Biochemistry and Molecular Biophysics Graduate Group

BMB Home » Faculty


A strength of the BMB program is its broad combination of faculty interests and disciplines. Faculty members are drawn from many departments in the Perelman School of Medicine, from other schools in the University, and from affiliated local research institutes. Although of many different affiliations, the faculty are unified by the pursuit of research and training activities that align with the mission of bmb.

FACULTY ALPHABETICALLY:                         


Control of gene expression and cellular programming
Baur Berger Bonasio Brass Busino Capelson Cherry Dreyfuss Fan Garcia Gardini Greenberg Grishchu Gupta Johnson Kohli Lakadamyali Lazar Lewis Little Lynch Marmorstein Murakami Murray Nelson Raj Shorter Song Song Speicher Van Duyne Wand Wellen Wilusz Wolfe Zaret Zhou

Cell signaling and intracellular trafficking
Abrams Argon Bennett Berger Black Brady Brass Brown Busino Capelson Chow Discher Dominguez Dreyfuss Fan Ferguson Garcia Goulian Greenberg Grishchuk Holzbaur Hua Kallen Kohli Lakadamyali Lampson Lee Lynch Marks Prosser Radhakrishnan Salzberg Song Song Titchenell Tran Wand Wilson Wolfe Zhou

Chemical and structural biology
Anna Argon Axelsen Baumgart Black Boesze-Battaglia Brady Brown Chow Dominguez Dunbrack Dutton Englander Fan Gai Goldman Greenberg Gupta Harvey Ischiropoulos Karanicolas Lee Lewis Marmorstein Murakami Nelson Ostap Patel Penning Petersson Radhakrishnan Rhoades Rubin Saven Sharp Shorter Skordalakes Song Speicher Tommos Van Duyne Wand Weisel Wilusz

Bioenergetics, metabolism, and membranes
Anna Axelsen Baur Daldal Discher Dutton Englander Goldman Kallen Lu Ostap Penning Radhakrishnan Rhoades Salzberg Sharp Song Speicher Titchenell Wand Weljie Wellen Wilson Witschey

Biomedical imaging and supramolecular assemblies
Anna Black Busch Chow Greenberg Harvey Lampson Lu Ostap Patel Reddy Rhoades Tran Tsourkas Vinogradov Wehrli Weisel Witschey



Charles S. Abrams, M.D. Phospholipid signaling in platelets and lymphocytes

Jessica M. Anna, Ph.D. Ultrafast multidimensional spectroscopy of natural light harvesting complexes and model systems

Yair Argon, Ph.D., Quality control of protein folding in the cell by molecular chaperones

Paul H. Axelsen, M.D., Protein misfolding diseases and pathological protein-lipid interactions; rational drug design

Tobias Baumgart, Ph.D., Biomembrane function: thermodynamics, dynamics and mechanics

Joseph A. Baur, Ph.D. Molecular mechanisms of aging and caloric restriction

Joel S. Bennett, M.D., Regulation of integrin function

Shelley L. Berger, Ph.D., Role of adaptors in regulation of transcriptional activation in yeast and humans

Ben E. Black, Ph.D., Chromosome segregation; chromatin structure; epigenetic centromere specification; hydrogen/deuterium exchange

Kathleen Boesze-Battagalia, Ph.D., Degradative processes including phagocytosis and autophagy contribute to cell homeostasis with defects leading to disease

Roberto Bonasio, Ph.D., Noncoding RNAs in chromatin biology and epigenetics.

Donita C. Brady, Ph.D., The research interests of our laboratory lie at the intersection of cancer biology, signal transduction, and metal homeostasis.

Lawrence Brass, M.D., Ph.D., Molecular basis for intracellular signaling in vascular biology

Eric J. Brown, Ph.D., Mechanisms that maintain genome stability during DNA replication

Theresa Busch, Ph.D., Photodynamic therapy, tumor microenvironment

Luca Busino, Ph.D., Mechanisms of protein ubiquitylation and degradation

Maya Capelson, Ph.D., Nuclear organization of chromatin and its role in gene regulation and cell differentiation

David Chenoweth, Ph.D., Development and application of synthetic methods for creating molecules that mimic or interact with biomolecules.

Sara Cherry, Ph.D., Genetic and mechanistic studies of viral-host interactions

Lewis A. Chodosh, M.D., Ph.D. Mouse models, cancer, oncogenes, targeted therapy, development, genomics, computational biology, stem cells, imaging

Brian Y. Chow, Ph.D., Photobiology and optogenetics

Fevzi Daldal, Ph.D., Genetics, structure-function, regulation and biogenesis of cytochromes

Scott L. Diamond, Ph.D., Mechanobiology, gene transfer, blood systems biology, drug discovery, protease chemical-biology.

