Spyridon (Spyros) Bakas, Ph.D.

Assistant Professor (Tenure Track)

Spyridon Bakas, Ph.D.Dept. of Pathology & Laboratory Medicine
Dept. of Radiology (joint appt)
Dept. of Bioengineering (secondary appt)
Perelman School of Medicine
University of Pennsylvania
Medical Research Analytics for Quantitative Integration (MeRAQI) lab - Director
Artificial Intelligence in Biomedical Imaging Lab (AIBIL)
Center for AI & Data Science for Integrated Diagnostics (AI2D) - Executive Faculty Committee
Center for Biomedical Image Computing & Analytics (CBICA)

Google Scholar  |  LinkedIn  |  Twitter  |  GitHub

Contact:

Richards Medical Research Labs, Fl7, St.A702
3700 Hamilton Walk
Philadelphia, PA 19104
Email

Research Summary

My research interest focuses on the development, application, and benchmarking of advanced computational algorithms in oncological imaging, with the intention of improving the assessment, quantification, and diagnosis of cancer in the current clinical practice. Eagerly embracing the concept of personalized/precision medicine, I am involved in radio-patho-genomic research where correlations between quantitative imaging features and molecular characteristics can lead to highly accurate imaging biomarkers, towards enabling treatment selection models customized on an individual patient basis. I have also been leading federated machine learning efforts in healthcare towards facilitating expedited multi-institutional studies, while patient data are always retained within the acquiring institution. My work so far has spanned across the areas of image segmentation, feature extraction, statistical analysis, motion analysis, and machine learning techniques applied in magnetic-resonance (MR), digitized histopathology, and contrast-enhanced ultrasound (CEUS), imaging data. The ultimate aim of my research is clinical deployment, towards making diagnostic and treatment decisions more promptly, objectively, and precisely.

Educational Qualifications

Ph.D. in Medical Image Computing & Analysis - Kingston University, London (UK)
M.Sc. in Vision, Imaging & Virtual Environments - University College London (UK)
B.Sc. (Hons) in Computer Science - Kingston University, London (UK)

My News

 

Published Material

(for a complete up to date list of publications, please visit my Google scholar page)

