Center for Magnetic Resonance & Optical Imaging

Hari Hariharan, Ph.D.

Associate Director (Tech Transfer), CMROI

Senior Research Investigator, Radiology

Contact Information

Tel:215-898-9357
Fax: 215-573-2113
Email: harih@pennmedicine.upenn.edu

Education

B.Sc. Chemistry, Madurai University, India

M.Sc. Chemistry, Indian Institute of Technology-Kanpur, Kanpur, India

Ph.D. Chemistry, Indian Institute of Technology-Kanpur, Kanpur, India

Recent Work

Research Interests

• MRI and MRS Applications
• CEST Imaging
• MRS Post Processing SW development
• Pulse Sequence Development

Professional Experience

Certifications

CITI Protection of Human Subjects Training

VPR

HIPPA Privacy Training

Selected Publications

• Krishnamoorthy G, Nanga RPR, Bagga P, Hariharan H, Reddy R. High quality three-dimensional gagCEST imaging of in vivo human knee cartilage at 7 Tesla. Magn Reson Med. 2017 May;77(5):1866-1873. doi: 10.1002/mrm.26265. Epub 2016 May 13. PubMed PMID: 27174078; PMCID: PMC5107363.
• Cai K, Tain RW, Zhou XJ, Damen FC, Scotti AM, Hariharan H, Poptani H, Reddy R. Creatine CEST MRI for Differentiating Gliomas with Different Degrees of Aggressiveness. Mol Imaging Biol. 2017 Apr;19(2):225-232. doi: 10.1007/s11307-016-0995-0. PubMed PMID: 27541025.
• Crescenzi R, DeBrosse C, Nanga RP, Byrne MD, Krishnamoorthy G, D'Aquilla K, Nath H, Morales KH, Iba M, Hariharan H, Lee VM, Detre JA, Reddy R. Longitudinal imaging reveals subhippocampal dynamics in glutamate levels associated with histopathologic events in a mouse model of tauopathy and healthy mice. Hippocampus. 2017 Mar;27(3):285-302. doi: 10.1002/hipo.22693. Epub 2017 Feb 3. PubMed PMID: 27997993; PMCID: PMC5396955.
• Roalf DR, Nanga RP, Rupert PE, Hariharan H, Quarmley M, Calkins ME, Dress E, Prabhakaran K, Elliott MA, Moberg PJ, Gur RC, Gur RE, Reddy R, Turetsky BI. Glutamate imaging (GluCEST) reveals lower brain GluCEST contrast in patients on the psychosis spectrum. Mol Psychiatry. 2017 Jan 24. doi: 10.1038/mp.2016.258. [Epub ahead of print] PubMed PMID: 28115738.
• Kogan F, Stafford RB, Englund EK, Gold GE, Hariharan H, Detre JA, Reddy R.Perfusion has no effect on the in vivo CEST effect from Cr (CrCEST) in skeletal muscle. NMR Biomed. 2017 Jan; 30(1). doi: 10.1002/nbm.3673. [Epub 2016 Nov 29] PMCID:PMC5518925.
• Shanmugan S, Loughead J, Nanga RP, Elliott M, Hariharan H, Appleby D, Kim D, Ruparel K, Reddy R, Brown TE, Epperson CN. Lisdexamfetamine Effects on Executive Activation and Neurochemistry in Menopausal Women with Executive Function Difficulties.  Neuropsychopharmacology. 2017 Jan;42(2):437-445. doi: 10.1038/npp.2016.162. [Epub 2016 Aug 23] PMCID:PMC5399233.
• DeBrosse C, Nanga RP, Wilson N, D'Aquilla K, Elliott M, Hariharan H, Yan F, Wade K, Nguyen S, Worsley D, Parris-Skeete C, McCormick E, Xiao R, Cunningham ZZ, Fishbein L, Nathanson KL, Lynch DR, Stallings VA, Yudkoff M, Falk MJ, Reddy R, McCormack SE. Muscle oxidative phosphorylation quantitation using creatine chemical exchange saturation transfer (CrCEST) MRI in mitochondrial disorders. JCI Insight. 2016 Nov 3;1(18):e88207. PMCID:PMC5085612.