Bohdana Discher Ph.D., Designing and interfacing proteins with membranes and electronic devices

Roberto Dominguez, Ph.D., Actin cytoskeleton, structural biology

Gideon Dreyfuss, Ph.D., Nuclear transport, hnRNP complexes, RNA-binding proteins, spinal muscular atrophy

Roland L. Dunbrack, Jr. Ph.D., Methods and applications of protein structure prediction

P. Leslie Dutton, Ph.D., Oxidoreductase engineering; design and chemical synthesis of redox proteins

S. Walter Englander, Ph.D., Protein folding; structure, structure change, and dynamics; H-exchange; NMR

Hua-Ying Fan, Ph.D. Regulation of chromatin structure and its impact on human diseases

Feng Gai, Ph.D., Spectroscopic study of protein folding/misfolding

Benjamin A. Garcia, Ph.D., Quantitative proteomics for understanding signaling pathways.

Alessandro Gardini, Ph.D. Understanding the role of enhancers and noncoding RNAs in transcriptional regulation in mammals.

Jerry Glickson, Ph.D., Molecular imaging: NMR spectroscopy and imaging of cancer; optical imaging of cancer; nanotechnology

Yale E. Goldman, M.D., Ph.D., Molecular motors and protein synthesis studied by single molecule biophysics

Mark Goulian, Ph.D., Two-component signaling, bacterial regulatory circuits

Roger Greenberg, M.D., Ph.D., Basic DNA repair mechanisms that impact cancer etiology and therapy

Kushol Gupta, Ph.D., Structural biology of large macromolecular assemblies that regulate genetic information; X-ray crystallography; small-angle X-ray and neutron scattering.

Ekaterina L. Grishchuk, Ph.D. Mechanisms that drive and control chromosome motions in mitosis

Stephen Harvey, Ph.D., Viral assembly; Origin of the ribosome; Nucleic acid structure and dynamics

Erika Holzbaur, Ph.D., Molecular motor-driven dynamics of organelles along the cellular cytoskeleton

Xianxin Hua, Ph.D., Signaling and epigenetic regulation of cell homeostasis and tumorigenesis

Harry Ischiropoulos, Ph.D., Biological chemistry of nitric oxide; oxidative processes, protein aggregation and neurodegeneration

Paul A. Janmey, Ph.D., Cytoskeleton, biopolymer mechanics, phosphoinositides

F. Bradley Johnson, M.D., Ph.D., Telomeres, chromatin, DNA repair and their interface with cell senescence and aging.

Roland G. Kallen, M.D., Ph.D., Structure, function, and regulation of expression of ion channel

John Karanicolas, Ph.D., Computational chemical biology and medicinal chemistry, rational drug design

Rahul M. Kohli, M.D., Ph.D., Investigating the enzymatic basis for diversity generation in the immune system and pathogens; enzyme mechanisms, chemical biology, protein evolution

Melike Lakadamyali, Ph.D. We study cytoskeleton and nuclear organization with super-resolution microscopy.

Michael Lampson, Ph.D., Chromosome segregation in mitosis and meiosis, biosensors for mitotic kinase

Mitchell Lazar, M.D., Ph.D., Nuclear receptors and the transcriptional regulation of metabolism

Virginia M.-Y. Lee, Ph.D., Pathobiology of Alzheimer's and Parkinson's disease

Mitchell Lewis, D.Phil., Gene regulation; protein crystallography; structural basis of recognition

Shawn C. Little, Ph.D., Transcription bursting dynamics; single molecule measurements; cell fate specification

Zhe Lu, M.D., Ph.D., Structure-function relationship of ion channels; molecular mechanisms of protein-protein interactions

Kristen W. Lynch, Ph.D., Mechanism and consequences of regulated alternative splicing

Michael S. Marks, Ph.D., Molecular mechanisms of intracellular protein transport and organelle biogenesis

Kenji Murakami, Ph.D., Transcription initiation and regulation in eukaryote.

Ronen Marmorstein, Ph.D., X-ray crystallography, chromatin regulation, tumor suppressors, oncoproteins, kinases, aging, structure-based inhibitor design

Maureen E. Murphy, Ph.D., The Murphy laboratory focuses on two tumor suppressor proteins that are commonly mutated in human cancer, p53 and p14ARF.

