Recent CVI Research

Xiaolong Zhu, Ioana Soaita, Zoltan Arany, and Michael Simons

Acetate controls endothelial-to-mesenchymal transition

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Daniel Baker, Zoltan Arany, Joseph Baur, Jonathan Epstein, and Carl June

CAR T therapy beyond cancer: the evolution of a living drug

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Sharlene Day, Marcus Wagner, and Andrea Thompson

An Unbiased Screen Identified the Hsp70-BAG3 Complex as a Regulator of Myosin-Binding Protein C3

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Kiran Musunuru, Dominique Brooks, Mohamad-Gabriel Alameh, and Xiao Wang

Rapid and definitive treatment of phenylketonuria in variant-humanized mice with corrective editing

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Megan Blair and Zoltan Arany

Branched-chain amino acid catabolism in muscle affects systemic BCAA levels but not insulin resistance

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Elvin Leonard and Arndt Siekmann

Temporally and regionally distinct morphogenetic processes govern zebrafish caudal fin blood vessel network expansion

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Timothy Matsuura, Daniel Kelly

Ketones and the Heart: Metabolic Principles and Therapeutic Implications

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Tsunehisa Yamamoto, Daniel Kelly, Mitchell Lazar

RIP140 Deficiency Enhances Cardiac Fuel Metabolism and Protects Mice from Heart Failure

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Amy Lisanti

Developmental Care for Hospitalized Infants With Complex Congenital Heart Disease: A Science Advisory From the American Heart Association

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Jennifer Lewey

Challenges and opportunities to improving research in maternal cardiovascular health

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Parisha Shah and Rajan Jain

An atlas of lamina-associated chromatin across twelve human cell types reveals an intermediate chromatin subtype

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Estibaliz Castillero, Giovanni Ferrari, and Robert Levy

Decreased serotonin transporter activity in the mitral valve contributes to progression of degenerative mitral regurgitation

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David Frank, Prashant Chandrasekaran, and Nicholas Negretti

CXCL12 defines lung endothelial heterogeneity and promotes distal vascular growth

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Emily Flam, Kenneth Margulies, and Zoltan Arany

Integrated landscape of cardiac metabolism in end-stage human nonischemic dilated cardiomyopathy

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Senthil Selvaraj and Kenneth Margulies

Metabolomic Profiling of the Effects of Dapagliflozin in Heart Failure with Reduced Ejection Fraction: DEFINE-HF

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Kristina Li, Shogo Waga, Bridget Gosis, and Zoltan Arany

Folliculin promotes substrate-selective mTORC1 activity by activating RagC to recruit TFE3

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Yanqing Anna Gong and Yi Fan

Endothelial plasticity drives aberrant vascularization and impedes cardiac repair after myocardial infarction

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Eliot Peyster and Kenneth Margulies

Computational Analysis of Routine Biopsies Improves Diagnosis and Prediction of Cardiac Allograft Vasculopathy

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Bridget Gosis and Zoltan Arany

Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of mTORC1

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Roman Tsaryk and Arndt Siekmann

Shear stress switches the association of endothelial enhancers from ETV/ETS to KLF transcription factor binding sites

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Sharlene Day and Michael Ostap

Myosin modulators: emerging approaches for the treatment of cardiomyopathies and heart failure

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Elvin V. Leonard, Arndt Siekmann

Regenerating vascular mural cells in zebrafish fin blood vessels are not derived from pre-existing mural cells and differentially require Pdgfrb signalling for their development

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Daniel Rader

A genome-first approach to rare variants in hypertrophic cardiomyopathy genes MYBPC3 and MYH7 in a medical biobank

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Daniel Rader

Sortilin restricts secretion of apolipoprotein B-100 by hepatocytes under stressed but not basal conditions

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Ayon Ibrahim, Michael Neinast, and Kristina Li

Insulin-stimulated adipocytes secrete lactate to promote endothelial fatty acid uptake and transport

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Joel Rurik, Jonathan Epstein, and Hamideh Parhiz

CAR T cells produced in vivo to treat cardiac injury

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Zoltan Arany, Benjamin Prosser, and Quentin McAfee

Truncated titin proteins in dilated cardiomyopathy

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Sharlene Day and Anjali Owens

Valsartan in early-stage hypertrophic cardiomyopathy: a randomized phase 2 trial

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Wonho Kim, Ricardo Linares-Saldana, Nikhita Bolar, and Rajan Jain

BRD4 orchestrates genome folding to promote neural crest differentiation

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Zoltan Arany

Laminar Flow on Endothelial Cells Suppresses eNOS O-GlcNAcylation to Promote eNOS Activity

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Steven Keller and Mark Kahn

Genetic blockade of lymphangiogenesis does not impair cardiac function after myocardial infarction

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Zoltan Arany

Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion

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Daniel Rader

Associations of HDL metrics with coronary artery calcium score and density among women traversing menopause

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Rajat Deo

COVID-19 and Cardiac Arrhythmias

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Kiran Musunuru

In vivo CRISPR base editing of PCSK9 durability lowers cholesterol in primates

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Senthil Selvaraj

Atrial Fibrillation and Ischemic Stroke with the Amyloidogenic V122I Transthyretin Variant among Black Americans

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Rahul Goli & Zoltan Arany

Genetic and Phenotypic Landscape of Peripartum Cardiomyopathy

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Aileen Ren & Mark Kahn

PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism

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Jarod Zepp & Edward Morrisey

Genomic, epigenomic, and biophysical cues controlling the emergence of the lung alveolus

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Parisha Shah, Wenjian Lv, Kiran Musunuru, & Rajan Jain

Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes

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Rohan Palanki & Michael Mitchell

Delivery technologies for in utero gene therapy

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John Greenwood & Benjamin Abella

Low Microcirculatory Perfused Vessel Density and High Heterogeneity are Associated with Increased Intensity and Duration of Lactic Acidosis After Cardiac Surgery with Cardiopulmonary Bypass

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Sharlene Day

2020 AHA/ACC Guideline for the Diagnosis and Treatment of Patients with Hypertrophic Cardiomyopathy

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Jordana Cohen & Julio Chirinos

Continuation versus discontinuation of renin-angiotensin system inhibitors in patients admitted to hospital with COVID-19: a prospective, randomized, open-label, blinded endpoint trial

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Timothy Matsuura & Daniel Kelly

Ketone Ester Treatment Improves Cardiac Function and Reduces Pathologic Remodeling in Preclinical Models of Heart Failure