Mini Theta Burst TMS to Promote Brain Plasticity Indexed by fMRI (NARSAD)

Non-invasive transcranial magnetic stimulation (TMS) is now FDA-approved for the treatment of major depressive disorder (MDD). However, there is growing evidence that the targeting strategy for  delivering TMS treatment would yield superior clinical outcomes if it were more tailored to individual neuroanatomy and functional connectivity. In this study, we plan to examine whether functional MRI-guided TMS might be more effective than traditional methods at influencing neural circuit communication. If this is true, future studies may utilize these methods to yield an even greater leap forward in promoting optimal clinical outcomes using TMS for treatment.