John I. Murray, Ph.D., Embryonic transcriptional regulation; fate specification; cell lineages; C. elegans; microscopy

Hillary C.M. Nelson, Ph.D., Structural biology; transcription; protein-DNA interactions; heat shock response

E. Michael Ostap, Ph.D., Biochemistry of contractile proteins, biophysics of cell motility, and characterization of unconventional myosins

Amish Patel, Ph.D., Predictive computational framework for characterizing biomolecular hydration, interactions and assemblies

Trevor M. Penning, Ph.D., Structure-function of aldo-keto reductases; role in steroid hormone action and chemical carcinogenesis

E. James Petersson, Ph.D., Semi-synthesis of labeled proteins to probe and control conformation

Benjamin L. Prosser, Ph.D., Mechano-signaling in the heart

Ravi Radhakrishnan, Ph.D., Computational structural biology and systems biology; cell membrane mediated trafficking; targeted drug delivery; cancer signaling

Arjun Raj, Ph.D., Systems biology; developmental biology; non-coding RNA

Frank J. Rauscher, Ph.D., Establishing, maintaining, and controlling differentiation of the stem cell niche in many diverse tissues is undoubtedly critical for mammalian development and homeostasis.

Ravinder Reddy, Ph.D., Sodium and oxygen-17 MR methods; multiple quantum and polarization transfer MR techniques

Rhoades, Elizabeth. Functional and dysfunctional mechanisms of intrinsically disordered proteins

Heinrich Roder, Ph.D., NMR; protein folding mechanism; protein structure, dynamics and function

Harvey Rubin, M.D., Ph.D., Pathogenesis of dormancy in mycobacterium tuberculosis; biomolecular computation and enzymology and cell biology of serine proteases and serine protease inhibitors

Brian M. Salzberg, Ph.D., Multiple-site optical recording; excitation-secretion coupling; neural networks

Jeffery G. Saven, Ph.D., Theory, simulation and design of proteins and folding molecules

Kim A. Sharp, Ph.D., Graduate Group Chair, Theory of protein and nucleic acid structure and function

James Shorter, Ph.D., Regulation of beneficial or neuropathogenic prions and amyloids by protein-remodeling factors, molecular chaperones, and small molecules

Emmanuel Skordalakes, Ph.D., X-ray crystallography; telomere biology; cancer and aging

Hongjun Song, Ph.D., Neurogenesis and Epigenetic/Epitranscriptomic Mechanisms in the Nervous System

Yuanquan Song, Ph.D., Studying the formation, maintenance and function of neural circuits

David Speicher, Ph.D., Cancer proteomics; structure-function of membrane associated proteins: protein chemistry and mass spectrometry

Alison Sweeney, Ph.D., Evolution of processes of self-assembly in bio-materials in optical function.

Paul M. Titchenell, Ph.D., Molecular mechanisms of insulin signaling and insulin resistance.

Cecilia Tommos, Ph.D., Protein radicals and electrochemistry; cation-x interactions; protein forced folding

Phong Tran, Ph.D., Cytoskeleton organization and cellular pattern formation

Andrew Tsourkas, Ph.D. Molecular imaging, drug delivery, nanotechnology, and biotherapeutics

Gregory D. Van Duyne, Ph.D., Structural biology; protein-protein interactions; x-ray crystallography

Sergei A. Vinogradov, Ph.D., Functional macromolecules, optical imaging probes, porphyrin chemistry, dendrimer chemistry, oxygen microscopy and tomography

A. Joshua Wand, Ph.D., Protein structure and dynamics; molecular recognition and signal transduction; NMR spectroscopy

Felix W. Wehrli, Ph.D., MRI of biomaterials microstructure, mathematical modeling, image processing

John W. Weisel, Ph.D., Structural studies of molecular/cellular mechanisms in blood clotting and fibrinolysis

Aalim Weljie, Ph.D., Circadian, sleep, environmental and cancer metabolism via metabolomics profiling

Kathryn E. Wellen, Ph.D., Cancer cell metabolism, nutrient sensing

David F. Wilson, Ph.D., Integration of metabolism; oxidative phosphorylation; neuroregulation

Jeremy E. Wilusz, Ph.D., Regulation of noncoding RNA biogenesis and function

Walter Witschey, Ph.D. Study of cardiovascular disease using imaging and computational biology.

John H. Wolfe, V.M.D., Ph.D., Lysosomal enzymes; storage diseases; gene transfer into brain; CNS genomics/proteomics.

Xiaolu Yang, Ph.D., Molecular mechanisms of apoptosis and how they may relate to cancer and other diseases.

Kenneth S. Zaret, Ph.D., Investigating transcription factor interactions with chromatin

Zhaolan (Joe) Zhou, Ph.D., Epigenetic control of genome function in brain development and disease