• Nanga RP, Hariharan H, Reddy R., Fully automated macromolecule suppressed single voxel glutamate spectroscopy (FAMOUS SVGS). J Transl Med. 2016 Jul 26;14(1):220. doi: 10.1186/s12967-016-0970-1. PMCID:PMC4960747.
• Bagga P, Crescenzi R, Krishnamoorthy G, Verma G, Nanga RP, Reddy D, Greenberg J, Detre JA, Hariharan H, Reddy R. Mapping the alterations in glutamate with GluCEST MRI in a mouse model of dopamine deficiency. J Neurochem. 2016 Nov;139(3):432-439. doi: 10.1111/jnc.13771. PMCID: PMC5077646.
• Wilson NE, D’Aquilla K, Debrosse C, Hariharan H, Reddy R. Localized, gradient reversed ultrafast z-spectroscopy in vivo at 7T . Magn. Reson. Med. 2016 July 1. doi: 10.1002/mrm.26314. [Epub ahead of print]. PMCID: PMC5023501.
• Krishnamoorthy G, Nanga RP, Bagga P, Hariharan H, Reddy R. High Quality three-dimensional gagCEST imaging of in vivo human knee cartilage at 7T. Magn. Reson. Med. 2016 May 13. doi: 10.1002/mrm.26265. [Epub ahead of print]. PMCID: PMC5107363.
• Haris M, Singh A, Reddy S, Bagga P, Kneeland JB, Tjoumakaris FP, Hariharan H, Marincola FM,  Reddy R. Characterization of viscosupplementation formulations using chemical exchange saturation transfer (ViscoCEST). J. Transl. Med. 2016 April 12. doi: 10.1186/s12967-016-0850-8. PMCID: PMC4830049.
• DeBrosse C, Nanga RP, Bagga P, Nath K, Haris M, Marincola F, Schnall MD, Hariharan H, Reddy R. Lactate Chemical Exchange Saturation Transfer (LATEST) Imaging in vivo A Biomarker for LDH Activity. Sci Rep. 2016 Jan 22;6:19517. doi: 10.1038/srep19517. PMCID: PMC4726389.
• Davis KA, Nanga RPR, Das S, Chen SH, Hadar PN, Pollard JR, Lucas TH, Shinohara RT, Litt B, Hariharan H, Elliott MA, Detre JA, Reddy R.  Glutamate Imaging (GluCEST) Lateralizes Epileptic Foci in Non-Lesional Temporal Lobe Epilepsy, Sci Transl Med. 2015 Oct 14;7(309):309ra161. doi: 10.1126/scitranslmed.aaa7095. PMCID: PMC4710355.
• Haris M, Yadav SK, Rizwan A, Singh A, Wang E, Hariharan H, Reddy R, Marincola FM.  Molecular Magnetic Resonance Imaging in Cancer.  J Transl Med. 2015 Sep 23;13(1):313. doi: 10.1186/s12967-015-0659-x.  PMCID: PMC4579835.
• Singh A, Reddy D, Haris M, Cai K, Rajender Reddy K, Hariharan H, Reddy R. T1ρ MRI of healthy and fibrotic human livers at 1.5 T. J Transl Med. 2015 Sep 8;13:292. doi: 10.1186/s12967-015-0648-0. PMCID: PMC4562204.
• Cai K, Singh A, Poptani H, Li W, Yang S, Lu Y, Hariharan H, Zhou XJ, Reddy R. CEST signal at 2ppm (CEST@2ppm) from Z-spectral fitting correlates with creatine distribution in brain tumor. NMR Biomed. 2015 Jan;28(1):1-8. doi: 10.1002/nbm.3216. Epub 2014 Oct 8. PMCID: PMC4257884.
• Crescenzi R, DeBrosse C, Nanga RP, Reddy S, Haris M, Hariharan H, Iba M, Lee VM, Detre JA, Borthakur A, Reddy R. In vivo measurement of glutamate loss is associated with synapse loss in a mouse model of tauopathy. Neuroimage. 2014 Nov 1;101:185-92. doi: 10.1016/j.neuroimage.2014.06.067. Epub 2014 Jul 5. PMCID: PMC4303593.