* denotes equal contribution

  1. Linmin Pei, Spyridon Bakas, Arastoo Vossough, Syed M.S. Reza, Christos Davatzikos, Khan M. Iftekharuddin, “Longitudinal brain tumor segmentation prediction in MRI using feature and label fusion”, Biomedical Signal Processing and Control, 55, 2020.
    DOI: 10.1016/j.bspc.2019.101648
  2. Saima Rathore*, Hamed Akbari*, Spyridon Bakas, Jared M. Pisapia, Gaurav Shukla, Jeffrey D. Rudie, Xiao Da, Donald M. O’Rourke, Christos Davatzikos, “Multivariate Analysis of Preoperative Magnetic Resonance Imaging Reveals Transcriptomic Classification of de novo Glioblastoma Patients”, Frontiers in Computational Neuroscience, 2019.
    DOI: 10.3389/fncom.2019.00081
  3. Anahita Fathi Kazerooni, Spyridon Bakas, Hamidreza Saligheh, Christos Davatzikos, “Imaging signatures of glioblastoma molecular characteristics: A radiogenomics review”, Journal of Magnetic Resonance Imaging. 2019.
    DOI: 10.1002/jmri.26907
  4. Spyridon Bakas, Michael Feldman, “Computational staining of unlabelled tissue”, Nature Biomedical Engineering, 3:425-426, 2019.
    DOI: 10.1038/s41551-019-0414-3
  5. Christos Davatzikos*, Aristeidis Sotiras*, Yong Fan*, Mohamad Habes*, Guray Erus*, Saima Rathore*, Spyridon Bakas*, Rhea Chitalia*, Aimilia Gastounioti*, Despina Kontos*, “Precision diagnostics based on machine learning-derived imaging signatures”, Magnetic Resonance Imaging, 64:49-61, 2019.
    DOI: 10.1016/j.mri.2019.04.012
  6. Spyridon Bakas, Matthaios Doulgerakis-Kontoudis, Gordon J.A. Hunter, Katerina Chatzimichail, Paul S. Sidhu, Dimitrios Makris, “Evaluation of Indirect Methods for Motion Compensation in 2D Focal Liver Lesion Contrast-Enhanced Ultrasound (CEUS) Imaging”, Ultrasound in Medicine & Biology, 45(6):1380-1396, 2019.
    DOI: 10.1016/j.ultrasmedbio.2019.01.023
  7. Zev A. Binder*, Amy Haseley Thorne*, Spyridon Bakas*, E. Paul Wileyto, Michel Bilello, Hamed Akbari, Saima Rathore, Sung Min Ha, Logan Zhang, Cole J. Ferguson, Sonika Dahiya, Wenya Linda Bi, David A. Reardon, Ahmed Idbaih, Joerg Felsberg, Bettina Hentschel, Michael Weller, Stephen J. Bagley, Jennifer J.D. Morrissette, MacLean P. Nasrallah, Jianhui Ma, Ciro Zanca, Andrew M. Scott, Laura Orellana, Christos Davatzikos, Frank B. Furnari, Donald M. O’Rourke, "Epidermal Growth Factor Receptor Extracellular Domain Mutations in Glioblastoma Present Opportunities for Clinical Imaging and Therapeutic Development", Cancer Cell, 34(1):163-177, 2018.
    DOI: 10.1016/j.ccell.2018.06.006
  8. Xu Han, Roland Kwitt, Stephen Aylward, Spyridon Bakas, Bjoern Menze, Alexander Asturias, Paul Vespa, John Van Horn, Marc Niethammer, "Brain Extraction from Normal and Pathological Images: A Joint PCA/Image-Reconstruction Approach", Neuro-Image, 176:431-445, 2018.
    DOI: 10.1016/j.neuroimage.2018.04.073.
  9. Hamed Akbari*, Spyridon Bakas*, Jared Pisapia, MacLean P Nasrallah, Martin Rozycki, Maria Martinez-Lage, Jennifer J D Morrissette, Nadia Dahmane, Donald M O’Rourke, Christos Davatzikos. "In vivo evaluation of EGFRvIII mutation in primary glioblastoma patients via complex multi-parametric MRI signature", Neuro Oncology, 20(8):1068-1079, 2018.
    DOI: 10.1093/neuonc/noy033
  10. Jared M. Pisapia, Hamed Akbari, Martin Rozycki, Hannah Goldstein, Spyridon Bakas, Saima Rathore, Julie S. Moldenhauer, Phillip B. Storm, Deborah M. Zarnow, Richard C.E. Anderson, Gregory G. Heuer, Christos Davatzikos, “Predicting Need for Post-Natal Cerebrospinal Fluid Diversion in Fetal Ventriculomegaly using Fetal Magnetic Resonance Image Analysis and Machine Learning”, JAMA Pediatrics, 172(2):128-135, 2018.
    DOI: 10.1001/jamapediatrics.2017.3993
  11. Gaurav Shukla, Gregory S Alexander, Spyridon Bakas, Rahul Nikam, Kiran Talekar, Joshua D. Palmer, Wenyin Shi, "Advanced Magnetic Resonance Imaging in Glioblastoma: A Review", JHN Journal, 13(1):30-34, 2018.
    DOI: 10.29046/JHNJ.013.1.005
  12. Christos Davatzikos, Saima Rathore, Spyridon Bakas, Sarthak Pati, Mark Bergman, Ratheesh Kalarot, Patmaa Sridharan, Aimilia Gastounioti, Nariman Jahani, Erik Cohen, Hamed Akbari, Birkan Tunc, Jimit Doshi, Drew Parker, Michael Hsieh, Aristeidis Sotiras, Hongming Li, Yangming Ou, R.K.Doot, Michel Bilello, Yong Fan, Russell T. Shinohara, Paul Yushkevich, Ragini Verma, Despina Kontos, “Cancer Imaging Phenomics Toolkit: Quantitative Imaging Analytics for Precision Diagnostics and Predictive Modeling of Clinical Outcome”, Journal of Medical Imaging: Special Section on Quantitative Imaging Methods and Translational Developments – Honoring the Memory of Dr. Larry Clarke, 5(1):0110118, 2018.
    DOI:  10.1117/1.JMI.5.1.011018
  13. Spyridon Bakas, Hamed Akbari, Aristeidis Sotiras, Michel Bilello, Martin Rozycki, Justin S. Kirby, John B. Freymann, Keyvan Farahani, Christos Davatzikos. "Advancing The Cancer Genome Atlas glioma MRI collections with expert segmentation labels and radiomic features", Nature Scientific Data, 4:170117, September 5 2017.
    DOI: 10.1038/sdata.2017.117
    (Publisher's version)
  14. Spyridon Bakas, Hamed Akbari, Jared Pisapia, Maria Martinez-Lage, Martin Rozycki, Saima Rathore, Nadia Dahmane, Donald M. O’Rourke, Christos Davatzikos. "In vivo detection of EGFRvIII in glioblastoma via perfusion magnetic resonance imaging signature consistent with deep peritumoral infiltration: the φ index", Clin Cancer Research, 23(16):4724-4734, August 15 2017.
    DOI: 10.1158/1078-0432.CCR-16-1871
    (Publisher's version)
  15. Gaurav Shukla, Gregory S. Alexander, Spyridon Bakas, Rahul Nikam, Kiran Talekar, Joshua D. Palmer, Wenyin Shi, "Advanced magnetic resonance imaging in glioblastoma: a review", Chin Clin Oncol, 6(4):40, August 04 2017.
    DOI:10.21037/cco.2017.06.28
    (Publisher's version)
  16. Spyridon Bakas, Dimitrios Makris, Gordon J.A. Hunter, Cheng Fang, Paul S. Sidhu, Katerina Chatzimichail. "Automatic Identification of the Optimal Reference Frame for Segmentation and Quantification of Focal Liver Lesions in Contrast-Enhanced Ultrasound", Ultrasound in Medicine & Biology, 43(10):2438–2451, 2017.
    DOI: 10.1016/j.ultrasmedbio.2017.06.005
  17. Jared M. Pisapia, Martin Rozycki, Hamed Akbari, Spyridon Bakas, Jayesh P. Thawani, Julie S. Moldenhauer, Phillip B. Storm, Deborah M. Zarnow, Christos Davatzikos, Gregory G. Heuer. "Correlations of Atrial Diameter and Fronto-Occipital Horn Ratio with Ventricle Size in Fetal Ventriculomegaly", Journal of Neurosurgery: Pediatrics, 19(3):300-306, 2017.
    DOI: 10.3171/2016.9.PEDS16210
    (Publisher's version)
  18. Spyridon Bakas, Katerina Chatzimichail, Gordon Hunter, Bastien Labbe, Paul S. Sidhu, Dimitrios Makris, "Fast Semi-Automatic Segmentation of Focal Liver Lesions in Contrast-Enhanced Ultrasound, Based on a Probabilistic Model", TCIV Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization, 5(5):329:338, 2017.
    DOI: 10.1080/21681163.2015.1029642
    (View Preprint)  —  (Publisher's Version)
  19. Spyridon Bakas, Katerina Chatzimichail, Andreas Hoppe, Vasileios Galariotis, Gordon Hunter, Dimitrios Makris, "Histogram-based Motion Segmentation and Characterisation of Focal Liver Lesions in CEUS", Annals of the BMVA (Special Issue), 2012.
    (Published Version)

