Second Call for Proposals focused on COVID-19-related Cardiovascular Disease The Cardiovascular Translational Dream Team Initiative


Opening date: May 13, 2021
Application due date: July 14, 2021 at 5pm ET
Anticipated funding start date: September 1, 2021


Rationale and Overview

We are witnessing an unprecedented pandemic. In addition to the significant mortality related to acute SARS-CoV-2 (COVID) infection, chronic complications, including heart and vascular sequelae, are now recognized to cause significant morbidity. However, the frequency and relevance of post-COVID cardiovascular (CV) complications have not been well-defined, and strategies for detection and risk stratification do not exist. In addition, the contribution of CV derangements to the so-called COVID “long hauler” syndrome is unknown. The Penn Cardiovascular Institute (CVI) recently launched an initiative to provide seed funding for team-based efforts focused on COVID-related myocarditis.  We are now making a second call for proposals with broadened target areas including both heart and vascular disease (e.g. vasculopathy, coagulopathy), and emphasis on short- and long-term complications post-infection. Studies focused on existing human cohorts and/or biobank samples will be prioritized. Applications will be reviewed and selected by an Executive Steering Committee (ESC) comprised of senior Penn scientists and ad-hoc experts.  We plan to fund up to 2-3 projects ($50,000- $100,000 each) for a one-year period. It is our hope that this seed funding will allow rapid acquisition of early-stage data to provide rationale for longer-term projects ultimately funded through external sources such as NIH, foundations, and/or industry. Notably, the NIH has also announced, and is launching, several efforts to fund chronic complications of COVID-19.


Examples of projects that would be appropriate for this funding mechanism include but are not limited to:

Please direct any questions related to the application or funding to Teresa Leone at


Instructions and Templates: