The 18th annual BPC Postdoctoral Symposium will be held on October 11th, 2019, in the Smilow Center for Translational Research. Registration and abstract submission are now open. Our keynote speaker is Dr. Richard White. A detailed schedule will be posted closer to the date.
About the Photo
This year's symposium art image was created by Valerie Tutwiler, Ph.D. in the Department of Cell and Developmental Biology at the University of Pennsylvania.
Clot contraction drives structural redistribution of platelets, fibrin and red blood cells through energy minimization
Blood clot contraction, or the volume shrinkage of the clot, plays a critical role in the restoration of blood flow past otherwise obstructive thrombi. Contraction is driven by platelet (yellow) generated contractile forces, which are propagated through the fibrin network (blue). We show that this results in the redistribution of fibrin to the exterior of the clot and the compression of erythrocytes (red) into polyhedron-like shapes. Coupled experimental results with a computational model revealed that energy minimization drives this structural redistribution. The structural redistribution of contracting clots observed here provides a potential basis for the decrease in efficacy of thrombolytic treatment with increasing time following symptom onset and has implications for the development of novel thrombolytics.