  1. Saima Rathore, Hamed Akbari, Spyridon Bakas, Jared Pisapia, Xiao Da, Donald M. O’Rourke, Christos Davatzikos , “Non-invasive transcriptomic classification of de novo Glioblastoma patients through multivariate quantitative analysis of baseline preoperative multimodal magnetic resonance imaging”, Medical Imaging 2019: Computer-Aided Diagnosis, 10950, 2019.
    DOI: 10.1117/12.25128372.
  2. Micah J. Sheller, G. Antony Reina, Brandon Edwards, Jason Martin, Spyridon Bakas, “Multi-Institutional Deep Learning Modeling Without Sharing Patient Data: A Feasibility Study on Brain Tumor Segmentation”, Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries, Springer, LNCS, 11383:92-104, 2019.
    DOI: 10.1007/978-3-030-11723-8_93.
  3. Samar S. M. Elsheikh, Spyridon Bakas, Nicola J. Mulder, Emile R. Chimusa, Christos Davatzikos, Alessandro Crimi, “Multi-Stage Association Analysis of Glioblastoma Gene Expressions with Texture and Spatial Patterns”, Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries, Springer, LNCS, 11383:239-250, 2019.
    DOI: 10.1007/978-3-030-11723-8_244.
  4. Xu Han, Spyridon Bakas, Roland Kwitt, Stephen Aylward, Hamed Akbari, Michel Bilello, Christos Davatzikos, Marc Niethammer, “Patient-Specific Registration of Pre-Operative and Post-Recurrence Brain Tumor MRI Scans”, Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries, Springer, LNCS, 11383:105-114, 2019.
    DOI: 10.1007/978-3-030-11723-8_105
  5. Saima Rathore, Spyridon Bakas, Hamed Akbari, Gaurav Shukla, Martin Rozycki, Christos Davatzikos, "Deriving stable multi-parametric MRI radiomic signatures in the presence of inter-scanner variations: survival prediction of glioblastoma via imaging pattern analysis", Medical Imaging 2018:Computer-Aided Diagnosis 10575, 1057509, 2018.
    DOI: 10.1117/12.2293661
  6. Saima Rathore, Spyridon Bakas, Sarthak Pati, Hamed Akbari, Ratheesh Kalarot, Patmaa Sridharan, Martin Rozycki, Mark Bergman, Birkan Tunc, Ragini Verma, Michel Bilello, Christos Davatzikos, “Brain Cancer Imaging Phenomics Toolkit (brain-CaPTk): An Integrative Platform for Quantitative Analysis of Glioblastoma”, Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries, Springer, LNCS, 10670:133-145, 2018.
    DOI: 10.1007/978-3-319-75238-9_12
  7. Ke Zeng, Spyridon Bakas, Aristeidis Sotiras, Hamed Akbari, Martin Rozycki, Saima Rathore, Sarthak Pati, Christos Davatzikos. "Segmentation of Gliomas in Pre-Operative and Post-Operative Multimodal Magnetic Resonance Imaging Volumes Based on a Hybrid Generative-Discriminative Framework", Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries, Springer, LNCS, 10154:184-194, 2017.
    DOI: 10.1007/978-3-319-55524-9_18
    (Athens, Greece, 17-21 Oct 2016)
  8. Ke Zeng, Spyridon Bakas, Aristeidis Sotiras, Hamed Akbari, Martin Rozycki, Saima Rathore, Sarthak Pati, Christos Davatzikos. "Segmentation of Gliomas in Pre-Operative and Post-Operative Multimodal Magnetic Resonance Imaging Volumes Based on a Hybrid Generative-Discriminative Framework", In Proceedings of the Multimodal Brain Tumor Image Segmentation Challenge held in conjunction with MICCAI 2016 (MICCAI-BRATS 2016).
    (Athens, Greece, 17-21 Oct 2016)
  9. Spyridon Bakas, Ke Zeng, Aristeidis Sotiras, Saima Rathore, Hamed Akbari, Bilwaj Gaonkar, Martin Rozycki, Sarthak Pati, Christos Davatzikos. "GLISTRboost: Combining Multimodal MRI Segmentation, Registration, and Biophysical Tumor Growth Modeling with Gradient Boosting Machines for Glioma Segmentation", Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries, Springer, LNCS, 9556:144-155, 2016.
    DOI: 10.1007/978-3-319-30858-6_13
    (Technische Universität München (T.U.M.), Munich, Germany, 5-9 Oct 2015)
    (Publisher's Version)
  10. Spyridon Bakas, Ke Zeng, Aristeidis Sotiras, Saima Rathore, Hamed Akbari, Bilwaj Gaonkar, Martin Rozycki, Sarthak Pati, Christos Davatzikos. "Segmentation of Gliomas in Multimodal Magnetic Resonance Imaging Volumes Based on a Hybrid Generative-Discriminative Framework", In Proceedings of the Multimodal Brain Tumor Image Segmentation Challenge held in conjunction with MICCAI 2015 (MICCAI-BRATS 2015).
    (Technische Universität München (T.U.M.), Munich, Germany, 5-9 Oct 2015)
  11. Spyridon Bakas, Katerina Chatzimichail, Paul Sidhu, Dimitrios Makris. "Automatic Identification and Localisation of Potential Malignancies in Contrast-Enhanced Ultrasound Liver Scans Using Spatio-Temporal Features", 6th MICCAI Workshop on Abdominal Imaging - Computational and Clinical Applications, Springer, LNCS, 8676:13-22, 2014.
    DOI: 10.1007/978-3-319-13692-9_2
    (Massachusetts Institute of Technology (M.I.T.), Boston, U.S.A., 14-18 Sep 2014)
    (View)  —  (Publisher's Version)
  12. Spyridon Bakas, Bastien Labbe, Gordon J.A. Hunter, Paul Sidhu, Katerina Chatzimichail, Dimitrios Makris. "Fast Segmentation of Focal Liver Lesions in Contrast-Enhanced Ultrasound Data", In Proceedings of the 18th Annual Conference on Medical Image Understanding and Analysis (MIUA), 73-78, 2014.
    DOI: 10.13140/2.1.1769.0400
    (London, U.K., 9-11 Jul 2014)
    (View)  —  (Publisher's Version)
  13. Spyridon Bakas, Bastien Labbe, Gordon J.A. Hunter. "Making the Best Use of Fifty (or more) Shades of Gray: Intelligent Contrast Optimisation for Image Segmentation in False-Colour Video", 10th International Conference on Intelligent Environments - IE'14, IEEE, 218-221, 2014.
    DOI: 10.1109/IE.2014.41
    (Shanghai, China, 30 Jun-4 Jul 2014)
    (View)  —  (Publisher's Version)
  14. Spyridon Bakas, Paul Sidhu, Maria Sellars, Gordon J.A. Hunter, Dimitrios Makris, Katerina Chatzimichail. "Non-Invasive Offline Characterisation of Contrast-Enhanced Ultrasound Evaluations of Focal Liver Lesions: Dynamic Assessment Using a New Tracking Method", 20th European Congress of Radiology, European Society of Radiology, 2014.
    DOI: 10.1594/ecr2014/C-1378
    (Vienna, Austria, 6-10 Mar 2014)
    (View)  —  (Publisher's Version)
  15. Spyridon Bakas, Gordon J.A. Hunter, Celia Thiebaud, Dimitrios Makris. "Spot the Best Frame: Towards Intelligent Automated Selection of the Optimal Frame for Initialisation of Focal Liver Lesion Candidates in Contrast Enhanced Ultrasound Video Sequences",9th International Conference on Intelligent Environments - IE'13, IEEE, 196-203, 2013.
    DOI: 10.1109/IE.2013.20
    (Athens, Greece, 18-19 Jul 2013)
    (View)  —  (Publisher's version)
  16. Spyridon Bakas, Katerina Chatzimichail, Andreas Hoppe, Vasileios Galariotis, Gordon Hunter, Dimitrios Makris. "Focal Liver Lesion Tracking in CEUS for Characterisation based on Dynamic Behaviour", Springer, Advances in Visual Computing, 8th International Symposium on Visual Computing (ISVC), LNCS, 7431:32-41, 2012.
    DOI: 10.1007/978-3-642-33179-4_4
    (Crete, Greece, 16-18 July 2012)
    (View)  —  (Publisher's version)
  17. Spyridon Bakas, Katerina Chatzimichail, Awen Autret, Andreas Hoppe, Vasileios Galariotis, Dimitrios Makris. "Localisation and characterisation of focal liver lesions using contrast-enhanced ultrasonographic visual cues", In Proceedings of the 15th Annual Conference on Medical Image Understanding and Analysis (MIUA), 2011.
    DOI: 10.13140/2.1.1474.1280
    (London, U.K., 14 - 15 July 2011)
    (View)  —  (Publisher's version)

* denotes equal contribution

  1. Zev A. Binder*, Amy Haseley Thorne*, Spyridon Bakas*, E. Paul Wileyto, Hamed Akbari, Saima Rathore, Sung Min Ha, Logan Zhang, Ahmed Idbaih, Stephen J. Bagley, Jennifer J.D. Morrissette, MacLean P. Nasrallah, Jianhui Ma, Ciro Zanca, Andrew M. Scott, Christos Davatzikos, Frank B. Furnari, Donald M. O’Rourke, “Epidermal Growth Factor Receptor extracellular domain missense mutant A289V as a driver of glioblastoma invasion and proliferation”, Neuro-Oncology, 20(suppl_6):vi48-vi48, 2018.
    DOI: 10.1093/neuonc/noy148.191
  2. Spyridon Bakas*, Saima Rathore*, MacLean Nasrallah*, Hamed Akbari, Zev Binder, Sung Min Ha, Elizabeth Mamourian, Jennifer J.D. Morrissette, Donald M. O’Rourke, Christos Davatzikos, “Non-invasive in vivo signature of IDH1 mutational status in high grade glioma, from clinically-acquired multi-parametric magnetic resonance imaging, using multivariate machine learning”, Neuro-Oncology, 20(suppl_6):vi184-vi185, 2018.
    DOI: 10.1093/neuonc/noy148.766
  3. Saima Rathore*, Spyridon Bakas*, MacLean P. Nasrallah*, Hamed Akbari, Stephen J. Bagley, Sing Min Ha, Elizabeth C. Mamourian, Christopher Watt, Zev Binder, Donald M. O’Rourke, Christos Davatzikos, “Multivariate pattern analysis of de novo glioblastoma patients offers in vivo evaluation of O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation status, compensating for insufficient specimen and assay failures”, Neuro-Oncology, 20(suppl_6):vi186-vi186, 2018.
    DOI: 10.1093/neuonc/noy148.771
  4. Hamed Akbari, Saima Rathore, Spyridon Bakas, MacLean Nasrallah, Martin Rozycki, Suyash Mohan, Ronald Wolf, Michel Bilello, Maria Martinez-Lage, Christos Davatzikos, “Quantitative image analysis and machine learning techniques for distinguishing true progression from pseudoprogression in patients with glioblastoma”, Neuro-Oncology, 20(suppl_6):vi191-vi192, 2018.
    DOI: 10.1093/neuonc/noy148.794
  5. Saima Rathore, Hamed Akbari, MacLean P. Nasrallah, Spyridon Bakas, Zev Binder, Martin Rozycki, Sung Min Ha, Elizabeth C. Mamourian, Michel Bilello, Donald M. O’Rourke, Christos Davatzikos, “Quantitative multi-parametric image profiling reveals remarkable heterogeneity within IDH-wildtype glioblastoma, offering prognostic stratification beyond current WHO classifications”, Neuro-Oncology, 20(suppl_6):vi186-vi186, 2018.
    DOI: 10.1093/neuonc/noy148.770
  6. Saima Rathore, Spyridon Bakas, Hamed Akbari, Martin Rozycki, Christos Davatzikos, “Quantitative imaging predictors of overall survival in glioblastoma patients robust in the presence of inter-scanner variations”, Neuro-Oncology, 20(suppl_6):vi184, 2018.
  7. Spyridon Bakas, Gaurav Shukla, Hamed Akbari, Aristeidis Sotiras, Guray Erus, Sung Min Ha, Russell T. Shinohara, Christos Davatzikos, “Prognostic Stratification of GBM Patients via Computational Analysis of Preoperative Structural MRI”, Pendergrass Symposium, University of Pennsylvania, Philadelphia, PA USA, June 2018
    [Magna Cum Laude Award]
  8. Hamed Akbari*, Spyridon Bakas*, Jared M. Pisapia, MacLean Nasrallah, Martin Rozycki, Maria Martinez-Lage, Jennifer Morrissette, Michel Bilello, Nadia Dahmane, Donald M. O'Rourke, Christos Davatzikos, “Non-Invasive In Vivo Determination of EGFRvIII status in Glioblastoma through Analysis of Multi-Parametric MRI”, Pendergrass Symposium, University of Pennsylvania, Philadelphia, PA USA, June 2018
  9. Saima Rathore, Spyridon Bakas, MacLean P. Nasrallah, Stephen J. Bagley, Hamed Akbari, Sung Min Ha, Elizabeth C. Mamourian, Christopher Watt, Christos Davatzikos, “Non-invasive determination of the O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation status in glioblastoma (GBM) using magnetic resonance imaging (MRI)”, Journal of Clinical Oncology, 36(15_suppl):2051-2051, 2018.
    DOI: 10.1200/JCO.2018.36.15_suppl.2051
  10. Hamed Akbari, Spyridon Bakas, Maria Martinez-Lage, MacLean Nasrallah, Martin Rozycki, Saima Rathore, Gaurav Shukla, Suyash Mohan, Michel Bilello, Christos Davatzikos, “Quantitative radiomics and machine learning to distinguish true progression from pseudoprogression in patients with GBM”, 56th Annual Meeting of the American Society of NeuroRadiology (ASNR), 2018.
    [Oral Presentation]
  11. Abdhi Sarkar, Spyridon Bakas, Sung Min Ha, Christos Davatzikos, Russell T. Shinohara, “Intensity Normalization of T1-w Images of Patients with Glioblastomas as a Pre-processing Tool to Improve Subsequent Radiomic Features”, Annual meeting of the Eastern North American Region International Biometric Society, 2018
