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Axonal de- and regeneration

Following injury axons of the peripheral nervous system have the remarkable ability to regenerate reconnect with their original targets. Surprisingly, the number of regenerating axons- even using best surgical practices- is estimated to be lower than 30%, thereby siginifcantly reducing functional regneration. Yet despite its clinical relevance the molecular program and the cellular mechanisms that enable regenerating axons to navigate across the lesion site towards their original synaptic targets, are not well understood. Using transgenic expression of fluorescently tagged proteins in combination with genetic mutants, we are now investigating the cellular interaction between injured axons and neighboring glial cells to decipher the molecular-genetic program underlying peripheral nerve regeneration.

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Isaacman-Beck, J., Schneider, V., Franzini-Armstrong, C, Granato, M. 2015: The lh3 glycosyltransferase directs target selective peripheral nerve regeneration. Neuron 88, 1-13. pdf.

Rosenberg, A., Isaacman-Beck, J, Franzini-Armstrong, C, Granato, M. 2014: Schwann cells and DCC direct regenerating motor axons towards their original path. J. Neuroscience (44) 14668-81. pdf This work is featured in 'This week in the Journal'. Movies for Rosenberg et al.: Movie 1, Movie 2, Movie 3, Movie 4.

Rosenberg, A., Wolman, M, Franzini-Armstrong, C, Granato, M. In vivo macrophage-nerve interactions following peripheral nerve injury. 2012. J. Neuroscience (32), 4440-56. pdf and comment