• Kogan F, Haris M, Debrosse C, Singh A, Nanga RP, Cai K, Hariharan H, Reddy R. In vivo chemical exchange saturation transfer imaging of creatine (CrCEST) in skeletal muscle at 3T. J Magn Reson Imaging. 2014 Sep;40(3):596-602. doi: 10.1002/jmri.24412. Epub 2013 Oct 31. PMCID: PMC4059780.
• Haris M, Singh A, Mohammed I, Ittyerah R, Nath K, Nanga RP, Debrosse C, Kogan F, Cai K, Poptani H, Reddy D, Hariharan H, Reddy R. In vivo magnetic resonance imaging of tumor protease activity. Sci Rep. 2014 Aug 15;4:6081. PMCID: PMC4133714.
• Haris M, Singh A, Cai K, Nath K, Verma G, Nanga RP, Hariharan H, Detre JA, Epperson N, Reddy R. High resolution mapping of modafinil induced changes in glutamate level in rat brain. PLoS One. 2014 Jul 28;9(7):e103154. doi: 10.1371/journal.pone.0103154. eCollection 2014. PMCID: PMC4113382.
• Nanga RP, DeBrosse C, Singh A, D'Aquilla K, Hariharan H, Reddy R. Glutaminase catalyzes reaction of glutamate to GABA. Biochem Biophys Res Commun. 2014 Jun 13;448(4):361-4. doi: 10.1016/j.bbrc.2014.04.059. Epub 2014 Apr 19. PMCID: PMC4097173.
• Singh A, Haris M, Cai K, Kogan F, Hariharan H, Reddy R. High Resolution T1ρ Mapping of In Vivo Human Knee Cartilage at 7T. PLOS ONE, May 2014, 9(5): e97486.  PMCID: PMC4022681.
• Haris M, Singh A, Cai K, Kogan F,  McGarvey J, DeBrosse C, Zsido GA, Walter RT Witschey WRT, Koomalsingh K, Pilla JJ, Chirinos JA, Ferrari VA, Gorman JH, Hariharan H, Robert Gorman RC, Reddy R.  A Technique for In Vivo Mapping of Myocardial Creatine Kinase Metabolism, Nat Med. 2014 Feb;20(2):209-14. doi: 10.1038/nm.3436. Epub 2014 Jan 12. PMCID: PMC4127628.
• Cai K, Singh A, Rolf D, Nanga RP, Haris M, Hariharan H, Gur R, Reddy R. Mapping glutamate in subcortical brain structures using high-resolution GluCEST MRI. NMR in Biomed. 2013 Oct;26(10):1278-84. PMCID: PMC3999922.
• Kogan F, Singh A, Debrosse C, Haris M, Cai K, Nanga RP, Elliott M, Hariharan H, and Reddy R. Imaging of glutamate in the spinal cord using GluCEST. NeuroImage 2013 Aug 15;(77): 262-7.  PMCID: PMC3804007.
• Kogan F, Hariharan H, Reddy R. Chemical Exchange Saturation Transfer (CEST) Imaging: Description of Technique and Potential Clinical Applications. Curr Radiol Rep. 2013 Jun 1;1(2):102-114. PMCID: PMC3665411.
• Haris M, Nath K, Cai K, Singh A, Crescenzi R, Kogan F, Verma G, Reddy S, Hariharan H, Melhem ER, Reddy R. Imaging of glutamate neurotransmitter alterations in Alzheimer's disease. NMR Biomed. 2013 Apr;26(4):386-91. doi: 10.1002/nbm.2875. Epub 2012 Oct 9. PMCID: PMC3556355.
• Singh A, Cai K, Haris M, Hariharan H, Reddy R. On B1 inhomogeneity correction of in vivo human brain glutamate chemical exchange saturation transfer contrast at 7T. Magn Reson Med. 2013 Mar 1;69(3):818-24. doi: 10.1002/mrm.24290. Epub 2012 Apr 17. PMCID: PMC4031461.
• Kogan F, Haris M, Singh A, Cai K, DeBrosse C, Nanga RPR, Hariharan H, Reddy R.  Method for High-Resolution Imaging of Creatine In vivo Using Chemical Exchange Saturation Transfer, Magn. Reson. Med. (2014) Jan;71(1):164-172, PMCID: PMC3725192.

T2 quantitation of articular cartilage at 1.5 T. Maier CF, Tan SG, Hariharan H, Potter HG.  J Magn Reson Imaging. 2003 Mar;17(3):358-64.