  12. Spyridon Bakas, Zev A. Binder, Hamed Akbari, MacLean Nasrallah, Jennifer J.D. Morrissette, Sung Min Ha, Donald O'Rourke, Christos Davatzikos, “Unifying magnetic resonance imaging signature of EGFR pathway activation in glioblastoma consistent with uniformly aggressively infiltration”, Annual RadioBiology and Imaging Program Retreat, University of Pennsylvania, Philadelphia, PA USA, 2017.
    [Best Poster Award]
  13. Spyridon Bakas, Gaurav Shukla, Hamed Akbari, Aristeidis Sotiras, Guray Erus, Martin Rozycki, Gregory S. Alexander, Joseph Lombardo, Taki Shinohara, Christos Davatzikos, “Accurate and generalizable pre-operative prognostic stratification of glioblastoma patients using integrative quantitative radiomic analysis of conventional MRI”, Neuro-Oncology 19(suppl6):vi151, 2017, DOI: 10.1093/neuonc/nox168.616
    (Presentation at the 22nd Annual Scientific Meeting of the Society for Neuro-Oncology (SNO), San Francisco, California, November 16 - 19, 2017)
  14. Spyridon Bakas, Zev A. Binder, Jennifer J.D. Morrissette, Hamed Akbari, Donald M. O'Rourke, Christos Davatzikos, “Unifying magnetic resonance imaging signature of EGFR pathway activation in glioblastoma consistent with uniformly aggressively infiltration”, Neuro-Oncology 19(suppl6):vi143, 2017, DOI: 10.1093/neuonc/nox168.586
    (Presentation at the 22nd Annual Scientific Meeting of the Society for Neuro-Oncology (SNO), San Francisco, California, November 16 - 19, 2017)
  15. Spyridon Bakas*, Amy H. Thorne*, Zev A. Binder*, Paul E. Wileyto, Jennifer Morrissette, Hamed Akbari, Saima Rathore, A.Scott, Christos Davatzikos, Donald M. O'Rourke, Frank Furnari, “EGFR extracellular domain point mutant A289V: A therapeutically targetable driver of glioblastoma invasion”, Neuro-Oncology 19(suppl6):vi85, 2017. DOI: 10.1093/neuonc/nox168.348
    (Oral presentation at the 22nd Annual Scientific Meeting of the Society for Neuro-Oncology (SNO), San Francisco, California, November 16 - 19, 2017)
  16. Melanie E. Schweitzer, Mihaela A. Stavarache, Nicholas Petersen, Spyridon Bakas, Apostolos J. Tsiouris, Christos Davatzikos, Michael G. Kaplitt, Mark M. Souweidane, “Modulation of Convection Enhanced Delivery (CED) distribution using Focused Ultrasound (FUS)”, Neuro-Oncology 19(suppl6):vi272, 2017, DOI: 10.1093/neuonc/nox168.1118
    (Oral Presentation in the 22nd Annual Scientific Meeting of the Society for Neuro-Oncology (SNO) and the Society for CNS Interstitial Delivery of Therapeutics (SCIDOT) Joint Conference on Therapeutic Delivery to the CNS, 2017)
  17. Sarthak Pati, Spyridon Bakas, Aristeidis Sotiras, Ratheesh Kalarot, Patmaa Sridharan, Mark Bergman, Saima Rathore, Hamed Akbari, Paul Yushkevich, Taki Shinohara, Yong Fan, Despina Kontos, Ragini Verma, Christos Davatzikos, "Cancer Imaging Phenomics Toolkit (CaPTk): A Radio(geno)mics Software Platform Leveraging Quantitative Imaging Analytics for Computational Oncology", 2017
    (Presentation in the Quantitative Imaging Reading Room Showcase, in the 103rd Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA), Chicago, Illinois, U.S.A., 26 November – 1 December 2017)
  18. Hamed Akbari, Spyridon Bakas, Xiao Da, Donald M. O'Rourke, Christos Davatzikos, "Non-invasive Molecular and Prognostic Stratification of de novo Glioblastoma Patients through Multivariate Radiomic Analysis of Baseline Preoperative Multimodal Magnetic Resonance Imaging", 2017
    (Oral Presentation in 10th World Molecular Imaging Congress (WMIC), Philadelphia, Pennsylvania, U.S.A., 13 – 16 September 2017)
  19. Gaurav Shukla, Spyridon Bakas, Saima Rathore, Hamed Akbari, Aristeidis Sotiras, Christos Davatzikos, "Radiomic Features From Multi-Institutional Glioblastoma MRI Offer Additive Prognostic Value to Clinical and Genomic Markers: Focus on TCGA-GBM Collection", 2017
    (Presentation in the 59st Annual Meeting of the American Society for Radiation Oncology (ASTRO), San Diego, California, U.S.A., 24-27 September 2017)
  20. Jared M.Pisapia, Hamed Akbari, Martin Rozycki, Hannah Goldstein, Spyridon Bakas, Julie S. Moldenhauer, Phillip B. Storm, Deborah M. Zarnow, Richard C.E. Anderson, Gregory G. Heuer, Christos Davatzikos, “Fetal ventriculomegaly: Predicting the need for post-natal cerebrospinal fluid diversion using image analysis and machine learning techniques”. 2017
    (Presentation in the International Symposium on the Fetal Brain, Washington, D.C., August 2017)
