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Introduction and Welcome Remarks

Leveraging macrophage activation in metastatic ovarian cancer

Engineering synthetic receptors to direct macrophage cell state

Elimination of pathogenic B cells and autoantibodies in systemic lupus erythematosus using CAR T cells against IGHV4-34 B cell receptor

Synthetic biology for ophthalmic gene therapy

Come back to the meeting room for the poster blitz!

Lobby. All presenters should be at their posters for the duration of the session.

Correction of a recurrent pathogenic variant in methylmalonic acidemia using adenine base editing

Base and prime editing to correct the most common non-deletional mutation in alpha thalassemia

Targeting glial cells for remyelination

Direct base editing of the HTT repeat mimics protective Huntington's disease alleles attenuating somatic expansion

Engineering an mRNA vaccine against measles

Precision PROTAC therapy for a genetic disease

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Cancer-associated Smarca4 mutations augment CD8 T cell responses against infection and cancer

Role of IFN-gamma in maintaining microglial reactivity during resolution of infection

Metabolomic profiling informs nutrient supplementation strategies to mitigate CAR T cell exhaustion

Investigating the role of IL-1 signaling in reactogenicity and immunogenicity of clinical mRNA-LNP vaccines in mice

Barry J. Gertz Professor for Translational Research · Co-Director, Orphan Disease Center, Penn Medicine and Children's Hospital of Philadelphia · Director, Genetic and Epigenetic Origins of Disease Program, Penn Cardiovascular Institute

Therapeutic gene editing for cardiovascular and metabolic diseases

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