate modern bioinformatics into their research program

** GCB/BE 567

Mathematical Computation Methods for Modeling Biological Systems (F)

This course will cover topics in systems biology at the molecular/cellular scale. The emphasis will be on quantitative aspects of molecular biology, with possible subjects including probabilistic aspects of DNA replication, transcription, translation, as well as gene regulatory networks and signaling. The class will involve analyzing and simulating models of biological behavior using MATLAB.



IMUN 506

Immune Mechanisms (F)

This is an introductory graduate course, which surveys most areas of immunology. It is assumed that students have a background in biochemistry and molecular biology, and at least some familiarity with immunological concepts.

**NGG 572 Neuroscience Core II. Electrical Language of Cells (F)
  This course introduces students to the high-speed electro-chemical signaling mechanisms that occur in nerve and other excitable cells during normal activity. Topics considered in substantial detail include: a) a fundamental description of the passive and active membrane electrical properties; b) the molecular architecture and functional role of ion channels in cell signaling; c) the role of the calcium ion as an ubiquitous chemical messenger, with applications to neuro- secretion; d) excitatory and inhibitory transmission in the central nervous system; e) sensory transduction, as illustrated by the visual, olfactory and auditory pathways. The course assumes a standard background in cell biology, as well as basic concepts from college physics and college calculus.
* NGG 587 Neurobiology of Disease (F)
  Prerequisite(s): Working knowledge of biology and chemistry. Corequisite(s): Permission of course director.
This course is designed to familiarize neuroscientists with basic information about a number of
important neurological and psychiatric disease, focusing on a relatively brief clinical description of the
condition and a more in depth discussion of what is currently understood about the basic pathobiology
of the disorder.
The course is divided into two parts: on Tuesday afternoons there will be a formal didactic teaching
session. The first part of each lecture (1/2 hour to 1 hour) will be devoted to a discussion of the
disease in question and the second part will consist of one or two student presentations (in lieu of a
paper or exam) reviewing in depth one critical neuroscience component of the disease. Each student
will work with the course director or an assigned faculty member to develop her/his lecture. On
Thursday afternoons, a faculty member will present a research seminar or chalk talk describing the
research she or he is conducting in that particular disease. Papers will be provided before the seminar
so the students will be familiar with the research. It is expected that having a research seminar given
after the introductory lecture
**PUBH 500 Introduction to Public Health (F)
  This course will provide a topical overview of the inter-disciplinary field of public health and provides
grounding in the public health paradigm. Through a series of lectures and recitation sessions,
students will learn about the history of public health and the core public health sciences including
behavioral and social sciences, biostatistics, epidemiology, environmental health, and policy and
management. Other topics include ethics in public health, context analyses (specifically sociographic
mapping and urban health), community participation in research, public health promotion, and the
prevention of chronic and infectious diseases.
* PHYS 611 Statistical Mechanics (F)
  Prerequisite(s): PHYS 401, 531, or equivalent.
Introduction to the canonical structure and formulation of modern statistical mechanics. The
thermodynamic limit. Entropic and depletion forces. Gas and liquid theory. Phase transitions and
critical phenomena. The virial expansion. Quantum statistics. Path integrals, the Fokker-Planck
equation and stochastic processes.
**PHYS 580

Biological Physics (Sp)

Prerequisite(s): MATH 240 and MATH 241 (or equivalent preparation), PHYS 401 or CHEM 221-222 (may be taken concurrently) or familiarity with basic statistical mechanics and thermodynamics. Recommended: Basic background in chemistry and biology.
A survey of basic biological processes at all levels of organization (molecule, cell, organism,
population) in the light of simple ideas from physics. Both the most ancient and the most modern
physics ideas can help explain emergent aspects of life, i.e., those which are largely independent of
specific details and cut across many different classes of organisms. Topics may include thermal
physics, entropic forces, free energy transduction, structure of biopolymers, molecular motors, cell
signaling and biochemical circuits, nerve impulses and neural computing, populations and evolution,
and the origins of life on Earth and elsewhere.


Sample Curricula (required courses are in bold)
All courses are 1 credit except as noted.





BIOM 600 Cell Biology and Biochemistry (1 cu)
BMB 508 Macromolecular Biophysics: Principles and Methods
(1 cu)
BMB 699 Lab Rotation 1
(1 cu)*
Elective (1 cu)


BMB 509 Structural and Mechanistic Biochemistry (1 cu)
BMB 510 Data Analysis and Scientific Inference (1 credit)
BMB 699 Lab Rotation 2 (1 cu)
Electives (1.5 cu)


BMB 699 Lab Rotation 3 (1 cu)
BMB 799 Independent Study or Tutorial or Lab Rotation 4 (3 cu total)



Electives or Independent Study (BMB 799) (4 cu)


BMB 705 Candidacy Examination Course (.5 cu)
Electives or Independent Study (3.5 cu)


Dissertation Research

* The first lab rotation may be taken in the summer if a student matriculates early.





Summer pre-Year 1

BMB 699 Lab Rotation 1
BMB 799 Independent Study


BIOM 600 Cell Biology
BMB 508 Macromolecular Biophysics: Principles and Methods

CHEM 441 Organic Mechanisms Structure
BMB 699 Lab Rotation 2


BMB 509 Structural and Mechanistic Biochemistry
BMB 626 Mass Spectrometry and Proteomics (½)
BMB 510 Data Analysis and Scientific Inference
CHEM 557 Mechanisms of Biological Catalysis
BMB 699 Lab Rotation 3


BMB 799 Independent Study



BMB 585 Wistar Institute Cancer Biology
BMB 611 Advanced X-ray methods (½)
BMB 630 Advanced Imaging (½)
BMB 799 Independent Study (2)


BMB 705 Candidacy Exam Prep (½)
BMB 650 Current Biochemical Topics (1)
BMB 799 Independent Study (2½)


Dissertation Research






BIOM 600 Cell Biology
BMB 508 Macromolecular Biophysics: Principles and Methods
BMB 633 Cellular Biochemistry and Biophysics
BMB 699 Lab Rotation 1


BMB 509 Structural and Mechanistic Biochemistry
BMB 560 Methods of Scientific Inquiry
BMB 510 Data Analysis and Scientific Inference (1 credit)
BMB 699 Lab Rotation 2
BMB 799 Independent Study (½ credit)



BMB 699 Lab Rotation 3
BIOM 520 Concepts & Methods in Biostatistics (½)
BMB 799 Independent Study



BMB 650 Current Biochemical Topics
BMB 619 Protein Folding (½)
CAMB 532 Human Physiology
BMB 799 Independent Study (1 ½)


BMB 705 Candidacy Exam Prep (½)
BMB 799 Independent Study (3 ½)


Dissertation Research





BIOM 600 Cell Biology
BMB 508 Macromolecular Biophysics: Principles and Methods

BIOL 446 Statistics for Biologists
BMB 699 Lab Rotation 1


BMB 509 Structural and Mechanistic Biochemistry
BMB 567 Bioinorganic Chemistry
BMB 622 Mechano-Enzymes (½)
BMB 510 Data Analysis and Scientific Inference (1 credit)
BMB 699 Lab Rotation 2


BMB 699 Lab Rotation 3
BMB 799 Independent Study



BMB 618 NMR in Structural Biology
CAMB 526 Exp. Principles in Cell & Molecular Biology
BMB 619 Protein Folding (½)
BMB 631 Redox Potentials & Electron Transfer (½)
BMB 799 Independent Study


BMB 705 Candidacy Exam Prep (½)
BMB 650 Current Biochemical Topics

799 Independent Study (2½)


Dissertation Research