  21. Spyridon Bakas, Zev A. Binder, Hamed Akbari, Maria Martinez-Lage, Martin Rozycki, Jennifer J.D. Morrissette, Nadia Dahmane, Donald M. O'Rourke, Christos Davatzikos, "Highly-expressed wild-type EGFR and EGFRvIII mutant glioblastomas have similar MRI signature, consistent with deep peritumoral infiltration", Neuro-Oncology, 18(Suppl.6):VI125-VI126, 2016, DOI: 10.1093/neuonc/now212.523
    (Oral Presentation in the 21st Annual Scientific Meeting of the Society for Neuro-Oncology (SNO), Scottsdale, Arizona, U.S.A., 17-20 November 2016)
  22. Zev A. Binder, Spyridon Bakas, E. Paul Wileyto, Hamed Akbari, Saima Rathore, Martin Rozycki, Jennifer J.D. Morrissette, Maria Martinez-Lage, Nadia Dahmane, Christos Davatzikos, Donald M. O'Rourke, "Extracellular EGFR289 activating mutations confer poorer survival and exhibit radiographic signature of enhanced motility in primary glioblastoma", Neuro-Oncology, 18(Suppl.6):VI105-VI106, 2016, DOI: 10.1093/neuonc/now212.441
    (Presented in the 21st Annual Scientific Meeting of the Society for Neuro-Oncology (SNO), Scottsdale, Arizona, U.S.A., 17-20 November 2016)
  23. Saima Rathore, Hamed Akbari, Martin Rozycki, Spyridon Bakas, Christos Davatzikos, "Imaging pattern analysis reveals three distinct phenotypic subtypes of GBM with different survival rates", Neuro-Oncology, 18(Suppl.6):VI128, 2016, DOI: 10.1093/neuonc/now212.532
    (Presented in the 21st Annual Scientific Meeting of the Society for Neuro-Oncology (SNO), Scottsdale, Arizona, U.S.A., 17-20 November 2016)
  24. Jared M. Pisapia, Martin Rozycki, Hamed Akbari, Hannah E. Goldstein, Spyridon Bakas, Julie S. Moldenhauer, Phillip B. Storm, Deborah M. Zarnow, Richard C. E. Anderson, Gregory G. Heuer, Christos Davatzikos, "Fetal Ventriculomegaly: External validity of a fetal MRI-based model to predict the need for post-natal CSF diversion", 2016.
    (Oral Presentation in the 44th Annual Meeting of the International Society for Pediatric Neurosurgery, Kobe, Japan)
  25. Jared M. Pisapia, Hamed Akbari, Spyridon Bakas, Martin Rozycki, Julie S. Moldenhauer, Phillip B. Storm, Deborah M. Zarnow, Gregory G. Heuer, Christos Davatzikos, "Fetal Ventriculomegaly: Predicting Need for Post-Natal Shunt using Machine Learning and Fetal MRI", 2015.
    (Oral Presentation in the 44th Annual Meeting of the AANS/CNS Section on Pediatric Neurological Surgery, Seattle, Washington, U.S.A., 8-11 December 2015)
  26. Jared M. Pisapia, Hamed Akbari, Spyridon Bakas, Martin Rozycki, Julie S. Moldenhauer, Jayesh P. Thawani, Phillip B. Storm, Deborah M. Zarnow, Christos Davatzikos, Gregory G. Heuer. "Fetal Ventriculomegaly: Ventricle Size Correlates Better with Atrial Diameter than with Fronto-Occipital Horn Ratio", 2015.
    (Presented in the 44th Annual Meeting of the AANS/CNS Section on Pediatric Neurological Surgery, Seattle, Washington, U.S.A., 8-11 December 2015)
  27. Hamed Akbari, Spyridon Bakas, Martin Rozycki, Xiao Da, Jared Pisapia, Michel Bilello, Donald M. O'Rourke, Christos Davatzikos "Non-Invasive Determination of Epidermal Growth Factor Receptor Variant III Expression in Glioblastoma through Analysis of Multi-Parametric Magnetic Resonance Imaging", 2015
    (Oral Presentation in 101st Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA), Chicago, Illinois, U.S.A., 29 November – 4 December 2015)
  28. Spyridon Bakas, Hamed Akbari, Jared Pisapia, Martin Rozycki, Donald M. O'Rourke, Christos Davatzikos, "Identification of Imaging Signatures of the Epidermal Growth Factor Receptor Variant III (EGFRvIII) in Glioblastoma", Neuro-Oncology, 17(Suppl.5):V154, 2015, DOI: 10.1093/neuonc/nov225.05
    (Oral Presentation in the 20th Annual Scientific Meeting of the Society for Neuro-Oncology (SNO), San Antonio, Texas, U.S.A., 19-22 November 2015)
  29. Spyridon Bakas, Christos Davatzikos, "Predictive Modeling in Brain Cancer Using Machine Learning, Imaging and Genomics: Using Informatics to Obtain Rich Characterizations of Aggressive Brain Tumors, in Support of Precision Medicine", Invited talk in MICCAI NIH Workshop on Computational Precision Medicine II, 2015.
    (Presented in the Technische Universität München (T.U.M.), Munich, Germany, 5-9 Oct 2015)
  30. Spyridon Bakas, Bilwaj Gaonkar, Christos Davatzikos, "Improved Prediction of Post-surgical Survival in Glioblastoma Through Integrative Genomic and Epigenomic Analysis", The Cancer Genome Atlas' 4th Annual Scientific Symposium, 2015. DOI: 10.13140/RG.2.1.1156.1841
    (Presented in the National Institutes of Health (NIH) Campus, Bethesda, MD, U.S.A., 11-12 May 2015)

