Our laboratory has two areas of interest – prostanoid biology and molecular clocks.
In the case of prostanoids we are interested to parse and exploit contributors to interindividual differences in NSAID response so that we can utilize AI and machine learning approaches to develop paradigms predictive of efficacy and risk. We are also interested in elucidating the therapeutic opportunity of novel drug targets in the eicosanoid pathway. In the case of clocks, we are interested in how a decline in oscillatory function may contribute to age related phenotypes. We also wish to integrate multiple remote sensing approaches with multi-omics analyses to characterize the human chronobiome. This may afford the opportunity to obtain, in an unbiased fashion, mechanistic insights into time dependent disease phenotypes, such as non-dipping hypertension.
Perhaps the distinguishing feature of our group is that we pursue interdisciplinary translational science with a focus on therapeutics. Thus, we work in different model systems – mammalian cells, fish and mice – but also in humans. Ideally, we develop quantitative approaches that can be projected from our experiments in the model systems to guide elucidation of drug action in humans. To this end, we have long utilized mass spectrometry, initially to target the arachidonate derived lipidome, but latterly the metabolome and the proteome. We have a strong collaboration with Rick Bushman focused on the microbiome. These approaches generate lots of data and we have for many years integrated directly in the group statisticians and bioinformaticians.
More than 120 postdoctoral trainees have passed through this laboratory in the almost 40 years of its existence. Roughly half are M.D.s or M.D. – Ph.D.s and of the former group roughly half have never been in a laboratory before. Graduates of the program have moved on to faculty and administrative roles in academia, scientific appointments in pharma and biotech, jobs in funding bodies and the financial sector. The laboratory is heavily biased towards postdocs but there are usually 2 or 3 graduate students in the group as well.
If you want a training experience that blends the rigor of basic science with the relevance to human health of clinical research, this is the place for you!