The 19th annual BPC Postdoctoral Research Symposium will take place virtually on Thursday, January 28th and Friday, January 29th, 2021. Our keynote speakers are Drs. James Alvarez and Jill Turner. A detailed schedule will be posted closer to the date.
About the Photo
This year's symposium art image was created by Natasha Jaiswal, Ph.D., Department of the Institute for Diabetes, Obesity and Metabolism in the Perelman School of Medicine at the University of Pennsylvania.
Role of skeletal muscle insulin signaling in NMJ remodeling
The neuromuscular junction (NMJ) is a complex structure that mediates the cross-talk between motor neurons and muscle fibers, serving as the master controller of many facets of skeletal muscle contractile function. Accordingly, defects in NMJ function result in physio-pathologic conditions including sarcopenia and Amyotrophic Lateral Sclerosis (ALS). Therefore, it is important to identify factors that function to maintain the structural integrity of NMJs. Our study identifies that loss of skeletal muscle insulin signaling alters NMJ morphology, characterized by irregular and fragmented NMJ (red pretzel like structure labelled with post synaptic nicotinic acetylcholine receptor (nAChR) antibody. This was associated with reduced NMJ density and sprouting of motor neurons (labelled green).