  1. Spyridon Bakas, Hamed Akbari, Aristeidis Sotiras, Michel Bilello, Martin Rozycki, Justin Kirby, John Freymann, Keyvan Farahani, Christos Davatzikos. "Segmentation Labels and Radiomic Features for the Pre-operative Scans of the TCGA-GBM collection", The Cancer Imaging Archive, 2017.    DOI: 10.7937/K9/TCIA.2017.KLXWJJ1Q
  2. Spyridon Bakas, Hamed Akbari, Aristeidis Sotiras, Michel Bilello, Martin Rozycki, Justin Kirby, John Freymann, Keyvan Farahani, Christos Davatzikos. "Segmentation Labels and Radiomic Features for the Pre-operative Scans of the TCGA-LGG collection", The Cancer Imaging Archive, 2017.    DOI: 10.7937/K9/TCIA.2017.GJQ7R0EF

  • "Computer-Aided Localisation, Segmentation and Quantification of Focal Liver Lesions in Contrast-Enhanced Ultrasound", Kingston University - Faculty of Science, Engineering & Computing (SEC) - Digital Imaging Research Centre (DIRC) - BioImaging Group (BIG)
    (Ph.D. Thesis - 2014)
  • "Discriminative vs. Generative Methods for Face Detection", University College London (UCL) - Department of Computer Science (CS) - Vision, Imaging & Virtual Environments
    (M.Sc. Thesis - 2007)
  • "Three-Dimensional Reconstruction from Two-Dimensional Representations", Kingston University - Faculty of Technology - School of Computing and Information Systems
    (B.Sc. Dissertation - 2005)

  • Peritumoral Heterogeneity Index (PHI) Estimator is a lightweight tool, built towards the following goals:
    - Perform quantitative pattern analysis of the spatial heterogeneity of peritumoral perfusion imaging dynamics, retrieved from Dynamic Susceptibility Contrast Magnetic Resonance Imaging (DSC-MRI) data.
    - Evaluate the imaging biomarker of the Epidermal Growth Factor Receptor variant III (EGFRvIII) mutation status, in individual patients diagnosed with glioblastoma.
  • Cancer and Phenomics Toolkit (CapTk) showcases some of the highlight applications from the Center for Biomedical Image Computing and Analytics (CBICA) along with advanced visualization and interactive capabilities to make it a complete radiological tool. It also provides the initialization front-end for:
    - GLISTRboost (The best performing method during BRATS 2015 challenge)
    - GLioma Image SegmenTation and Registration (GLISTR)
    - Pre-Operative and post-Recurrence brain Tumor Registration (PORTR)
    and entails the functionality of:
    - Evaluating the status of the EGFRvIII mutant in pre-operative scans of patients with brain tumors
    - Producing parametric probability maps of infiltration/recurrence of brain glioblastoma
    - Performing a segmentation of brain tumors using deep learning
  • GLISTRboost: Boosted GLioma Image SegmenTation and Registration describes a hybrid generative-discriminative method for segmenting low- and high-grade gliomas in multimodal MRI volumes. Note that this is the winning method of the Multimodal Brain Tumor Image Segmentation (BRATS) Challenge, held in conjunction with the Medical Image Computing and Computer Assisted Intervention (MICCAI) conference in Technische Universitaet Muenchen (TUM) in Munich (Germany) - October 2015
  • GLioma Image SegmenTation and Registration (GLISTR) is a software package designed for jointly segmenting multimodal MRI brain scans of glioma patients and registering these scans to a normal, healthy atlas under an Expectation-Maximisation framework.
  • Brain Tumor Viewer (BTV) is a lightweight viewer, built for fast and simple interaction with MRI image volumes. BTV is primarily designed for visualizing multimodal MRI brain volumes and initializing seed-points for the following software packages:
    - GLioma Image SegmenTation and Registration (GLISTR)
    - Pre-Operative and post-Recurrence brain Tumor Registration (PORTR)
    After initializing these seed-points, a user can generate execution scripts through BTV's graphical user interface for various platforms and custom input parameters.

Funding

Active Funding
  • Principal Investigator
    • The Federated Tumor Segmentation (FeTS) platform: An intuitive tool facilitating secure multi-institutional collaboration (U01CA242871, NIH/NCI/ITCR, PI: Bakas, Spyridon, 07/01/2019 - 06/30/2022)
  • Collaborative Funding
    • Imaging Signatures of Genetic Mutations in Glioblastoma Using Machine Learning (R01NS042645, NIH/NINDS, PI: Davatzikos, Christos (Role: Co-I), 12/15/2019 - 11/30/2024)

    • Generalizable quantitative imaging and machine learning signatures in glioblastoma, for precision diagnostics and personalized treatment: the ReSPOND consortium (R01CA269948, NIH/NCI, PI: Davatzikos, Christos (Role: Co-I), 06/15/2022 - 05/15/2027)

Completed
  • Populating the Penn Immune Health Report to Support Precision Medicine: Immunohistochemical Markers to Predict Response to Checkpoint Blockade in Non-Small Cell Lung Cancer (NSCLC) (Abramson Cancer Center, PI: Thompson, Jeffrey (Role: Co-I), 04/22/2020 - 04/21/2021)
  • A pilot radiogenomics study evaluating MRI signatures of therapeutically targetable gene expression alterations in human glioblastoma (CTSA/ITMAT/TBIC, PIs: Bakas, Spyridon / Bagley, Stephen, 03/01/2019 - 02/28/2021)
  • Democratization of AI-based Lesion Segmentation (Intramural CBICA seed grant, PI: Bakas, Spyridon, 02/03/2020 - 02/02/2021)
  • Cancer imaging phenomics software suite: application to brain and breast cancer (1U24CA189523, NIH/NCI/ITCR, PI: Davatzikos, Christos, 09/01/2015 - 08/31/2020)
  • Predicting brain tumor progression via multiparametric image analysis and modeling (R01NS042645, NIH/NINDS, PI: Davatzikos, Christos, 09/01/2014 - 05/31/2020)
  • Refined Personalized Radiotherapy Target Volume Definition using Predictive Recurrence maps in Glioblastoma (Intramural CBICA seed grant, PI: Bakas, Spyridon, 06/01/2018 - 05/31/2019)
  • In vivo surrogate markers of clinically-relevant molecular characteristics of glioblastoma, based on multivariate machine learning and clinically-acquired MRI (CTSA/ITMAT/TBIC, PIs: Bakas, Spyridon / Davatzikos, Christos, 02/01/2017 - 01/31/2019)
  • In vivo predictive models of meningioma progression, (CTSA/ITMAT/TBIC, PIs: Dahmane, Nadia / Grady, Sean / Davatzikos, Christos, 02/01/2017 - 01/31/2019)

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